MX375204B - Formulación de factor de crecimiento de fibroblastos 18 en geles de xiloglucano. - Google Patents
Formulación de factor de crecimiento de fibroblastos 18 en geles de xiloglucano.Info
- Publication number
- MX375204B MX375204B MX2016008441A MX2016008441A MX375204B MX 375204 B MX375204 B MX 375204B MX 2016008441 A MX2016008441 A MX 2016008441A MX 2016008441 A MX2016008441 A MX 2016008441A MX 375204 B MX375204 B MX 375204B
- Authority
- MX
- Mexico
- Prior art keywords
- growth factor
- fibroblast growth
- formulation
- xyloglucan
- hydrogels
- Prior art date
Links
- 102000003977 fibroblast growth factor 18 Human genes 0.000 title abstract 3
- 108090000370 fibroblast growth factor 18 Proteins 0.000 title abstract 3
- 229920002000 Xyloglucan Polymers 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 239000000499 gel Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000000017 hydrogel Substances 0.000 abstract 3
- 206010007710 Cartilage injury Diseases 0.000 abstract 1
- 208000015100 cartilage disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
Abstract
La invención se refiere al campo de las formulaciones farmacéuticas; más en particular, está dirigida a hidrogeles de xiloglucano que comprenden un compuesto de factor de crecimiento de fibroblastos 18 (FGF-18) y a métodos para producción de dicho hidrogeles; los hidrogeles de la invención se pueden usar, una vez formados in situ, para el tratamiento de trastornos de cartílago tales como osteoartritis o lesión de cartílago.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13199588 | 2013-12-24 | ||
| PCT/EP2014/079194 WO2015097233A1 (en) | 2013-12-24 | 2014-12-23 | Fgf-18 formulation in xyloglucan gels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016008441A MX2016008441A (es) | 2017-01-11 |
| MX375204B true MX375204B (es) | 2025-03-06 |
Family
ID=49882941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016008441A MX375204B (es) | 2013-12-24 | 2014-12-23 | Formulación de factor de crecimiento de fibroblastos 18 en geles de xiloglucano. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10293051B2 (es) |
| EP (1) | EP3086803B1 (es) |
| JP (1) | JP6791754B2 (es) |
| KR (2) | KR102622290B1 (es) |
| CN (1) | CN106029085B (es) |
| AU (1) | AU2014372575B2 (es) |
| BR (1) | BR112016014578B1 (es) |
| CA (1) | CA2934470C (es) |
| ES (1) | ES2865723T3 (es) |
| IL (1) | IL246435B (es) |
| MX (1) | MX375204B (es) |
| NZ (1) | NZ721332A (es) |
| RU (1) | RU2695343C2 (es) |
| SG (1) | SG11201604927RA (es) |
| WO (1) | WO2015097233A1 (es) |
| ZA (1) | ZA201604609B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2698210C2 (ru) | 2013-12-24 | 2019-08-23 | Арес Трейдинг С.А. | Состав fgf-18 в альгинатных/коллагеновых гидрогелях |
| EP3250925B1 (en) | 2015-01-29 | 2019-04-10 | Ares Trading S.A. | Immunoassays for highly positively charged proteins |
| CN111163791A (zh) | 2017-09-29 | 2020-05-15 | 默克专利有限公司 | 预测对fgf-18化合物反应性的代谢生物标志物 |
| LT3688468T (lt) | 2017-09-29 | 2022-06-27 | Merck Patent Gmbh | Uždegiminiai biožymenys, skirti atsako į fgf-18 junginį numatymui |
| KR20210057764A (ko) | 2018-09-10 | 2021-05-21 | 메르크 파텐트 게엠베하 | 골관절염의 치료를 위한 강화 전략에 유용한 마커 |
| WO2024084807A1 (ja) * | 2022-10-19 | 2024-04-25 | 学校法人東邦大学 | 線維芽細胞増殖因子１８の測定方法及び測定用試薬 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4259613B2 (ja) * | 1996-02-13 | 2009-04-30 | 大日本住友製薬株式会社 | ガラクトキシログルカンを用いるドラッグ・デリバリー・システム |
| EP2322226A3 (en) * | 1999-07-21 | 2011-08-17 | Omeros Corporation | Solutions and methods for inhibition of pain, inflammation and cartilage degradation |
| CA2500742C (en) * | 2002-10-07 | 2014-02-18 | Zymogenetics, Inc. | Compositions of fgf-18 and hyaluronic acid for stimulating cartilage production and treating osteoarthritis |
| US7217294B2 (en) * | 2003-08-20 | 2007-05-15 | Histogenics Corp. | Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof |
| EA015644B1 (ru) | 2006-08-25 | 2011-10-31 | Арес Трейдинг С.А. | Способ лечения заболеваний хряща |
| CN102600066A (zh) * | 2012-04-01 | 2012-07-25 | 山东喜丰田生态肥业有限公司 | 一种含有扑热息痛的温度敏感凝胶缓释口服剂 |
| WO2014062538A1 (en) * | 2012-10-19 | 2014-04-24 | 3M Innovative Properties Company | Polysaccharide-containing hydrogels, compositions, articles, and methods |
| RU2698210C2 (ru) | 2013-12-24 | 2019-08-23 | Арес Трейдинг С.А. | Состав fgf-18 в альгинатных/коллагеновых гидрогелях |
-
2014
- 2014-12-23 AU AU2014372575A patent/AU2014372575B2/en active Active
- 2014-12-23 MX MX2016008441A patent/MX375204B/es active IP Right Grant
- 2014-12-23 EP EP14833347.9A patent/EP3086803B1/en active Active
- 2014-12-23 CA CA2934470A patent/CA2934470C/en active Active
- 2014-12-23 NZ NZ721332A patent/NZ721332A/en unknown
- 2014-12-23 RU RU2016129827A patent/RU2695343C2/ru active
- 2014-12-23 CN CN201480076248.4A patent/CN106029085B/zh active Active
- 2014-12-23 BR BR112016014578-0A patent/BR112016014578B1/pt active IP Right Grant
- 2014-12-23 JP JP2016542700A patent/JP6791754B2/ja active Active
- 2014-12-23 WO PCT/EP2014/079194 patent/WO2015097233A1/en not_active Ceased
- 2014-12-23 KR KR1020227012532A patent/KR102622290B1/ko active Active
- 2014-12-23 SG SG11201604927RA patent/SG11201604927RA/en unknown
- 2014-12-23 KR KR1020167019785A patent/KR20160102032A/ko not_active Ceased
- 2014-12-23 ES ES14833347T patent/ES2865723T3/es active Active
- 2014-12-23 US US15/105,622 patent/US10293051B2/en active Active
-
2016
- 2016-06-23 IL IL246435A patent/IL246435B/en active IP Right Grant
- 2016-07-06 ZA ZA2016/04609A patent/ZA201604609B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2934470A1 (en) | 2015-07-02 |
| ZA201604609B (en) | 2022-05-25 |
| JP6791754B2 (ja) | 2020-11-25 |
| RU2695343C2 (ru) | 2019-07-23 |
| IL246435A0 (en) | 2016-08-31 |
| EP3086803B1 (en) | 2021-02-17 |
| BR112016014578B1 (pt) | 2023-01-24 |
| CN106029085B (zh) | 2020-08-04 |
| WO2015097233A1 (en) | 2015-07-02 |
| MX2016008441A (es) | 2017-01-11 |
| KR20220054446A (ko) | 2022-05-02 |
| KR20160102032A (ko) | 2016-08-26 |
| KR102622290B1 (ko) | 2024-01-05 |
| RU2016129827A3 (es) | 2018-09-03 |
| CN106029085A (zh) | 2016-10-12 |
| JP2017502043A (ja) | 2017-01-19 |
| CA2934470C (en) | 2023-06-27 |
| RU2016129827A (ru) | 2018-01-30 |
| SG11201604927RA (en) | 2016-07-28 |
| IL246435B (en) | 2021-03-25 |
| US20160317668A1 (en) | 2016-11-03 |
| AU2014372575A1 (en) | 2016-07-07 |
| ES2865723T3 (es) | 2021-10-15 |
| BR112016014578A2 (pt) | 2017-10-24 |
| EP3086803A1 (en) | 2016-11-02 |
| NZ721332A (en) | 2022-07-01 |
| US10293051B2 (en) | 2019-05-21 |
| AU2014372575B2 (en) | 2020-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |