MX374472B - Composiciones y métodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva. - Google Patents
Composiciones y métodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva.Info
- Publication number
- MX374472B MX374472B MX2016012176A MX2016012176A MX374472B MX 374472 B MX374472 B MX 374472B MX 2016012176 A MX2016012176 A MX 2016012176A MX 2016012176 A MX2016012176 A MX 2016012176A MX 374472 B MX374472 B MX 374472B
- Authority
- MX
- Mexico
- Prior art keywords
- tumor
- cell therapy
- adoptive cell
- infiltrating lymphocytes
- disclosed
- Prior art date
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4271—Melanoma antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
- C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
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- Urology & Nephrology (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
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- General Physics & Mathematics (AREA)
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- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Dermatology (AREA)
Abstract
La presente invención se refiere a composiciones y métodos para la expansión ex vivo de linfocitos infiltrantes de tumor para usar en la terapia celular adoptiva (ACT). También se describen composiciones y métodos para identificar un agente para la expansión ex vivo de linfocitos infiltrantes de tumor para usar en la ACT. También se describen métodos para el tratamiento del cáncer usando linfocitos infiltrantes de tumor expandidos mediante los métodos descritos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461955970P | 2014-03-20 | 2014-03-20 | |
| US201461973002P | 2014-03-31 | 2014-03-31 | |
| PCT/US2015/021759 WO2015143328A1 (en) | 2014-03-20 | 2015-03-20 | Tumor-infiltrating lymphocytes for adoptive cell therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016012176A MX2016012176A (es) | 2017-04-13 |
| MX374472B true MX374472B (es) | 2025-03-06 |
Family
ID=54145388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016012176A MX374472B (es) | 2014-03-20 | 2015-03-20 | Composiciones y métodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva. |
| MX2020005634A MX2020005634A (es) | 2014-03-20 | 2016-09-20 | Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020005634A MX2020005634A (es) | 2014-03-20 | 2016-09-20 | Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva. |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20170081635A1 (es) |
| EP (2) | EP3119477B1 (es) |
| JP (4) | JP2017511375A (es) |
| KR (3) | KR20230085225A (es) |
| CN (2) | CN112080467A (es) |
| AU (3) | AU2015231041B2 (es) |
| CA (1) | CA2943389C (es) |
| EA (1) | EA036386B1 (es) |
| ES (1) | ES2776407T3 (es) |
| MX (2) | MX374472B (es) |
| WO (1) | WO2015143328A1 (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA036386B1 (ru) | 2014-03-20 | 2020-11-03 | Х. Ли Моффитт Кэнсер Сентер Энд Рисёч Инститьют, Инк. | Проникающие в опухоль лимфоциты для адоптивной клеточной терапии |
| ES2980788T3 (es) | 2014-04-10 | 2024-10-03 | H Lee Moffitt Cancer Ct & Res | Expansión mejorada de linfocitos infiltrantes de tumores para terapia celular adoptiva |
| IL257105B (en) | 2015-07-31 | 2022-09-01 | Univ Minnesota | Modified cells and methods of therapy |
| EP3228701A1 (en) * | 2016-04-05 | 2017-10-11 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Method for preparing lymphocytes capable of infiltrating a solid tumor, lymphocytes obtainable by said method and uses thereof |
| MA45595A (fr) | 2016-07-07 | 2019-05-15 | Iovance Biotherapeutics Inc | Protéines de liaison au ligand (1) de mort programmée (1) (pd-l1) et leurs procédés d'utilisation |
| JP7181862B2 (ja) | 2016-10-18 | 2022-12-01 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 腫瘍浸潤リンパ球および治療の方法 |
| JP2019532652A (ja) | 2016-10-26 | 2019-11-14 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 凍結保存腫瘍浸潤リンパ球の再刺激 |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| BR112019009925A2 (pt) | 2016-11-17 | 2019-10-08 | Iovance Biotherapeutics Inc | método para preparar linfócitos infiltrantes de tumor remanescente para terapia de células t adotivas, e, método de tratamento de um câncer . |
| CA3049165A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| AU2018227810A1 (en) * | 2017-03-01 | 2019-08-29 | Nektar Therapeutics | Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| PE20251254A1 (es) | 2017-05-24 | 2025-05-06 | Novartis Ag | Proteinas de anticuerpo injertadas con citocina y metodos de uso en el tratamiento del cancer |
| US11819517B2 (en) * | 2017-06-05 | 2023-11-21 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
| JP2020530307A (ja) | 2017-06-30 | 2020-10-22 | インティマ・バイオサイエンス,インコーポレーテッド | 遺伝子治療のためのアデノ随伴ウイルスベクター |
| BR112020013848A2 (pt) | 2018-01-08 | 2020-12-01 | Iovance Biotherapeutics, Inc. | métodos para expandir linfócitos infiltrantes de tumor e para tratar um indivíduo com câncer, população de linfócitos infiltrantes de tumor, e, método para avaliar fatores de transcrição |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| GB201801067D0 (en) * | 2018-01-23 | 2018-03-07 | Price Nicola Kaye | Biomarkers predictive of tumour infiltrating lymphocyte therapy and uses thereof |
| JP7558563B2 (ja) | 2018-03-15 | 2024-10-01 | ケーエスキュー セラピューティクス, インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| US20210130779A1 (en) | 2018-04-27 | 2021-05-06 | Iovance Biotherapeutics, Inc. | Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| CN108486120B (zh) * | 2018-04-28 | 2019-12-06 | 新乡医学院 | 一种新型CpG ODN序列及其在抗黑色素瘤上的应用 |
| US12473532B2 (en) | 2018-05-10 | 2025-11-18 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| ES3036072T3 (en) | 2018-11-05 | 2025-09-12 | Iovance Biotherapeutics Inc | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| GB201911066D0 (en) | 2019-08-02 | 2019-09-18 | Achilles Therapeutics Ltd | T cell therapy |
| TW202206592A (zh) | 2020-04-22 | 2022-02-16 | 美商艾歐凡斯生物治療公司 | 用於協調產製供病患特異性免疫治療之細胞的系統和方法 |
| KR20230017786A (ko) | 2020-04-28 | 2023-02-06 | 라이엘 이뮤노파마, 인크. | 세포 배양 방법 |
| CA3176654A1 (en) | 2020-04-28 | 2021-11-04 | Karl PEGGS | T cell therapy |
| AU2021368569A1 (en) * | 2020-10-27 | 2023-06-08 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Oncolytic virus boosts t cell response for effective til therapy |
| GB202109886D0 (en) | 2021-07-08 | 2021-08-25 | Achilles Therapeutics Uk Ltd | Assay |
| EP4320435A1 (en) | 2021-04-09 | 2024-02-14 | Achilles Therapeutics UK Limited | Batch release assay for pharmaceutical products relating to t cell therapies |
| US20240287456A1 (en) | 2021-06-22 | 2024-08-29 | Achilles Therapeutics Uk Limited | A method for producing antigen-specific t cells |
| US20230270784A1 (en) * | 2021-12-07 | 2023-08-31 | Memgen, Inc. | Oncolytic virus boosts t cell response for effective til therapy |
| WO2023201369A1 (en) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
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| US5811515A (en) | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| DK2332968T3 (en) | 2003-11-05 | 2016-08-22 | Dana Farber Cancer Inst Inc | Alpha-helix peptides suitable for activating or inhibiting cell death |
| US7858743B2 (en) * | 2004-09-09 | 2010-12-28 | Ludwig Institute For Cancer Research | SSX-4 peptides presented by HLA class II molecules |
| PT2327763T (pt) * | 2005-08-05 | 2018-05-11 | Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh | Geração de células t específicas de antigénios |
| WO2007071389A1 (en) * | 2005-12-21 | 2007-06-28 | Sentoclone Ab | Method for treating disseminated cancer |
| KR101525754B1 (ko) | 2007-03-28 | 2015-06-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
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| BR112012009962A2 (pt) * | 2009-10-27 | 2015-09-15 | Immunicum Ab | método para a proliferação de células tantígeno específicas. |
| WO2012127464A2 (en) * | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Constitutively activated t cells for use in adoptive cell therapy |
| WO2013192628A1 (en) | 2012-06-22 | 2013-12-27 | University Of South Florida | Peptoid-peptide hybrids and their use |
| CN103243072B (zh) * | 2013-05-09 | 2016-03-02 | 杭州中赢生物医疗科技有限公司 | CD8α-白介素21片段-CD137复合物扩增激活淋巴细胞的方法 |
| CN103396992A (zh) * | 2013-08-15 | 2013-11-20 | 中国人民解放军第二军医大学 | 寡克隆肝癌肿瘤浸润淋巴细胞的培养和应用 |
| CN103520198B (zh) * | 2013-09-24 | 2016-01-20 | 彭光勇 | 一种制备用于阻止肿瘤细胞诱导t细胞老化并逆转其免疫抑制能力的药物的方法及其在抗肿瘤免疫治疗中的用途 |
| EA036386B1 (ru) * | 2014-03-20 | 2020-11-03 | Х. Ли Моффитт Кэнсер Сентер Энд Рисёч Инститьют, Инк. | Проникающие в опухоль лимфоциты для адоптивной клеточной терапии |
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2015
- 2015-03-20 EA EA201691866A patent/EA036386B1/ru unknown
- 2015-03-20 CA CA2943389A patent/CA2943389C/en active Active
- 2015-03-20 JP JP2017501131A patent/JP2017511375A/ja active Pending
- 2015-03-20 CN CN202010876959.7A patent/CN112080467A/zh active Pending
- 2015-03-20 US US15/126,436 patent/US20170081635A1/en not_active Abandoned
- 2015-03-20 KR KR1020237018885A patent/KR20230085225A/ko not_active Ceased
- 2015-03-20 MX MX2016012176A patent/MX374472B/es active IP Right Grant
- 2015-03-20 WO PCT/US2015/021759 patent/WO2015143328A1/en not_active Ceased
- 2015-03-20 CN CN201580022690.3A patent/CN106659913A/zh active Pending
- 2015-03-20 KR KR1020247039885A patent/KR20250004905A/ko active Pending
- 2015-03-20 KR KR1020167029042A patent/KR20160146713A/ko not_active Ceased
- 2015-03-20 EP EP15765854.3A patent/EP3119477B1/en active Active
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- 2015-03-20 EP EP19220121.8A patent/EP3698850A1/en active Pending
- 2015-03-20 AU AU2015231041A patent/AU2015231041B2/en active Active
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2016
- 2016-09-20 MX MX2020005634A patent/MX2020005634A/es unknown
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2019
- 2019-02-11 US US16/272,524 patent/US11518980B2/en active Active
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2020
- 2020-07-15 JP JP2020121328A patent/JP2020182477A/ja active Pending
- 2020-10-15 AU AU2020256412A patent/AU2020256412A1/en not_active Abandoned
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2022
- 2022-05-24 US US17/752,481 patent/US12291724B2/en active Active
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2023
- 2023-01-20 AU AU2023200308A patent/AU2023200308A1/en not_active Abandoned
- 2023-07-10 JP JP2023113229A patent/JP2023123877A/ja active Pending
-
2024
- 2024-12-19 JP JP2024224484A patent/JP2025041755A/ja active Pending
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