MX370006B - Derivados de piperazina y su uso como medicamento. - Google Patents

Derivados de piperazina y su uso como medicamento.

Info

Publication number
MX370006B
MX370006B MX2016004847A MX2016004847A MX370006B MX 370006 B MX370006 B MX 370006B MX 2016004847 A MX2016004847 A MX 2016004847A MX 2016004847 A MX2016004847 A MX 2016004847A MX 370006 B MX370006 B MX 370006B
Authority
MX
Mexico
Prior art keywords
piperazine derivatives
medicament
compounds
general formula
glyt1
Prior art date
Application number
MX2016004847A
Other languages
English (en)
Spanish (es)
Other versions
MX2016004847A (es
Inventor
Hoenke Christoph
Rosenbrock Holger
Giovannini Riccardo
Lessel Uta
Schmid Bernhard
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2016004847A publication Critical patent/MX2016004847A/es
Publication of MX370006B publication Critical patent/MX370006B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MX2016004847A 2013-10-16 2014-10-15 Derivados de piperazina y su uso como medicamento. MX370006B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13188904 2013-10-16
PCT/EP2014/072085 WO2015055698A1 (en) 2013-10-16 2014-10-15 Piperazine derivatives and the use thereof as medicament

Publications (2)

Publication Number Publication Date
MX2016004847A MX2016004847A (es) 2016-07-19
MX370006B true MX370006B (es) 2019-11-28

Family

ID=49354583

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016004847A MX370006B (es) 2013-10-16 2014-10-15 Derivados de piperazina y su uso como medicamento.

Country Status (21)

Country Link
US (1) US9233953B2 (enExample)
EP (1) EP3057963B1 (enExample)
JP (1) JP6483105B2 (enExample)
KR (1) KR102281284B1 (enExample)
CN (1) CN105636961B (enExample)
AR (1) AR098037A1 (enExample)
AU (1) AU2014336258B2 (enExample)
BR (1) BR112016008062B1 (enExample)
CA (1) CA2926754C (enExample)
CL (1) CL2016000884A1 (enExample)
DK (1) DK3057963T3 (enExample)
EA (1) EA029313B1 (enExample)
ES (1) ES2745555T3 (enExample)
HU (1) HUE047044T2 (enExample)
IL (1) IL244693B (enExample)
MX (1) MX370006B (enExample)
PH (1) PH12016500577B1 (enExample)
PL (1) PL3057963T3 (enExample)
TW (1) TW201609716A (enExample)
UY (1) UY35785A (enExample)
WO (1) WO2015055698A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106854189A (zh) * 2015-12-08 2017-06-16 湖南华腾制药有限公司 一种哌嗪化合物的合成方法
CN107778257A (zh) * 2016-08-29 2018-03-09 湖南华腾制药有限公司 一种哌嗪衍生物的合成方法
CN106977463A (zh) * 2017-05-31 2017-07-25 湖南华腾制药有限公司 一种联苯取代哌嗪衍生物的合成方法
CN107417679A (zh) * 2017-08-04 2017-12-01 河南农业大学 1,3‑唑类取代吡嗪类化合物的制备方法
KR20220125326A (ko) 2020-01-09 2022-09-14 디스크 메디슨, 인크. 적혈구형성 프로토포르피린증, x-연계된 프로토포르피린증, 또는 선천성 적혈구 조혈포르피린증을 글리신 운반 억제제로 치료하는 방법
CN117050051B (zh) * 2023-08-14 2026-05-26 上海药坦药物研究开发有限公司 一种2-溴-1-(5-碘噻吩-2-基)-乙酮的纯化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0224084D0 (en) * 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
GB0505085D0 (en) 2005-03-11 2005-04-20 Glaxo Group Ltd Compounds
EP1871762A2 (en) * 2005-04-18 2008-01-02 Neurogen Corporation Subtituted heteroaryl cb1 antagonists
JP5690823B2 (ja) * 2009-07-08 2015-03-25 レオ ファーマ アクティーゼルスカブ Jak受容体およびタンパク質チロシンキナーゼ阻害薬としての複素環化合物

Also Published As

Publication number Publication date
PL3057963T3 (pl) 2019-12-31
CN105636961A (zh) 2016-06-01
EA029313B1 (ru) 2018-03-30
ES2745555T3 (es) 2020-03-02
JP6483105B2 (ja) 2019-03-13
NZ718251A (en) 2021-02-26
IL244693B (en) 2019-08-29
PH12016500577A1 (en) 2016-06-20
CA2926754C (en) 2021-09-14
BR112016008062B1 (pt) 2022-11-16
WO2015055698A1 (en) 2015-04-23
AR098037A1 (es) 2016-04-27
DK3057963T3 (da) 2019-09-16
TW201609716A (zh) 2016-03-16
MX2016004847A (es) 2016-07-19
AU2014336258A1 (en) 2016-04-14
CL2016000884A1 (es) 2016-12-30
EP3057963B1 (en) 2019-06-19
CN105636961B (zh) 2019-11-05
EP3057963A1 (en) 2016-08-24
US9233953B2 (en) 2016-01-12
US20150105397A1 (en) 2015-04-16
KR20160062187A (ko) 2016-06-01
KR102281284B1 (ko) 2021-07-23
AU2014336258B2 (en) 2018-07-12
PH12016500577B1 (en) 2016-06-20
BR112016008062A2 (enExample) 2017-08-01
IL244693A0 (en) 2016-04-21
CA2926754A1 (en) 2015-04-23
EA201600323A1 (ru) 2016-10-31
JP2016533368A (ja) 2016-10-27
UY35785A (es) 2015-04-30
HUE047044T2 (hu) 2020-04-28

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