MX369207B - Modulación de la expresión del receptor androgénico. - Google Patents

Modulación de la expresión del receptor androgénico.

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Publication number
MX369207B
MX369207B MX2015004641A MX2015004641A MX369207B MX 369207 B MX369207 B MX 369207B MX 2015004641 A MX2015004641 A MX 2015004641A MX 2015004641 A MX2015004641 A MX 2015004641A MX 369207 B MX369207 B MX 369207B
Authority
MX
Mexico
Prior art keywords
androgen receptor
inhibiting
cancer
modulation
cell
Prior art date
Application number
MX2015004641A
Other languages
English (en)
Other versions
MX2015004641A (es
Inventor
M Freier Susan
A Macleod Robert
Kim Youngsoo
Zhou Tianyuan
P Seth Punit
Swayze Eric
P Monia Brett
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50475891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX369207(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2015004641A publication Critical patent/MX2015004641A/es
Publication of MX369207B publication Critical patent/MX369207B/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Medicinal Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Biotechnology (AREA)
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  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a compuestos y composiciones que tienen como objetivo un receptor de andrógenos (AR) humano para inhibir los niveles del receptor de andrógenos en una célula, lo cual puede resultar útil en métodos de tratamiento del cáncer y de inhibición del crecimiento o la proliferación de células cancerosas. Varias modalidades proporcionadas en este documento se refieren al descubrimiento de compuestos y composiciones para inhibir los niveles del receptor de andrógenos en una célula, que puede ser útil para métodos de tratamiento del cáncer y la inhibición de la proliferación o crecimiento de células cancerosas, como el cáncer de próstata, mama, ovario, gástrico o vejiga o células cancerosas.
MX2015004641A 2012-10-11 2013-10-11 Modulación de la expresión del receptor androgénico. MX369207B (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261712756P 2012-10-11 2012-10-11
US201261712780P 2012-10-11 2012-10-11
US201261723701P 2012-11-07 2012-11-07
US201361777813P 2013-03-12 2013-03-12
US201361777895P 2013-03-12 2013-03-12
US201361777851P 2013-03-12 2013-03-12
PCT/US2013/064479 WO2014059238A2 (en) 2012-10-11 2013-10-11 Modulation of androgen receptor expression

Publications (2)

Publication Number Publication Date
MX2015004641A MX2015004641A (es) 2015-07-14
MX369207B true MX369207B (es) 2019-10-31

Family

ID=50475891

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015004641A MX369207B (es) 2012-10-11 2013-10-11 Modulación de la expresión del receptor androgénico.

Country Status (31)

Country Link
US (3) US9175291B2 (es)
EP (1) EP2906226B1 (es)
JP (2) JP6306598B2 (es)
KR (1) KR102124228B1 (es)
CN (2) CN104703610B (es)
AP (1) AP2015008368A0 (es)
AR (1) AR092982A1 (es)
AU (2) AU2013329070A1 (es)
BR (1) BR112015007878A2 (es)
CA (1) CA2887867C (es)
CL (1) CL2015000901A1 (es)
CO (1) CO7400882A2 (es)
DK (1) DK2906226T3 (es)
DO (1) DOP2015000083A (es)
EC (1) ECSP15012462A (es)
ES (1) ES2706387T3 (es)
IL (2) IL237855A0 (es)
MX (1) MX369207B (es)
NI (1) NI201500051A (es)
NZ (1) NZ706151A (es)
PE (1) PE20150722A1 (es)
PH (1) PH12015500788A1 (es)
PL (1) PL2906226T3 (es)
PT (1) PT2906226T (es)
RU (1) RU2670486C9 (es)
SG (1) SG11201502505UA (es)
TN (1) TN2015000140A1 (es)
TW (1) TW201420594A (es)
UY (1) UY35078A (es)
WO (1) WO2014059238A2 (es)
ZA (1) ZA201503203B (es)

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