MX369056B - Prevención, interrupción y tratamiento de biopelículas con lisina de bacteriófago. - Google Patents

Prevención, interrupción y tratamiento de biopelículas con lisina de bacteriófago.

Info

Publication number
MX369056B
MX369056B MX2014013587A MX2014013587A MX369056B MX 369056 B MX369056 B MX 369056B MX 2014013587 A MX2014013587 A MX 2014013587A MX 2014013587 A MX2014013587 A MX 2014013587A MX 369056 B MX369056 B MX 369056B
Authority
MX
Mexico
Prior art keywords
treatment
disruption
lysin
bacteriophage lysin
biofilm
Prior art date
Application number
MX2014013587A
Other languages
English (en)
Spanish (es)
Other versions
MX2014013587A (es
Inventor
Michael Wittekind
Raymond Schuch
Robert C Nowinski
Babar Khan
Jimmy Rotolo
Original Assignee
Contrafect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contrafect Corp filed Critical Contrafect Corp
Publication of MX2014013587A publication Critical patent/MX2014013587A/es
Publication of MX369056B publication Critical patent/MX369056B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/40—Viruses, e.g. bacteriophages
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MX2014013587A 2012-05-09 2013-05-09 Prevención, interrupción y tratamiento de biopelículas con lisina de bacteriófago. MX369056B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261644799P 2012-05-09 2012-05-09
US201261736813P 2012-12-13 2012-12-13
PCT/US2013/040340 WO2013170022A1 (en) 2012-05-09 2013-05-09 Biofilm prevention, disruption and treatment with bacteriophage lysin

Publications (2)

Publication Number Publication Date
MX2014013587A MX2014013587A (es) 2015-07-06
MX369056B true MX369056B (es) 2019-10-28

Family

ID=49551275

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014013587A MX369056B (es) 2012-05-09 2013-05-09 Prevención, interrupción y tratamiento de biopelículas con lisina de bacteriófago.
MX2019012877A MX2019012877A (es) 2012-05-09 2014-11-07 Prevencion, interrupcion y tratamiento de biopeliculas con lisina de bacteriofago.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019012877A MX2019012877A (es) 2012-05-09 2014-11-07 Prevencion, interrupcion y tratamiento de biopeliculas con lisina de bacteriofago.

Country Status (16)

Country Link
US (4) US9499594B2 (enExample)
EP (2) EP2846827B1 (enExample)
JP (4) JP6348901B2 (enExample)
KR (4) KR20230135161A (enExample)
CN (2) CN111803620A (enExample)
AU (3) AU2013259427B2 (enExample)
BR (1) BR112014027818B1 (enExample)
CA (2) CA3187222A1 (enExample)
DK (1) DK2846827T3 (enExample)
ES (1) ES2729123T3 (enExample)
HK (1) HK1212208A1 (enExample)
IL (2) IL235526B2 (enExample)
IN (1) IN2014MN02438A (enExample)
MX (2) MX369056B (enExample)
RU (3) RU2735103C2 (enExample)
WO (1) WO2013170022A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008143889A1 (en) 2007-05-14 2008-11-27 Research Foundation Of State University Of New York Induction of a physiological dispersion response in bacterial cells in a biofilm
KR102310387B1 (ko) * 2012-05-09 2021-10-13 콘트라펙트 코포레이션 그람 양성 박테리아에 대한 박테리오파지 리신과 항생제의 병용물
KR102441211B1 (ko) 2014-06-26 2022-09-07 더 락커펠러 유니버시티 아시네토박터 라이신
CN104805066B (zh) * 2015-05-18 2018-04-24 武汉菲吉乐科生物科技有限公司 一种葡萄球菌裂解酶及其应用
EP3120866A1 (en) * 2015-07-24 2017-01-25 Zymetech ehf. Use of marine serine proteases for removal, prevention and inhibition of formation and growth of biofilms
US11103547B2 (en) 2016-02-04 2021-08-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods for disrupting biofilms
EP3416669B1 (en) * 2016-02-19 2025-05-28 Klaus Brandenburg Means and methods for treating bacterial infections
RU2664708C1 (ru) * 2017-06-08 2018-08-21 Сергей Иванович Черныш Способ разрушения и предотвращения образования бактериальных биопленок комплексом антимикробных пептидов насекомых
JP2021513865A (ja) * 2018-02-26 2021-06-03 コントラフェクト コーポレイション 修飾ＰｌｙＳｓ２溶解素及びその使用
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3941504A4 (en) * 2019-03-22 2022-12-07 Contrafect Corporation METHOD FOR TREATING INFECTIOUS ENDOCARDITIS
US20220193186A1 (en) * 2019-04-11 2022-06-23 Contrafect Corporation Method of treating and preventing bone and joint infections
KR102097128B1 (ko) * 2019-06-19 2020-04-06 서울대학교산학협력단 황색포도상구균 제어에 효과적인 키메릭 엔도라이신 Lys109
CN111019876B (zh) * 2019-12-30 2023-04-28 延安大学 一种铜绿假单胞菌工程菌的构建方法及应用
US20230277632A1 (en) * 2020-05-19 2023-09-07 Contrafect Corporation MODIFIED PlySs2 LYSINS AND ANTIBIOTIC COMBINATIONS FOR USE AGAINST GRAM-POSITIVE BACTERIA
KR102426421B1 (ko) * 2021-01-06 2022-07-29 주식회사 리신바이오 신규 재조합 엔도라이신 및 이의 용도
WO2024007055A1 (en) * 2022-07-05 2024-01-11 The University Of Adelaide Method of production of modified phage and method of treatment using same
CN120513297A (zh) * 2023-01-09 2025-08-19 华中农业大学 细菌裂解酶及其应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988002781A1 (en) 1986-10-08 1988-04-21 David Bernstein Method for exposing group a streptococcal antigens and an improved diagnostic test for the identification of group a streptococci
US6254866B1 (en) 1997-10-31 2001-07-03 New Horizons Diagnostics Corporation Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract
US6248324B1 (en) 1997-10-31 2001-06-19 Vincent Fischetti Bacterial phage associated lysing enzymes for treating dermatological infections
US20060292135A1 (en) 1997-10-31 2006-12-28 Lawrence Loomis Use of bacterial phage-associated lysing proteins for preventing and treating bacterial infections in humans, animals and fowl
US5997862A (en) 1997-10-31 1999-12-07 New Horizons Diagnostics Corporation Therapeutic treatment of group A streptococcal infections
US6264945B1 (en) 1997-10-31 2001-07-24 Vincent A Fischetti Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
MXPA01008701A (es) 1999-02-25 2003-06-24 New Horizons Diagnostics Inc Un medio para el tratameinto profilactico y terapeutico de infecciones estreptococicas.
US6056955A (en) 1999-09-14 2000-05-02 Fischetti; Vincent Topical treatment of streptococcal infections
US20040213765A1 (en) 2001-07-13 2004-10-28 Vincent Fischetti Use of bacterial phage associated lytic enzymes to prevent food poisoning
EP1501925A4 (en) 2002-05-17 2006-10-25 New Horizons Diagnostics Corp IDENTIFICATION OF A LYTIC ENZYME ASSOCIATED WITH A PHAGE TO DETECT AND ELIMINATE RAPIDLY AND SPECIFICALLY BACILLUS ANTHRACIS
US7569223B2 (en) 2004-03-22 2009-08-04 The Rockefeller University Phage-associated lytic enzymes for treatment of Streptococcus pneumoniae and related conditions
US7638600B2 (en) 2004-03-24 2009-12-29 The Rockefeller University Lytic enzymes and spore surface antigen for detection and treatment of Bacillus anthracis bacteria and spores
EP1621205A1 (en) * 2004-07-28 2006-02-01 OctoPlus Technologies B.V. Antimicrobial peptides derived from CAP18
MX2007003402A (es) * 2004-09-22 2007-05-10 Glaxosmithkline Biolog Sa Composicion inmunogena para su uso en vacunacion contra estafilococos.
US8389469B2 (en) 2005-06-06 2013-03-05 The Rockefeller University Bacteriophage lysins for Bacillus anthracis
US7582291B2 (en) 2005-06-30 2009-09-01 The Rockefeller University Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
CA2620903A1 (en) 2005-08-24 2007-03-01 The Rockefeller University Ply-gbs mutant lysins
US20080019956A1 (en) * 2006-07-24 2008-01-24 Manoj Kumar Enzymatic prevention and control of biofilm
EP2185699B1 (en) * 2007-08-22 2017-11-22 Hyglos Invest GmbH New proteins for use in human and animal staphylococcus infections
EP2238157A2 (en) * 2008-01-10 2010-10-13 Trustees of Boston University Engineered bacteriophages as adjuvants for antimicrobial agents and compositions and methods of use thereof
US8840900B2 (en) * 2008-07-03 2014-09-23 The Rockefeller University Chimeric bacteriophage lysin with activity against Staphylococci bacteria
EP2899268A1 (en) * 2008-10-10 2015-07-29 Lusomedicamenta, S.A. Antibacterial phage peptides and methods of use thereof
KR101016918B1 (ko) 2009-01-08 2011-02-25 주식회사 인트론바이오테크놀로지 박테리아 특이적 넓은 항균 활성을 갖는 신규한 리신 단백질
KR101676063B1 (ko) 2009-05-01 2016-11-14 키모토 컴파니 리미티드 이형성 조성물 및 표면 보호 필름
EP2338916A1 (en) * 2009-12-23 2011-06-29 Hyglos Invest GmbH Chimeric polypeptides and their use in bacterial decoloniation
CN103080307A (zh) 2010-01-25 2013-05-01 美艾利尔斯卡保罗有限公司 A25噬菌体溶解酶
BR112012026880B1 (pt) * 2010-04-27 2021-03-16 Lysando Ag método para eliminação ou redução de um biofilme bacteriano, variante de endolisina ou variante de bacteriocina e seus usos
EP2397548A1 (en) * 2010-06-18 2011-12-21 Hyglos Invest GmbH Methods of generating and screening for lytic chimeric polypeptides
US9034322B2 (en) 2011-04-21 2015-05-19 The Rockefeller University Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
WO2012145573A2 (en) * 2011-04-21 2012-10-26 Universiteit Utrecht Holding Bv Streptococcus bacteriophage lysins for treatment of gram positive bacteria in companion animals and livestock
EP2702070B1 (en) 2011-04-27 2015-09-30 Lysando AG New antimicrobial agents
KR102310387B1 (ko) 2012-05-09 2021-10-13 콘트라펙트 코포레이션 그람 양성 박테리아에 대한 박테리오파지 리신과 항생제의 병용물
EP2835193A1 (en) 2013-08-05 2015-02-11 Refractory Intellectual Property GmbH & Co. KG Refractory ceramic nozzle
CN104073478A (zh) * 2014-06-13 2014-10-01 上海交通大学 杀灭革兰氏阳性菌的酶抗生素及其制备、用途
CN104726439B (zh) * 2015-04-13 2017-11-14 武汉菲吉乐科生物科技有限公司 一种广谱的链球菌裂解酶及其应用
CN104805066B (zh) * 2015-05-18 2018-04-24 武汉菲吉乐科生物科技有限公司 一种葡萄球菌裂解酶及其应用
MX2018003100A (es) * 2015-09-17 2019-04-15 Contrafect Corp Uso de lisina para restaurar/aumentar la actividad antibacteriana en presencia de agente tensoactivo pulmonar de antibioticos inhibidos en el mismo.

Also Published As

Publication number Publication date
IL269426A (en) 2019-11-28
KR20210118980A (ko) 2021-10-01
AU2018201736A1 (en) 2018-04-12
IL235526A0 (en) 2015-01-29
RU2018102796A (ru) 2019-02-22
MX2014013587A (es) 2015-07-06
US20190387745A1 (en) 2019-12-26
RU2020133461A (ru) 2022-04-12
IN2014MN02438A (enExample) 2015-07-10
JP6873939B2 (ja) 2021-05-19
KR20230135161A (ko) 2023-09-22
JP2018087242A (ja) 2018-06-07
ES2729123T3 (es) 2019-10-30
CA3187222A1 (en) 2013-11-14
CN111803620A (zh) 2020-10-23
US9499594B2 (en) 2016-11-22
CA2872911A1 (en) 2013-11-14
US20150111813A1 (en) 2015-04-23
KR20200023521A (ko) 2020-03-04
EP2846827A1 (en) 2015-03-18
JP2020189860A (ja) 2020-11-26
EP2846827A4 (en) 2016-03-02
WO2013170022A1 (en) 2013-11-14
CA2872911C (en) 2023-10-03
HK1208366A1 (en) 2016-03-04
AU2013259427A1 (en) 2014-12-11
EP3513807A1 (en) 2019-07-24
CN104780933A (zh) 2015-07-15
RU2018102796A3 (enExample) 2019-02-22
JP7368018B2 (ja) 2023-10-24
US11524046B2 (en) 2022-12-13
RU2646102C2 (ru) 2018-03-01
AU2020204014A1 (en) 2020-07-02
KR102084388B1 (ko) 2020-03-06
AU2013259427B2 (en) 2017-12-14
CN104780933B (zh) 2020-08-28
JP2015521178A (ja) 2015-07-27
KR20150039129A (ko) 2015-04-09
AU2018201736B2 (en) 2020-03-19
DK2846827T3 (da) 2019-05-13
BR112014027818B1 (pt) 2023-03-28
MX2019012877A (es) 2020-01-14
US20170127683A1 (en) 2017-05-11
EP2846827B1 (en) 2019-02-13
BR112014027818A2 (pt) 2017-08-08
HK1212208A1 (en) 2016-06-10
JP6348901B2 (ja) 2018-06-27
RU2014149348A (ru) 2016-07-10
JP2022163214A (ja) 2022-10-25
RU2735103C2 (ru) 2020-10-28
IL235526B1 (en) 2023-04-01
IL235526B2 (en) 2023-08-01
US20230277617A1 (en) 2023-09-07

Similar Documents

Publication Publication Date Title
MX2019012877A (es) Prevencion, interrupcion y tratamiento de biopeliculas con lisina de bacteriofago.
MX2019009132A (es) Composiciones bacterianas sinergicas y sus metodos de produccion y usos.
MY188541A (en) Besifloxacin for the treatment of resistant acne
PH12016502092A1 (en) Antimicrobial compounds and methods of making and using the same
PH12013502135A1 (en) Antimicrobial compounds and methods of making and using the same
GB201013307D0 (en) Anti-microbial metal organic framework
MX2018001075A (es) Agentes terapeuticos y profilacticos antibacterianos.
IN2014MN02437A (enExample)
EP3903823A3 (en) Antimicrobial peptides and methods of use thereof
TR201813877T4 (tr) Spi̇nal müsküler atrofi̇ni̇n tedavi̇ edi̇lmesi̇ne yöneli̇k bi̇leşi̇kler.
MX2012010671A (es) Compuestos antiinfecciosos.
PH12016501577B1 (en) Monobactam organic compounds for the treatment of bacterial infections
MX2015016319A (es) Terapia de combinacion que comprende oxazolidinona-quinolonas para uso en el tratamiento de infecciones bacterianas.
MX339000B (es) Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos.
MX2016009248A (es) Compuestos que contienen nitrogeno y su uso como agentes antibacterianos.
NZ728429A (en) Acinetobacter lysins
MX2017012545A (es) Compuestos heterociclicos y su uso en la prevencion o tratamiento de las infecciones bacterianas.
PH12015502375B1 (en) Antimicrobial compounds and methods of making and using the same
WO2015112980A3 (en) Dermaseptin-type and piscidin-type antimicrobial peptides
GB2548277A (en) Antibiofilm compositions
WO2016004513A8 (en) Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods
PH12017500338B1 (en) Anti-diarrhea formulation which avoids antimicrobial resistance
CA2972653C (en) ANTIBACTERIAL COMPOUNDS, ANTISENSE, AND PROCESSES
EP4241771A3 (en) Methods and compositions for treating sepsis
MY165011A (en) Antimicrobial compounds and methods of making and using the same

Legal Events

Date Code Title Description
FG Grant or registration