MX368855B - Compuestos de flavonoides novedosos y sus usos. - Google Patents
Compuestos de flavonoides novedosos y sus usos.Info
- Publication number
- MX368855B MX368855B MX2015004578A MX2015004578A MX368855B MX 368855 B MX368855 B MX 368855B MX 2015004578 A MX2015004578 A MX 2015004578A MX 2015004578 A MX2015004578 A MX 2015004578A MX 368855 B MX368855 B MX 368855B
- Authority
- MX
- Mexico
- Prior art keywords
- flavonoid compounds
- novel flavonoid
- treatment
- compounds
- formula
- Prior art date
Links
- 229930003935 flavonoid Natural products 0.000 title 1
- -1 flavonoid compounds Chemical class 0.000 title 1
- 235000017173 flavonoids Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 230000017074 necrotic cell death Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/07—Benzo[b]pyran-4-ones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2012904444A AU2012904444A0 (en) | 2012-10-11 | Novel Flavonoid compounds and uses thereof | |
| PCT/AU2013/001175 WO2014056038A1 (en) | 2012-10-11 | 2013-10-11 | Novel flavonoid compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015004578A MX2015004578A (es) | 2016-03-04 |
| MX368855B true MX368855B (es) | 2019-10-18 |
Family
ID=50476785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015004578A MX368855B (es) | 2012-10-11 | 2013-10-11 | Compuestos de flavonoides novedosos y sus usos. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10316053B2 (enExample) |
| EP (1) | EP2906578B8 (enExample) |
| JP (2) | JP6567419B2 (enExample) |
| KR (1) | KR102169002B1 (enExample) |
| CN (2) | CN104955831A (enExample) |
| AU (1) | AU2013330222B2 (enExample) |
| BR (1) | BR112015008156A2 (enExample) |
| CA (1) | CA2887488C (enExample) |
| DK (1) | DK2906578T3 (enExample) |
| ES (1) | ES2730926T3 (enExample) |
| MX (1) | MX368855B (enExample) |
| NZ (1) | NZ707087A (enExample) |
| RU (1) | RU2647842C2 (enExample) |
| SG (1) | SG11201502758SA (enExample) |
| TR (1) | TR201908822T4 (enExample) |
| WO (1) | WO2014056038A1 (enExample) |
| ZA (1) | ZA201502703B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111233806A (zh) * | 2020-03-20 | 2020-06-05 | 武汉轻工大学 | 一种3,5,4＇-三乙酰氧基-7-羟基黄酮的制备方法 |
| CN112168976B (zh) * | 2020-10-15 | 2022-11-04 | 天津科技大学 | 一种黄酮衍生物前药及合成和作为抗肿瘤药物的应用 |
| CN115504970B (zh) * | 2022-10-18 | 2023-04-18 | 黑龙江中医药大学 | 一种用于治疗心肌缺血的黄酮类衍生物及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06161129A (ja) * | 1992-11-25 | 1994-06-07 | Mita Ind Co Ltd | 電子写真感光体 |
| AU6174900A (en) * | 1999-07-08 | 2001-01-30 | Patrick T. Prendergast | Use of flavones, coumarins and related compounds to treat infections |
| EP1214308A2 (en) | 1999-09-23 | 2002-06-19 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Novel flavonoids |
| JP2003019867A (ja) * | 2001-04-19 | 2003-01-21 | Mitsubishi Chemicals Corp | 光記録媒体 |
| GB0125532D0 (en) | 2001-10-24 | 2001-12-12 | Burton Michael | Enzyme activity indicators |
| WO2006030322A2 (en) * | 2004-09-17 | 2006-03-23 | University Of Manitoba | Use of fla vone/fla vanone derivatives fn the treatment or prevention of respiratory conditions |
| US20060084615A1 (en) * | 2004-10-20 | 2006-04-20 | Chan Albert S | Puerarin derivatives and their medical uses |
| AU2006222556B2 (en) * | 2005-03-11 | 2011-09-29 | Armaron Bio Pty Ltd | Flavonoid compounds and uses thereof |
| JP2007230145A (ja) * | 2006-03-02 | 2007-09-13 | Mitsubishi Chemicals Corp | 光学記録媒体の記録層形成用色素、及びそれを用いた光学記録媒体、その光学記録媒体の記録方法 |
| WO2008011538A2 (en) * | 2006-07-19 | 2008-01-24 | The Salk Institute For Biological Studies | Methods of using flavonoids to enhance memory |
| US7863323B1 (en) * | 2006-10-27 | 2011-01-04 | The University Of Melbourne | Flavonols |
| DE102008012909A1 (de) | 2008-03-06 | 2009-09-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Flavonoidverbindungen für die Prophylaxe und Therapie ischämischer oder entzündlicher Herz- und Kreislauferkrankungen |
| CN101244057B (zh) * | 2008-03-11 | 2010-06-02 | 中国人民解放军第二军医大学 | 具有降血脂作用的3-取代氧基-3',4'-二甲氧基黄酮类化合物 |
| JP5424296B2 (ja) * | 2008-08-28 | 2014-02-26 | 静岡県公立大学法人 | フラボン誘導体の製造方法およびシアル酸転移酵素阻害剤 |
| EP2424541A2 (en) | 2009-04-27 | 2012-03-07 | Limerick BioPharma, Inc. | Phosphorylated and phosphonated pyrone analogs for therapeutic treatment |
| JP2012044944A (ja) * | 2010-08-27 | 2012-03-08 | Railway Technical Research Institute | トルエン検出方法 |
| DE102011104441A1 (de) * | 2011-06-16 | 2012-12-20 | Fujitsu Technology Solutions Intellectual Property Gmbh | Schaltnetzteil, Betriebsverfahren und Verwendung eines Schaltnetzteils in einem Computer |
| WO2013020184A1 (en) | 2011-08-11 | 2013-02-14 | Neuprotect Pty Ltd | Flavonoid compounds, and methods of use thereof |
| CN102631362B (zh) | 2012-01-19 | 2013-04-24 | 中国人民解放军第二军医大学 | 射干异黄酮类化合物在制备预防和治疗紫外线致皮肤损伤药物中的应用 |
| CN102617672B (zh) * | 2012-02-24 | 2014-03-12 | 大连大学 | 一种金花茶黄酮苷及其制备方法和用途 |
| CN102697768A (zh) | 2012-06-07 | 2012-10-03 | 中国人民解放军第二军医大学 | 一类木犀草素类似黄酮类化合物在制备抗肿瘤药物中的用途 |
| ES2810001T3 (es) * | 2012-10-02 | 2021-03-08 | Sphingotec Gmbh | Un método para diagnosticar o monitorizar la función renal |
-
2013
- 2013-10-11 EP EP13846070.4A patent/EP2906578B8/en not_active Not-in-force
- 2013-10-11 TR TR2019/08822T patent/TR201908822T4/tr unknown
- 2013-10-11 RU RU2015117641A patent/RU2647842C2/ru active
- 2013-10-11 US US14/435,164 patent/US10316053B2/en not_active Expired - Fee Related
- 2013-10-11 CA CA2887488A patent/CA2887488C/en not_active Expired - Fee Related
- 2013-10-11 DK DK13846070.4T patent/DK2906578T3/da active
- 2013-10-11 AU AU2013330222A patent/AU2013330222B2/en not_active Ceased
- 2013-10-11 ES ES13846070T patent/ES2730926T3/es active Active
- 2013-10-11 MX MX2015004578A patent/MX368855B/es active IP Right Grant
- 2013-10-11 NZ NZ707087A patent/NZ707087A/en not_active IP Right Cessation
- 2013-10-11 KR KR1020157012173A patent/KR102169002B1/ko not_active Expired - Fee Related
- 2013-10-11 WO PCT/AU2013/001175 patent/WO2014056038A1/en not_active Ceased
- 2013-10-11 BR BR112015008156A patent/BR112015008156A2/pt not_active Application Discontinuation
- 2013-10-11 JP JP2015535936A patent/JP6567419B2/ja not_active Expired - Fee Related
- 2013-10-11 CN CN201380058798.9A patent/CN104955831A/zh active Pending
- 2013-10-11 SG SG11201502758SA patent/SG11201502758SA/en unknown
- 2013-10-11 CN CN201711032323.9A patent/CN107759553A/zh active Pending
-
2015
- 2015-04-21 ZA ZA2015/02703A patent/ZA201502703B/en unknown
-
2018
- 2018-06-27 JP JP2018121870A patent/JP2018184414A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150096376A (ko) | 2015-08-24 |
| CA2887488C (en) | 2020-07-14 |
| JP6567419B2 (ja) | 2019-08-28 |
| WO2014056038A1 (en) | 2014-04-17 |
| JP2015533128A (ja) | 2015-11-19 |
| CN104955831A (zh) | 2015-09-30 |
| EP2906578B8 (en) | 2019-06-26 |
| SG11201502758SA (en) | 2015-05-28 |
| RU2647842C2 (ru) | 2018-03-21 |
| CN107759553A (zh) | 2018-03-06 |
| CA2887488A1 (en) | 2014-04-17 |
| ES2730926T3 (es) | 2019-11-13 |
| AU2013330222A1 (en) | 2015-05-21 |
| BR112015008156A2 (pt) | 2017-07-04 |
| EP2906578A4 (en) | 2016-03-23 |
| EP2906578A1 (en) | 2015-08-19 |
| NZ707087A (en) | 2016-04-29 |
| AU2013330222B2 (en) | 2016-05-12 |
| ZA201502703B (en) | 2016-11-30 |
| JP2018184414A (ja) | 2018-11-22 |
| KR102169002B1 (ko) | 2020-10-23 |
| TR201908822T4 (tr) | 2019-07-22 |
| EP2906578B1 (en) | 2019-05-08 |
| MX2015004578A (es) | 2016-03-04 |
| US20150259373A1 (en) | 2015-09-17 |
| DK2906578T3 (da) | 2019-07-15 |
| US10316053B2 (en) | 2019-06-11 |
| RU2015117641A (ru) | 2016-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |