MX366655B - Polímero adecuado para su uso en cultivo celular. - Google Patents

Polímero adecuado para su uso en cultivo celular.

Info

Publication number
MX366655B
MX366655B MX2016000612A MX2016000612A MX366655B MX 366655 B MX366655 B MX 366655B MX 2016000612 A MX2016000612 A MX 2016000612A MX 2016000612 A MX2016000612 A MX 2016000612A MX 366655 B MX366655 B MX 366655B
Authority
MX
Mexico
Prior art keywords
coupling
group
comonomer
oligo
azide
Prior art date
Application number
MX2016000612A
Other languages
English (en)
Other versions
MX2016000612A (es
Inventor
Edward Rowan Alan
Johannes Geutjes Petrus
F J Feitz Wouter
Oosterwijk Egbert
Hillet EKSTEEN AKEROYD Zaskia
Wilson Christopher
Original Assignee
Stichting Katholieke Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP13003621.3A external-priority patent/EP2826493A1/en
Application filed by Stichting Katholieke Univ filed Critical Stichting Katholieke Univ
Publication of MX2016000612A publication Critical patent/MX2016000612A/es
Publication of MX366655B publication Critical patent/MX366655B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
    • C08G65/325—Polymers modified by chemical after-treatment with inorganic compounds containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/3332—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carboxamide group
    • C08G65/33324—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carboxamide group acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/40—Polyamides containing oxygen in the form of ether groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C12N5/0691—Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Peptides Or Proteins (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

La presente invención se refiere a un procedimiento para preparar un copoliisocianopéptido funcionalizado con oligo (alquilenglicol), comprendiendo el procedimiento las etapas de: i) copolimerizar - un primer comonómero de un isocianopéptido funcionalizado con oligo (alquilenglicol) injertado con un grupo enlazante y - un segundo monómero de un isocianopéptido funcionalizado con oligo (alquilenglicol) sin injertar, en donde la proporción molar entre el primer comonómero y el segundo comonómero esde 1:500 y 1:30 y ii) añadir un reactante de una unidad espaciadora y un factor de adhesión celular al copolímero obtenido mediante la etapa i), en donde la unidad espaciadora se representa con la fórmula general A-L-B, en donde el grupo enlazante y el grupo A se eligen de modo que reaccionen y formen un primer acoplamiento y el factor de adhesión celular y el grupo B se eligen de modo que reaccionen y formen un segundo acoplamiento, en donde el primer acoplamiento y el segundo acoplamiento se seleccionan independientemente del grupo que consiste en acoplamiento alquino-azida, acoplamiento dibenzociclooctino-azida, acoplamientos de azida basada en oxanorbornad ieno, acoplamiento vinilsu Ifona-tiol, acoplamiento maleimida-tiol, acoplamiento metacrilato de metilo-tiol, acoplamiento de éter, acoplamiento de tioéter, acoplamiento biotina-estrepavidina, amina-ácido carboxílico resultante en enlaces de amidas, acoplamiento alcohol-ácido carboxílico resultante en enlaces de ésteres y acoplamiento de éster de NHS (éster de N-hidroxisuccinimida)-amina y en donde el grupo L es un segmento de cadena lineal que tiene 10-60 enlaces entre átomos seleccionados de C, N, O y S en la cadena principal.
MX2016000612A 2013-07-18 2014-07-16 Polímero adecuado para su uso en cultivo celular. MX366655B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13003621.3A EP2826493A1 (en) 2013-07-18 2013-07-18 Polymer suitable for use in cell culture
EP14153952 2014-02-05
PCT/EP2014/065233 WO2015007771A1 (en) 2013-07-18 2014-07-16 Polymer suitable for use in cell culture

Publications (2)

Publication Number Publication Date
MX2016000612A MX2016000612A (es) 2016-09-16
MX366655B true MX366655B (es) 2019-07-17

Family

ID=51211754

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000612A MX366655B (es) 2013-07-18 2014-07-16 Polímero adecuado para su uso en cultivo celular.

Country Status (10)

Country Link
US (1) US10266809B2 (es)
EP (1) EP3021872B1 (es)
JP (1) JP6347833B2 (es)
KR (1) KR102243783B1 (es)
CN (1) CN105611946B (es)
AU (1) AU2014292097B2 (es)
CA (1) CA2918408C (es)
ES (1) ES2637724T3 (es)
MX (1) MX366655B (es)
WO (1) WO2015007771A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3079668A1 (en) 2013-12-09 2016-10-19 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
EP3329945A1 (en) 2016-12-05 2018-06-06 Stichting Katholieke Universiteit Biomimetic networks comprising polyisocyanopeptide hydrogels
EP3395861A1 (en) 2017-04-24 2018-10-31 Stichting Katholieke Universiteit Biomimetic double network hydrogels
DE102018214534A1 (de) 2018-08-28 2020-03-05 Tesa Se Klebeband insbesondere für ölige Oberflächen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1103681A (en) 1966-01-28 1968-02-21 Geigy Uk Ltd Chemical compositions
JP5132936B2 (ja) * 2003-10-20 2013-01-30 カタリーナ・フィリッピーナ・ヤンセン 電子流発生用懸濁液並びに該懸濁液の使用及び製法
WO2010064251A1 (en) 2008-12-04 2010-06-10 Technion Research & Development Foundation Ltd Hydrogel sponges, methods of producing them and uses thereof
US20100215731A1 (en) 2009-02-20 2010-08-26 Maastricht University Method for improving cartilage repair and/or preventing cartilage degeneration in a joint
EP2287221A1 (en) * 2009-07-16 2011-02-23 Stichting Katholieke Universiteit meer in het bijzonder Radboud Universiteit Nijmegen Method for the preparation of high molecular weight oligo(alkylene glycol) functionalized polyisocyanopeptides
CN103153927B (zh) 2010-04-27 2017-02-15 西纳福克斯股份有限公司 稠合的环辛炔化合物及其在无金属点击反应中的应用
EP2404618A1 (en) * 2010-07-07 2012-01-11 Stichting Katholieke Universiteit meer in het bijzonder Radboud Universiteit Nijmegen Immunomodulatory protein constructs with a helical polymeric backbone.
WO2012158235A2 (en) * 2011-03-17 2012-11-22 Corning Incorporated Synthetic coating for cell culture

Also Published As

Publication number Publication date
KR102243783B1 (ko) 2021-04-23
CN105611946A (zh) 2016-05-25
US20160137977A1 (en) 2016-05-19
CN105611946B (zh) 2019-07-16
WO2015007771A1 (en) 2015-01-22
CA2918408A1 (en) 2015-01-22
KR20160034350A (ko) 2016-03-29
JP6347833B2 (ja) 2018-06-27
AU2014292097B2 (en) 2017-12-07
CA2918408C (en) 2021-04-20
ES2637724T3 (es) 2017-10-16
US10266809B2 (en) 2019-04-23
AU2014292097A1 (en) 2016-02-11
MX2016000612A (es) 2016-09-16
EP3021872A1 (en) 2016-05-25
EP3021872B1 (en) 2017-05-17
JP2016525106A (ja) 2016-08-22

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