MX363658B - N-(4-(azaindazol-6-il)-fenil)-sulfonamidas y su uso como productos farmacéuticos. - Google Patents
N-(4-(azaindazol-6-il)-fenil)-sulfonamidas y su uso como productos farmacéuticos.Info
- Publication number
- MX363658B MX363658B MX2015011353A MX2015011353A MX363658B MX 363658 B MX363658 B MX 363658B MX 2015011353 A MX2015011353 A MX 2015011353A MX 2015011353 A MX2015011353 A MX 2015011353A MX 363658 B MX363658 B MX 363658B
- Authority
- MX
- Mexico
- Prior art keywords
- azaindazol
- sulfonamides
- pharmaceuticals
- phenyl
- sgk
- Prior art date
Links
- SACLMPDSEYTADK-UHFFFAOYSA-N N1N=NC2=CC=C(C=C12)C1=CC=C(C=C1)NS(=O)=O Chemical class N1N=NC2=CC=C(C=C12)C1=CC=C(C=C1)NS(=O)=O SACLMPDSEYTADK-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 108010022404 serum-glucocorticoid regulated kinase Proteins 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 101000864800 Homo sapiens Serine/threonine-protein kinase Sgk1 Proteins 0.000 abstract 1
- 208000012659 Joint disease Diseases 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 102100030070 Serine/threonine-protein kinase Sgk1 Human genes 0.000 abstract 1
- 101150082971 Sgk1 gene Proteins 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención se refiere a N-(4-(azaindazol-6-il)-fenil)-s ulfonamidas de fórmula I, (ver Fórmula) en la que Ar, n, X, Z, R1, R2 y R3 tienen los significados indicados en las reivindicaciones. Los compuestos de fórmula I son valiosos compuestos farmacológicamente activos que modulan la actividad de proteína quinasa, específicamente la actividad de quinasa regulada por suero y glucocorticoides (SGK), en particular de la isoforma 1 de la quinasa regulada por suero y glucocorticoides (SGK-1, SGK1), y son adecuados para el tratamiento de enfermedades en las que la actividad de SGK es inapropiada, por ejemplo trastornos degenerativos de las articulaciones o procesos inflamatorios tales como osteoartritis o reumatismo. La invención se refiere además a procesos para la preparación de los compuestos de fórmula I, a su uso como productos farmacéuticos, y a composiciones farmacéuticas que comprenden los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305283 | 2013-03-13 | ||
| PCT/EP2014/054770 WO2014140065A1 (en) | 2013-03-13 | 2014-03-12 | N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015011353A MX2015011353A (es) | 2015-12-16 |
| MX363658B true MX363658B (es) | 2019-03-28 |
Family
ID=48040124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015011353A MX363658B (es) | 2013-03-13 | 2014-03-12 | N-(4-(azaindazol-6-il)-fenil)-sulfonamidas y su uso como productos farmacéuticos. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9718825B2 (es) |
| EP (1) | EP2970259B1 (es) |
| JP (1) | JP6404241B2 (es) |
| KR (2) | KR102219160B1 (es) |
| CN (1) | CN105189502B (es) |
| AR (1) | AR095279A1 (es) |
| AU (1) | AU2014230805B2 (es) |
| BR (1) | BR112015020287B1 (es) |
| CA (2) | CA3111517A1 (es) |
| CY (1) | CY1119151T1 (es) |
| DK (1) | DK2970259T3 (es) |
| ES (1) | ES2618213T3 (es) |
| HR (1) | HRP20170337T1 (es) |
| HU (1) | HUE031540T2 (es) |
| IL (1) | IL240178A (es) |
| LT (1) | LT2970259T (es) |
| MX (1) | MX363658B (es) |
| PL (1) | PL2970259T3 (es) |
| PT (1) | PT2970259T (es) |
| RU (1) | RU2671864C2 (es) |
| SG (1) | SG11201506093SA (es) |
| SI (1) | SI2970259T1 (es) |
| TW (1) | TWI629275B (es) |
| WO (1) | WO2014140065A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2992945A1 (en) | 2015-07-17 | 2017-01-26 | Memorial Sloan-Kettering Cancer Center | Combination therapy using pdk1 and pi3k inhibitors |
| TWI651308B (zh) * | 2016-09-23 | 2019-02-21 | 瑞士商諾華公司 | 用於肌腱及／或韌帶傷害之吲唑化合物 |
| JOP20190053A1 (ar) | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
| KR102678781B1 (ko) * | 2016-12-07 | 2024-06-27 | 오리모스 테라퓨틱스 씨오., 엘티디. | Sgk 활성을 조절하기 위한 화합물 및 약학 조성물 및 이의 방법 |
| TWI782056B (zh) | 2017-07-14 | 2022-11-01 | 日商鹽野義製藥股份有限公司 | 具有ｍｇａｔ２抑制活性的縮合環衍生物 |
| BR112020002265A2 (pt) | 2017-08-01 | 2020-07-28 | Theravance Biopharma R&D Ip, Llc | compostos pirazólicos e triazólicos bicíclicos como inibidores de jak quiinase |
| WO2020060268A1 (ko) | 2018-09-20 | 2020-03-26 | 한미약품 주식회사 | 상피세포 성장인자 수용체 돌연변이 저해 효과를 갖는 신규 융합 피리미딘 골격 설폰아마이드 유도체 |
| WO2020154350A1 (en) | 2019-01-23 | 2020-07-30 | Theravance Biopharma R&D Ip, Llc | Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors |
| WO2020178316A1 (en) * | 2019-03-05 | 2020-09-10 | Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. S.P.A. | 5- or 7-azaindazoles as beta-lactamase inhibitors |
| US20220388964A1 (en) * | 2019-04-12 | 2022-12-08 | Hibercell, Inc. | (aza)indazolyl-aryl sulfonamide and related compounds and their use in treating medical conditions |
| CN110379468B (zh) * | 2019-07-17 | 2022-08-23 | 成都火石创造科技有限公司 | 一种改进的化学分子式切分方法 |
| CA3172186A1 (en) * | 2021-01-13 | 2022-07-21 | Marc Vidal | Pyrazolo[3,4-d]pyrimidin-6-yl-sulfonamide derivatives for the inhibition of sgk-1 |
| EP4147700A1 (en) | 2021-09-08 | 2023-03-15 | LQT Therapeutics Inc. | N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides for use in the treatment of sickle cell disease |
| WO2024011316A1 (en) * | 2022-07-12 | 2024-01-18 | Thryv Therapeutics Inc. | Salts of n-[4-(4-[[2-(dimethylamino)ethyl]amino]-3-methyl-1h-pyrazolo[3,4-d]pyrimidin-6-yl)-2-fluorophenyl]-2,5-difluorobenzenesulfonamide and crystalline forms thereof |
| WO2024015055A1 (en) * | 2022-07-13 | 2024-01-18 | Thryv Therapeutics Inc. | Pyrazolo[3,4-d]pyrimidin-6-yl-sulfonamide derivatives for the inhibition of sgk-1 and treatment of cancer |
| WO2024173323A1 (en) * | 2023-02-14 | 2024-08-22 | Bristol-Myers Squibb Company | Amino-substituted pyrrolotriazine derivatives as inhibitors of sgk1 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2824121A (en) | 1954-11-04 | 1958-02-18 | Kay Fries Chemicals Inc | Process for preparation of oxy alkylidene compounds |
| US6921763B2 (en) * | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| AU2002341920A1 (en) * | 2001-10-02 | 2003-04-14 | Smithkline Beecham Corporation | Chemical compounds |
| US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| DE102004059781A1 (de) | 2004-12-10 | 2006-06-22 | Sanofi-Aventis Deutschland Gmbh | Verwendung der Serum-/Glucocorticoid regulierten Kinase |
| PE20061119A1 (es) * | 2005-01-19 | 2006-11-27 | Aventis Pharma Sa | PIRAZOLO PIRIDINAS SUSTITUIDAS COMO INHIBIDORES DE CINASAS FAK, KDR Y Tie |
| FR2889526B1 (fr) * | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
| GB0606804D0 (en) * | 2006-04-04 | 2006-05-17 | Novartis Ag | Organic Compounds |
| CN101516888A (zh) * | 2006-09-28 | 2009-08-26 | 诺瓦提斯公司 | 吡唑并[1,5-a]嘧啶衍生物及其治疗用途 |
| DE102007002717A1 (de) * | 2007-01-18 | 2008-07-24 | Merck Patent Gmbh | Heterocyclische Indazolderivate |
| US20080234262A1 (en) * | 2007-03-21 | 2008-09-25 | Wyeth | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors |
| WO2010118367A2 (en) * | 2009-04-10 | 2010-10-14 | Progenics Pharmaceuticals, Inc. | Antiviral pyrimidines |
| US8846673B2 (en) * | 2009-08-11 | 2014-09-30 | Bristol-Myers Squibb Company | Azaindazoles as kinase inhibitors and use thereof |
| SG11201400551UA (en) * | 2011-09-19 | 2014-04-28 | Sanofi Sa | N-[4-(1h-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides and their use as pharmaceuticals |
| JP5827849B2 (ja) * | 2011-09-20 | 2015-12-02 | サノフイ | Ｎ−［４−（１Ｈ−ピラゾロ［３，４−ｂ］ピラジン−６−イル）−フェニル］−スルホンアミド及び薬剤としてのその使用 |
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2014
- 2014-03-11 TW TW103108302A patent/TWI629275B/zh active
- 2014-03-12 LT LTEP14711467.2T patent/LT2970259T/lt unknown
- 2014-03-12 EP EP14711467.2A patent/EP2970259B1/en active Active
- 2014-03-12 AU AU2014230805A patent/AU2014230805B2/en active Active
- 2014-03-12 HU HUE14711467A patent/HUE031540T2/en unknown
- 2014-03-12 CA CA3111517A patent/CA3111517A1/en not_active Abandoned
- 2014-03-12 BR BR112015020287-0A patent/BR112015020287B1/pt active IP Right Grant
- 2014-03-12 AR ARP140100892A patent/AR095279A1/es active IP Right Grant
- 2014-03-12 KR KR1020157028355A patent/KR102219160B1/ko active IP Right Grant
- 2014-03-12 PT PT147114672T patent/PT2970259T/pt unknown
- 2014-03-12 ES ES14711467.2T patent/ES2618213T3/es active Active
- 2014-03-12 KR KR1020217004644A patent/KR20210021127A/ko not_active Application Discontinuation
- 2014-03-12 SG SG11201506093SA patent/SG11201506093SA/en unknown
- 2014-03-12 SI SI201430164A patent/SI2970259T1/sl unknown
- 2014-03-12 PL PL14711467T patent/PL2970259T3/pl unknown
- 2014-03-12 CN CN201480026425.8A patent/CN105189502B/zh active Active
- 2014-03-12 MX MX2015011353A patent/MX363658B/es unknown
- 2014-03-12 DK DK14711467.2T patent/DK2970259T3/en active
- 2014-03-12 WO PCT/EP2014/054770 patent/WO2014140065A1/en active Application Filing
- 2014-03-12 US US14/775,620 patent/US9718825B2/en active Active
- 2014-03-12 CA CA2901534A patent/CA2901534C/en active Active
- 2014-03-12 RU RU2015143000A patent/RU2671864C2/ru active
- 2014-03-12 JP JP2015562105A patent/JP6404241B2/ja active Active
-
2015
- 2015-07-27 IL IL240178A patent/IL240178A/en active IP Right Grant
-
2017
- 2017-03-01 HR HRP20170337TT patent/HRP20170337T1/hr unknown
- 2017-03-20 CY CY20171100347T patent/CY1119151T1/el unknown
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