MX358201B - Vacuna novedosa shigella atenuada viva. - Google Patents
Vacuna novedosa shigella atenuada viva.Info
- Publication number
- MX358201B MX358201B MX2015002813A MX2015002813A MX358201B MX 358201 B MX358201 B MX 358201B MX 2015002813 A MX2015002813 A MX 2015002813A MX 2015002813 A MX2015002813 A MX 2015002813A MX 358201 B MX358201 B MX 358201B
- Authority
- MX
- Mexico
- Prior art keywords
- ipa
- shigella
- live attenuated
- plasmid
- strain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0283—Shigella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a una vacuna Shigella viva atenuada, que se basa en una cepa Shigella rugosa que carece de O-antígeno LPS que es no invasivo a través de una mutación del plásmido de invasión, específicamente para uso en la inmunoprofilaxis de un sujeto para prevenir enfermedades infecciosas, preferiblemente enfermedades entéricas y una cepa Shigella, que es una cepa S. flexneri 2a con una eliminación de los genes rfbF, ipaB y/o ipaC, así como un vector de plásmido recombinante basado en un plásmido de invasión Shigella mutado que comprende una secuencia nucleótida que codifica al menos un antígeno heterólogo, en donde el plásmido está mutado en al menos uno de los genes ipaB y/o ipaC.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12183347 | 2012-09-06 | ||
| PCT/EP2013/068365 WO2014037440A2 (en) | 2012-09-06 | 2013-09-05 | A novel live attenuated shigella vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015002813A MX2015002813A (es) | 2015-08-20 |
| MX358201B true MX358201B (es) | 2018-08-03 |
Family
ID=46826297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015002813A MX358201B (es) | 2012-09-06 | 2013-09-05 | Vacuna novedosa shigella atenuada viva. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9730991B2 (es) |
| EP (3) | EP3978013A3 (es) |
| JP (1) | JP6329544B2 (es) |
| KR (3) | KR20210018542A (es) |
| CN (1) | CN104797268B (es) |
| AU (1) | AU2013311670B2 (es) |
| BR (1) | BR112015004775A2 (es) |
| CA (1) | CA2883652C (es) |
| DK (1) | DK2879700T3 (es) |
| EA (1) | EA031812B1 (es) |
| ES (1) | ES2636897T3 (es) |
| IL (1) | IL237508B2 (es) |
| IN (1) | IN2015DN02367A (es) |
| MX (1) | MX358201B (es) |
| SG (1) | SG11201501697UA (es) |
| WO (1) | WO2014037440A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE045556T2 (hu) * | 2013-12-20 | 2020-01-28 | Basf Se | Eljárás egy kívánt fehérje elõállítására mikrobiális gazdaszervezetben |
| CN107683332A (zh) * | 2015-04-24 | 2018-02-09 | 国际疫苗研究所 | 用于治疗或预防志贺菌病的疫苗组合物 |
| CA3044572A1 (en) * | 2016-11-25 | 2018-05-31 | Glaxosmithkline Biologicals S.A. | Nomv-antigen conjugates and use thereof |
| BR112020020377A2 (pt) * | 2018-04-03 | 2021-01-19 | University Of Maryland, Baltimore | Vacina polivalente aprimorada para shigella-e. coli enterotoxigênica |
| CN108410790B (zh) * | 2018-05-24 | 2019-05-14 | 中国人民解放军军事科学院军事医学研究院 | ebgR基因敲除重组志贺氏菌的制备及应用 |
| WO2022078732A1 (en) | 2020-10-14 | 2022-04-21 | Eveliqure Biotechnologies Gmbh | High dose shigella vaccine preparation |
| MX2023007814A (es) * | 2020-12-29 | 2023-07-07 | Hipra Scient S L U | Composiciones inmunogenicas y vacunales contra la disenteria porcina. |
| CN114990042A (zh) * | 2022-06-17 | 2022-09-02 | 南昌大学 | 一种含有能表达痢疾志贺氏菌o抗原的脂多糖的沙门菌、制备方法及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877159A (en) * | 1995-05-03 | 1999-03-02 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same |
| US6136542A (en) * | 1998-05-13 | 2000-10-24 | Institut Pasteur | Method for screening for inhibitors and activators of type III secretion machinery in gram-negative bacteria |
| US6399074B1 (en) | 1998-07-24 | 2002-06-04 | Megan Health, Inc. | Live attenuated salmonella vaccines to control avian pathogens |
| US6713073B1 (en) * | 1998-07-24 | 2004-03-30 | Megan Health, Inc. | Method of vaccination of newly hatched poultry |
| WO2000018355A2 (en) * | 1998-09-30 | 2000-04-06 | Walter Reed Army Institute Of Research | Use of purified invaplex from gram negative bacteria as a vaccine |
| US7381557B2 (en) * | 2003-04-07 | 2008-06-03 | Tufts University | Compositions and methods for bacterial immunity and secretion of proteins |
| EP2546260B1 (en) * | 2004-05-24 | 2015-07-15 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Live, oral vaccine for protection against shigella dysenteriae serotype 1 |
| CA2563214A1 (en) * | 2006-10-12 | 2008-04-12 | Institut Pasteur | Shigella ipad protein and its use as a potential vaccine against shigella infection |
| US8709444B2 (en) * | 2009-05-14 | 2014-04-29 | Northwestern University | Live-attenuated compositions for bacterial infections |
| WO2011044499A2 (en) | 2009-10-09 | 2011-04-14 | South Dakota State University | Enterotoxigenic e. coli fusion protein vaccines |
-
2013
- 2013-09-05 SG SG11201501697UA patent/SG11201501697UA/en unknown
- 2013-09-05 MX MX2015002813A patent/MX358201B/es active IP Right Grant
- 2013-09-05 EP EP21194517.5A patent/EP3978013A3/en active Pending
- 2013-09-05 ES ES13762423.5T patent/ES2636897T3/es active Active
- 2013-09-05 IL IL237508A patent/IL237508B2/en unknown
- 2013-09-05 CA CA2883652A patent/CA2883652C/en active Active
- 2013-09-05 JP JP2015530384A patent/JP6329544B2/ja active Active
- 2013-09-05 CN CN201380053521.7A patent/CN104797268B/zh active Active
- 2013-09-05 KR KR1020217003772A patent/KR20210018542A/ko not_active Application Discontinuation
- 2013-09-05 WO PCT/EP2013/068365 patent/WO2014037440A2/en active Application Filing
- 2013-09-05 KR KR1020197027679A patent/KR20190110645A/ko active Application Filing
- 2013-09-05 EP EP13762423.5A patent/EP2879700B1/en active Active
- 2013-09-05 BR BR112015004775A patent/BR112015004775A2/pt not_active Application Discontinuation
- 2013-09-05 IN IN2367DEN2015 patent/IN2015DN02367A/en unknown
- 2013-09-05 AU AU2013311670A patent/AU2013311670B2/en active Active
- 2013-09-05 EP EP17174523.5A patent/EP3238741A1/en active Pending
- 2013-09-05 EA EA201500279A patent/EA031812B1/ru unknown
- 2013-09-05 DK DK13762423.5T patent/DK2879700T3/en active
- 2013-09-05 KR KR1020157006359A patent/KR102071743B1/ko active IP Right Grant
- 2013-09-05 US US14/426,123 patent/US9730991B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA201500279A1 (ru) | 2015-08-31 |
| SG11201501697UA (en) | 2015-04-29 |
| US9730991B2 (en) | 2017-08-15 |
| IL237508B (en) | 2022-12-01 |
| EP3978013A3 (en) | 2022-07-06 |
| EP2879700A2 (en) | 2015-06-10 |
| KR20190110645A (ko) | 2019-09-30 |
| CN104797268A (zh) | 2015-07-22 |
| KR102071743B1 (ko) | 2020-01-31 |
| EA031812B1 (ru) | 2019-02-28 |
| BR112015004775A2 (pt) | 2017-11-21 |
| CA2883652C (en) | 2020-04-14 |
| EP2879700B1 (en) | 2017-06-07 |
| US20150246107A1 (en) | 2015-09-03 |
| WO2014037440A2 (en) | 2014-03-13 |
| IL237508B2 (en) | 2023-04-01 |
| JP2015532655A (ja) | 2015-11-12 |
| KR20210018542A (ko) | 2021-02-17 |
| MX2015002813A (es) | 2015-08-20 |
| AU2013311670A1 (en) | 2015-03-05 |
| ES2636897T3 (es) | 2017-10-10 |
| AU2013311670B2 (en) | 2018-04-05 |
| CA2883652A1 (en) | 2014-03-13 |
| KR20150048771A (ko) | 2015-05-07 |
| EP3978013A2 (en) | 2022-04-06 |
| IL237508A0 (en) | 2015-04-30 |
| WO2014037440A3 (en) | 2014-10-02 |
| DK2879700T3 (en) | 2017-09-11 |
| JP6329544B2 (ja) | 2018-05-23 |
| CN104797268B (zh) | 2018-05-01 |
| EP3238741A1 (en) | 2017-11-01 |
| IN2015DN02367A (es) | 2015-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |