IN2015DN02367A - - Google Patents
Info
- Publication number
- IN2015DN02367A IN2015DN02367A IN2367DEN2015A IN2015DN02367A IN 2015DN02367 A IN2015DN02367 A IN 2015DN02367A IN 2367DEN2015 A IN2367DEN2015 A IN 2367DEN2015A IN 2015DN02367 A IN2015DN02367 A IN 2015DN02367A
- Authority
- IN
- India
- Prior art keywords
- ipa
- shigella
- plasmid
- strain
- genes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0283—Shigella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
A live attenuated Shigella vaccine, which is based on a rough Shigella strain lacking LPS O -antigen which is non- invasive through a mutation of the invasion plasmid , specifically for use in the immunoprophylaxis of a subject to prevent infectious diseases preferably enteral disease , and a Shigella strain, which is a S. flexneri 2a strain with a deletion of the rfb F, ipa B and/or ipa C genes , as well as a recombinant plasmid vector based on a mutated Shigella invasion plasmid comprising a nucleotide sequence encoding at least one heterologous antigen , wherein the plasmid is mutated in at least one of the ipa B and/or ipa C genes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12183347 | 2012-09-06 | ||
| PCT/EP2013/068365 WO2014037440A2 (en) | 2012-09-06 | 2013-09-05 | A novel live attenuated shigella vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN02367A true IN2015DN02367A (en) | 2015-09-04 |
Family
ID=46826297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2367DEN2015 IN2015DN02367A (en) | 2012-09-06 | 2013-09-05 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9730991B2 (en) |
| EP (3) | EP2879700B1 (en) |
| JP (1) | JP6329544B2 (en) |
| KR (3) | KR20190110645A (en) |
| CN (1) | CN104797268B (en) |
| AU (1) | AU2013311670B2 (en) |
| BR (1) | BR112015004775A2 (en) |
| CA (1) | CA2883652C (en) |
| DK (1) | DK2879700T3 (en) |
| EA (1) | EA031812B1 (en) |
| ES (1) | ES2636897T3 (en) |
| IL (1) | IL237508B2 (en) |
| IN (1) | IN2015DN02367A (en) |
| MX (1) | MX358201B (en) |
| SG (1) | SG11201501697UA (en) |
| WO (1) | WO2014037440A2 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3083965T3 (en) * | 2013-12-20 | 2019-10-14 | Basf Se | PROCEDURE FOR PREPARING A PROTEIN OF INTEREST IN A MICROBIAL HOST ORGANISM |
| WO2016171524A1 (en) * | 2015-04-24 | 2016-10-27 | 국제백신연구소 | Vaccine composition for treating or preventing dysentery |
| BE1025443B1 (en) * | 2016-11-25 | 2019-02-28 | Glaxosmithkline Biologicals Sa | NOMV-ANTIGEN CONJUGATES AND THEIR USE |
| JP2021519789A (en) * | 2018-04-03 | 2021-08-12 | ユニバーシティ オブ メリーランド，ボルチモア | Enhanced Shigella polyvalent-toxinogenic E. coli vaccine |
| CN108410790B (en) * | 2018-05-24 | 2019-05-14 | 中国人民解放军军事科学院军事医学研究院 | The preparation and application of ebgR gene knockout recombination Shigella |
| EP4243861A1 (en) | 2020-10-14 | 2023-09-20 | EveliQure Biotechnologies GmbH | High dose shigella vaccine preparation |
| US20240108708A1 (en) * | 2020-12-29 | 2024-04-04 | Hipra Scientific, S.L.U. | Immunogenic and vaccine compositions against swine dysentery |
| CN114990042A (en) * | 2022-06-17 | 2022-09-02 | 南昌大学 | Salmonella containing lipopolysaccharide capable of expressing shigella dysenteriae O antigen, preparation method and application thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877159A (en) * | 1995-05-03 | 1999-03-02 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same |
| US6136542A (en) * | 1998-05-13 | 2000-10-24 | Institut Pasteur | Method for screening for inhibitors and activators of type III secretion machinery in gram-negative bacteria |
| US6713073B1 (en) * | 1998-07-24 | 2004-03-30 | Megan Health, Inc. | Method of vaccination of newly hatched poultry |
| US6399074B1 (en) * | 1998-07-24 | 2002-06-04 | Megan Health, Inc. | Live attenuated salmonella vaccines to control avian pathogens |
| ATE274353T1 (en) * | 1998-09-30 | 2004-09-15 | Us Army | USE OF PURIFIED INVAPLEX AS A VACCINE FOR GRAM NEGATIVE BACTERIA |
| EP1756149B1 (en) * | 2004-05-24 | 2013-09-04 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Live, oral vaccine for protection against shigella dysenteriae serotype 1 |
| CA2563214A1 (en) * | 2006-10-12 | 2008-04-12 | Institut Pasteur | Shigella ipad protein and its use as a potential vaccine against shigella infection |
| WO2011044499A2 (en) * | 2009-10-09 | 2011-04-14 | South Dakota State University | Enterotoxigenic e. coli fusion protein vaccines |
-
2013
- 2013-09-05 SG SG11201501697UA patent/SG11201501697UA/en unknown
- 2013-09-05 BR BR112015004775A patent/BR112015004775A2/en not_active Application Discontinuation
- 2013-09-05 WO PCT/EP2013/068365 patent/WO2014037440A2/en active Application Filing
- 2013-09-05 EP EP13762423.5A patent/EP2879700B1/en active Active
- 2013-09-05 AU AU2013311670A patent/AU2013311670B2/en active Active
- 2013-09-05 EP EP21194517.5A patent/EP3978013A3/en active Pending
- 2013-09-05 CA CA2883652A patent/CA2883652C/en active Active
- 2013-09-05 CN CN201380053521.7A patent/CN104797268B/en active Active
- 2013-09-05 EA EA201500279A patent/EA031812B1/en unknown
- 2013-09-05 KR KR1020197027679A patent/KR20190110645A/en active Application Filing
- 2013-09-05 JP JP2015530384A patent/JP6329544B2/en active Active
- 2013-09-05 ES ES13762423.5T patent/ES2636897T3/en active Active
- 2013-09-05 US US14/426,123 patent/US9730991B2/en active Active
- 2013-09-05 EP EP17174523.5A patent/EP3238741A1/en active Pending
- 2013-09-05 IL IL237508A patent/IL237508B2/en unknown
- 2013-09-05 KR KR1020217003772A patent/KR20210018542A/en not_active Application Discontinuation
- 2013-09-05 MX MX2015002813A patent/MX358201B/en active IP Right Grant
- 2013-09-05 IN IN2367DEN2015 patent/IN2015DN02367A/en unknown
- 2013-09-05 KR KR1020157006359A patent/KR102071743B1/en active IP Right Grant
- 2013-09-05 DK DK13762423.5T patent/DK2879700T3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2879700B1 (en) | 2017-06-07 |
| EA031812B1 (en) | 2019-02-28 |
| EP3978013A3 (en) | 2022-07-06 |
| CN104797268A (en) | 2015-07-22 |
| IL237508A0 (en) | 2015-04-30 |
| AU2013311670A1 (en) | 2015-03-05 |
| JP6329544B2 (en) | 2018-05-23 |
| EA201500279A1 (en) | 2015-08-31 |
| IL237508B2 (en) | 2023-04-01 |
| CA2883652C (en) | 2020-04-14 |
| JP2015532655A (en) | 2015-11-12 |
| BR112015004775A2 (en) | 2017-11-21 |
| AU2013311670B2 (en) | 2018-04-05 |
| EP3238741A1 (en) | 2017-11-01 |
| KR20190110645A (en) | 2019-09-30 |
| KR20150048771A (en) | 2015-05-07 |
| DK2879700T3 (en) | 2017-09-11 |
| EP3978013A2 (en) | 2022-04-06 |
| CN104797268B (en) | 2018-05-01 |
| US9730991B2 (en) | 2017-08-15 |
| KR102071743B1 (en) | 2020-01-31 |
| ES2636897T3 (en) | 2017-10-10 |
| MX358201B (en) | 2018-08-03 |
| KR20210018542A (en) | 2021-02-17 |
| EP2879700A2 (en) | 2015-06-10 |
| SG11201501697UA (en) | 2015-04-29 |
| CA2883652A1 (en) | 2014-03-13 |
| WO2014037440A2 (en) | 2014-03-13 |
| MX2015002813A (en) | 2015-08-20 |
| US20150246107A1 (en) | 2015-09-03 |
| IL237508B (en) | 2022-12-01 |
| WO2014037440A3 (en) | 2014-10-02 |
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