MX348152B - Anticuerpo monoclonal humano con especificidad para el virus del dengue serotipo 1 proteina e y sus usos. - Google Patents

Anticuerpo monoclonal humano con especificidad para el virus del dengue serotipo 1 proteina e y sus usos.

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Publication number
MX348152B
MX348152B MX2013006710A MX2013006710A MX348152B MX 348152 B MX348152 B MX 348152B MX 2013006710 A MX2013006710 A MX 2013006710A MX 2013006710 A MX2013006710 A MX 2013006710A MX 348152 B MX348152 B MX 348152B
Authority
MX
Mexico
Prior art keywords
protein
antibody
specificity
monoclonal antibody
human monoclonal
Prior art date
Application number
MX2013006710A
Other languages
English (en)
Other versions
MX2013006710A (es
Inventor
Anthony Macary Paul
Ping Evelyn Teoh Ee
John Hanson Brendon
Wei Teo En
Pei Chiew Lim Angeline
Lee Mary Ng Mah
Mei Lok Shee
Eveliina Kukkaro Petra
Original Assignee
Nat Univ Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Univ Singapore filed Critical Nat Univ Singapore
Publication of MX2013006710A publication Critical patent/MX2013006710A/es
Publication of MX348152B publication Critical patent/MX348152B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un anticuerpo aislado o fragmento del mismo que se liga específicamente a la proteína de envoltura del virus Dengue serotipo 1 o fragmento del mismo, en donde el anticuerpo es un anticuerpo humano con actividad neutralizante que se liga a través de dos proteína E en un virus, en donde la unión a través de dos proteínas E comprende ligarse a DI y la bisagra entre DI y II en una proteína E y DIII de una proteína E vecina. El segundo uso del anticuerpo, el ácido nucleico que codifica al anticuerpo, un vector que comprende el ácido nucleico y la célula huésped.
MX2013006710A 2010-12-14 2011-12-14 Anticuerpo monoclonal humano con especificidad para el virus del dengue serotipo 1 proteina e y sus usos. MX348152B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42308510P 2010-12-14 2010-12-14
PCT/SG2011/000436 WO2012082073A1 (en) 2010-12-14 2011-12-14 Human monoclonal antibody with specificity for dengue virus serotype 1 e protein and uses thereof

Publications (2)

Publication Number Publication Date
MX2013006710A MX2013006710A (es) 2014-09-25
MX348152B true MX348152B (es) 2017-06-02

Family

ID=46244986

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006710A MX348152B (es) 2010-12-14 2011-12-14 Anticuerpo monoclonal humano con especificidad para el virus del dengue serotipo 1 proteina e y sus usos.

Country Status (28)

Country Link
US (2) US9376486B2 (es)
EP (1) EP2651975B1 (es)
JP (2) JP6483337B2 (es)
KR (2) KR101904232B1 (es)
CN (1) CN103534270B (es)
AU (2) AU2011341744B2 (es)
BR (1) BR112013015129B1 (es)
CA (1) CA2821268C (es)
CO (1) CO6801636A2 (es)
CY (1) CY1119854T1 (es)
DK (1) DK2651975T3 (es)
EA (1) EA201390874A1 (es)
ES (1) ES2644236T3 (es)
HR (1) HRP20171580T1 (es)
HU (1) HUE035609T2 (es)
IL (1) IL226957B (es)
LT (1) LT2651975T (es)
MX (1) MX348152B (es)
MY (2) MY166537A (es)
PH (2) PH12013501242B1 (es)
PL (1) PL2651975T3 (es)
PT (1) PT2651975T (es)
RS (1) RS56737B1 (es)
SG (2) SG10201510111PA (es)
SI (1) SI2651975T1 (es)
SM (1) SMT201700477T1 (es)
WO (1) WO2012082073A1 (es)
ZA (1) ZA201304459B (es)

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US9821050B2 (en) 2012-04-02 2017-11-21 The University Of North Carolina At Chapel Hill Chimeric dengue virus E glycoproteins comprising mutant domain I and domain II hinge regions
WO2014064707A1 (en) * 2012-10-26 2014-05-01 International Centre For Genetic Engineering And Biotechnology Pichia pastoris -expressed dengue virus like particles
ES2745431T3 (es) * 2013-06-26 2020-03-02 Univ North Carolina Chapel Hill Composiciones para vacunas contra el virus del dengue y su uso
CN106211773B (zh) 2014-02-11 2021-09-03 威特拉公司 用于登革病毒的抗体分子及其应用
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EP3494991A4 (en) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha COMPOSITION FOR THE PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES
SG10201607778XA (en) * 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
CN112119090B (zh) 2018-03-15 2023-01-13 中外制药株式会社 对寨卡病毒具有交叉反应性的抗登革热病毒抗体及使用方法
US10526398B2 (en) * 2018-06-12 2020-01-07 National Defense Medical Center Anti-dengue virus antibodies and applications thereof
US12161890B2 (en) 2018-08-07 2024-12-10 Cz Biohub Sf, Llc Antibodies against dengue virus and related methods
WO2021102363A1 (en) * 2019-11-20 2021-05-27 The University Of North Carolina At Chapel Hill Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development
WO2021127017A1 (en) * 2019-12-16 2021-06-24 La Jolla Institute For Immunology Combinations of flavivirus proteins, peptide sequences, epitopes, and methods and uses thereof
CN117157524A (zh) * 2020-10-07 2023-12-01 赛诺菲巴斯德有限公司 改良的诊断测试
WO2022161597A1 (en) * 2021-01-26 2022-08-04 Eth Zurich Method for rapid identification of cross-reactive and/or rare antibodies
WO2022162009A1 (en) 2021-01-26 2022-08-04 Eth Zurich Method for rapid identification of cross-reactive and/or rare antibodies

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Also Published As

Publication number Publication date
KR101781546B1 (ko) 2017-09-26
PT2651975T (pt) 2017-11-14
US20130259871A1 (en) 2013-10-03
ZA201304459B (en) 2019-11-27
CO6801636A2 (es) 2013-11-29
US20170029489A1 (en) 2017-02-02
JP2014502839A (ja) 2014-02-06
CN103534270B (zh) 2017-03-08
PH12017501075B1 (en) 2019-11-29
PL2651975T3 (pl) 2018-04-30
PH12013501242A1 (en) 2013-08-12
SMT201700477T1 (it) 2018-01-11
US10294293B2 (en) 2019-05-21
US9376486B2 (en) 2016-06-28
AU2016269515A1 (en) 2017-01-05
CY1119854T1 (el) 2018-06-27
DK2651975T3 (en) 2017-10-30
ES2644236T3 (es) 2017-11-28
IL226957B (en) 2020-03-31
SG10201510111PA (en) 2016-01-28
CA2821268A1 (en) 2012-06-21
EA201390874A1 (ru) 2013-12-30
KR101904232B1 (ko) 2018-10-05
JP6483337B2 (ja) 2019-03-13
SG191155A1 (en) 2013-07-31
MY166537A (en) 2018-07-10
EP2651975A1 (en) 2013-10-23
EP2651975B1 (en) 2017-08-09
CA2821268C (en) 2021-06-15
MX2013006710A (es) 2014-09-25
RS56737B1 (sr) 2018-03-30
JP2018046835A (ja) 2018-03-29
BR112013015129A2 (en) 2018-10-09
HUE035609T2 (hu) 2018-05-28
EP2651975A4 (en) 2014-05-21
WO2012082073A1 (en) 2012-06-21
KR20140019777A (ko) 2014-02-17
SI2651975T1 (en) 2018-03-30
MY201732A (en) 2024-03-14
AU2011341744B2 (en) 2016-09-08
KR20170110159A (ko) 2017-10-10
LT2651975T (lt) 2018-02-12
PH12013501242B1 (en) 2019-01-30
AU2011341744A1 (en) 2013-07-18
PH12017501075A1 (en) 2018-02-12
BR112013015129B1 (pt) 2022-11-16
CN103534270A (zh) 2014-01-22
HRP20171580T1 (hr) 2018-01-26

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