MX348074B - Procedimiento para preparar n-(5-cloro-2-isopropilbencil) ciclopropanamina. - Google Patents
Procedimiento para preparar n-(5-cloro-2-isopropilbencil) ciclopropanamina.Info
- Publication number
- MX348074B MX348074B MX2014012796A MX2014012796A MX348074B MX 348074 B MX348074 B MX 348074B MX 2014012796 A MX2014012796 A MX 2014012796A MX 2014012796 A MX2014012796 A MX 2014012796A MX 348074 B MX348074 B MX 348074B
- Authority
- MX
- Mexico
- Prior art keywords
- chloro
- isopropylbenzyl
- preparing
- cyclopropanam
- ine
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- NPQICEFTXKYSPD-UHFFFAOYSA-N n-[(5-chloro-2-propan-2-ylphenyl)methyl]cyclopropanamine Chemical compound CC(C)C1=CC=C(Cl)C=C1CNC1CC1 NPQICEFTXKYSPD-UHFFFAOYSA-N 0.000 title abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- CWMFOCDUMQCBQM-UHFFFAOYSA-N 1-(5-chloro-2-propan-2-ylphenyl)-n-cyclopropylmethanimine Chemical compound CC(C)C1=CC=C(Cl)C=C1C=NC1CC1 CWMFOCDUMQCBQM-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
- C07C209/26—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with hydrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
- C07C209/365—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst by reduction with preservation of halogen-atoms in compounds containing nitro groups and halogen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/37—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/20—Diazonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/02—Monocyclic aromatic halogenated hydrocarbons
- C07C25/06—Monochloro-benzene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S585/00—Chemistry of hydrocarbon compounds
- Y10S585/929—Special chemical considerations
- Y10S585/93—Process including synthesis of nonhydrocarbon intermediate
- Y10S585/931—Metal-, Si-, B-, or P-containing, e.g. Grignard
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12165663 | 2012-04-26 | ||
| PCT/EP2013/058570 WO2013160387A1 (en) | 2012-04-26 | 2013-04-25 | Process for preparing n-(5-chloro-2-isopropylbenzyl)cyclopropanamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014012796A MX2014012796A (es) | 2015-01-26 |
| MX348074B true MX348074B (es) | 2017-05-25 |
Family
ID=48325630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014012796A MX348074B (es) | 2012-04-26 | 2013-04-25 | Procedimiento para preparar n-(5-cloro-2-isopropilbencil) ciclopropanamina. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9440908B2 (OSRAM) |
| EP (1) | EP2841413B1 (OSRAM) |
| JP (2) | JP6255385B2 (OSRAM) |
| KR (2) | KR102085534B1 (OSRAM) |
| CN (2) | CN104245660A (OSRAM) |
| BR (1) | BR112014025981B1 (OSRAM) |
| DK (1) | DK2841413T3 (OSRAM) |
| ES (1) | ES2644600T3 (OSRAM) |
| IL (1) | IL235316A (OSRAM) |
| IN (1) | IN2014DN09934A (OSRAM) |
| MX (1) | MX348074B (OSRAM) |
| TW (3) | TWI589550B (OSRAM) |
| WO (1) | WO2013160387A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI562977B (en) * | 2010-11-05 | 2016-12-21 | Bayer Ip Gmbh | Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation |
| CN107805180A (zh) * | 2017-10-31 | 2018-03-16 | 天津北方食品有限公司 | 一种芳基重氮氯铜酸盐的制备方法 |
| KR102523652B1 (ko) | 2018-08-13 | 2023-04-18 | 대우조선해양 주식회사 | 자동화 된 무장 이송 및 장전 시스템 |
| CN110078587A (zh) * | 2019-05-16 | 2019-08-02 | 山东天一化学股份有限公司 | 一种间二溴苯的制备方法 |
| CN111138242A (zh) * | 2019-12-16 | 2020-05-12 | 上海雅本化学有限公司 | 2-溴-4-氯-1-异丙基苯的合成方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2816460C3 (de) * | 1978-04-15 | 1981-11-12 | Akzo Gmbh, 5600 Wuppertal | Verfahren zur Herstellung von asymmetrischen N-Phenyl-N`-substituierten p-Phenylendiaminen |
| DE3132690A1 (de) * | 1981-08-19 | 1983-03-17 | Bayer Ag, 5090 Leverkusen | (thio)-harnstoffe, ein verfahren zu ihrer herstellung, ihre verwendung als pflanzenschutzmittel und zwischenprodukte zu ihrer herstellung |
| US6242493B1 (en) * | 1998-03-13 | 2001-06-05 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| JP2005515206A (ja) * | 2001-12-12 | 2005-05-26 | ブリストル−マイヤーズ スクイブ カンパニー | Ｈｉｖインテグラーゼ・インヒビター |
| CA2553973A1 (en) * | 2004-01-21 | 2005-08-04 | Elan Pharmaceuticals, Inc. | Methods of treatment of amyloidosis using aspartyl-protease inihibitors |
| US20070179296A1 (en) * | 2005-12-28 | 2007-08-02 | Anacor Pharmaceuticals, Inc. | Process for manufacturing picolinate borinic esters |
| AU2006336504C9 (en) * | 2005-12-28 | 2015-05-14 | Vertex Pharmaceuticals Incorporated | 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis |
| US7671221B2 (en) * | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| US7910592B2 (en) | 2005-12-30 | 2011-03-22 | Merck Sharp & Dohme Corp. | CETP inhibitors |
| AR056882A1 (es) * | 2006-02-01 | 2007-10-31 | Bayer Cropscience Sa | Derivados del fungicida n- cicloalquil- bencil- amida |
| MX2009002921A (es) * | 2006-09-15 | 2009-04-01 | Schering Corp | Derivados de azetidinona para el tratamiento de trastornos del metabolismo lipidico. |
| EP2039684A1 (de) * | 2007-09-18 | 2009-03-25 | Bayer CropScience AG | Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung |
| WO2009055674A1 (en) | 2007-10-26 | 2009-04-30 | Targegen Inc. | Pyrrolopyrimidine alkynyl compounds and methods of making and using same |
| EP2251331A1 (en) | 2009-05-15 | 2010-11-17 | Bayer CropScience AG | Fungicide pyrazole carboxamides derivatives |
| AR076839A1 (es) * | 2009-05-15 | 2011-07-13 | Bayer Cropscience Ag | Derivados fungicidas de pirazol carboxamidas |
| CN101712603B (zh) * | 2009-12-04 | 2013-05-22 | 江苏工业学院 | 用格氏反应制备卤代甲基苯甲醛的方法 |
| CN102399241A (zh) * | 2010-09-09 | 2012-04-04 | 信诺美（北京）化工科技有限公司 | 一种芳香基磷酸二酯的合成方法 |
| TWI562977B (en) | 2010-11-05 | 2016-12-21 | Bayer Ip Gmbh | Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation |
| JP6240677B2 (ja) * | 2012-11-13 | 2017-11-29 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | カルボキサミド類を製造する方法 |
-
2013
- 2013-04-25 EP EP13720851.8A patent/EP2841413B1/en active Active
- 2013-04-25 TW TW102114876A patent/TWI589550B/zh active
- 2013-04-25 ES ES13720851.8T patent/ES2644600T3/es active Active
- 2013-04-25 MX MX2014012796A patent/MX348074B/es active IP Right Grant
- 2013-04-25 CN CN201380021718.2A patent/CN104245660A/zh active Pending
- 2013-04-25 TW TW106103700A patent/TWI630191B/zh active
- 2013-04-25 US US14/396,570 patent/US9440908B2/en active Active
- 2013-04-25 IN IN9934DEN2014 patent/IN2014DN09934A/en unknown
- 2013-04-25 JP JP2015507528A patent/JP6255385B2/ja active Active
- 2013-04-25 WO PCT/EP2013/058570 patent/WO2013160387A1/en not_active Ceased
- 2013-04-25 KR KR1020147033041A patent/KR102085534B1/ko active Active
- 2013-04-25 CN CN201710474547.9A patent/CN107056621A/zh active Pending
- 2013-04-25 TW TW107112472A patent/TWI726205B/zh active
- 2013-04-25 KR KR1020197030145A patent/KR102085535B1/ko active Active
- 2013-04-25 DK DK13720851.8T patent/DK2841413T3/en active
- 2013-04-25 BR BR112014025981-0A patent/BR112014025981B1/pt active IP Right Grant
-
2014
- 2014-10-23 IL IL235316A patent/IL235316A/en active IP Right Grant
-
2017
- 2017-09-29 JP JP2017191420A patent/JP6594389B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TWI726205B (zh) | 2021-05-01 |
| JP6255385B2 (ja) | 2017-12-27 |
| CN104245660A (zh) | 2014-12-24 |
| MX2014012796A (es) | 2015-01-26 |
| KR20150013601A (ko) | 2015-02-05 |
| KR102085535B1 (ko) | 2020-03-06 |
| US20150094492A1 (en) | 2015-04-02 |
| EP2841413B1 (en) | 2017-07-26 |
| IN2014DN09934A (OSRAM) | 2015-08-14 |
| DK2841413T3 (en) | 2017-10-30 |
| KR20190119190A (ko) | 2019-10-21 |
| JP2015519318A (ja) | 2015-07-09 |
| IL235316A (en) | 2017-09-28 |
| TW201720787A (zh) | 2017-06-16 |
| ES2644600T3 (es) | 2017-11-29 |
| US9440908B2 (en) | 2016-09-13 |
| KR102085534B1 (ko) | 2020-03-06 |
| JP6594389B2 (ja) | 2019-10-23 |
| TWI589550B (zh) | 2017-07-01 |
| TW201825444A (zh) | 2018-07-16 |
| BR112014025981B1 (pt) | 2020-10-20 |
| TW201348182A (zh) | 2013-12-01 |
| TWI630191B (zh) | 2018-07-21 |
| JP2018035176A (ja) | 2018-03-08 |
| EP2841413A1 (en) | 2015-03-04 |
| CN107056621A (zh) | 2017-08-18 |
| BR112014025981A2 (pt) | 2017-06-27 |
| WO2013160387A1 (en) | 2013-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |