MX3464E - Procedimiento para la preparacion de 4[2-cloro (ometiltio) pirid-3-il]-3,5-dicarbetoxi-2,6-dimetil-1,4-dihidropiridina - Google Patents

Procedimiento para la preparacion de 4[2-cloro (ometiltio) pirid-3-il]-3,5-dicarbetoxi-2,6-dimetil-1,4-dihidropiridina

Info

Publication number
MX3464E
MX3464E MX002128U MX212876U MX3464E MX 3464 E MX3464 E MX 3464E MX 002128 U MX002128 U MX 002128U MX 212876 U MX212876 U MX 212876U MX 3464 E MX3464 E MX 3464E
Authority
MX
Mexico
Prior art keywords
preparation
formula
chlorine
ometiltio
dihidropiridina
Prior art date
Application number
MX002128U
Other languages
English (en)
Inventor
Jean-Marie Teulon
Bernard Scheweisguth
Jean-Claude Cognaco
Original Assignee
Hexachimie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB33501/75A external-priority patent/GB1511694A/en
Application filed by Hexachimie filed Critical Hexachimie
Publication of MX3464E publication Critical patent/MX3464E/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

La presente invención se refiere a un procedimiento para la preparación de 4-[2-cloro (o metiltio)-pirid-3-il]-3,5-dicarbetoxi-2,6 dimetil-1,4-dihidropiridinas de la fórmula: (ver gaceta) donde R1 está seleccionado entre los radicales metilo y etilo y X está seleccionado entre un átomo de cloro y el radical SCH3, cuyo procedimiento se caracteriza por hacer reaccionar un aldheido orto-sustituído de fórmula: (ver gaceta) con un acetilacetato de alquilo de fórmula CH3-CO-CH2-COOR1, donde X y R1 tienen el significado dado anteriormente, a reflujo en un medio amoniacal alcohólico o hidroalcohólico.
MX002128U 1975-08-12 1976-08-04 Procedimiento para la preparacion de 4[2-cloro (ometiltio) pirid-3-il]-3,5-dicarbetoxi-2,6-dimetil-1,4-dihidropiridina MX3464E (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB33501/75A GB1511694A (en) 1975-08-12 1975-08-12 Pyridine derivatives
GB4518875 1975-10-31

Publications (1)

Publication Number Publication Date
MX3464E true MX3464E (es) 1980-12-09

Family

ID=26261898

Family Applications (1)

Application Number Title Priority Date Filing Date
MX002128U MX3464E (es) 1975-08-12 1976-08-04 Procedimiento para la preparacion de 4[2-cloro (ometiltio) pirid-3-il]-3,5-dicarbetoxi-2,6-dimetil-1,4-dihidropiridina

Country Status (19)

Country Link
US (1) US4096270A (es)
JP (1) JPS5223081A (es)
AR (1) AR209672A1 (es)
AT (1) AT351025B (es)
AU (1) AU504839B2 (es)
CA (1) CA1079284A (es)
CH (1) CH612678A5 (es)
CS (1) CS194774B2 (es)
DD (1) DD126696A5 (es)
DE (1) DE2635916A1 (es)
DK (1) DK362676A (es)
ES (1) ES450582A1 (es)
FR (1) FR2320750A1 (es)
MX (1) MX3464E (es)
NL (1) NL7608989A (es)
NO (1) NO144457C (es)
PT (1) PT65456B (es)
SE (1) SE7608959L (es)
SU (1) SU1007556A3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH639659A5 (de) * 1978-12-18 1983-11-30 Sandoz Ag Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.
DE2738153A1 (de) * 1977-08-24 1979-03-08 Bayer Ag 2-pyridyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2949464A1 (de) * 1978-12-18 1980-06-26 Sandoz Ag Benzoxadiazole und benzothiadiazole, ihre herstellung und verwendung
US4497808A (en) * 1981-12-30 1985-02-05 Ciba-Geigy Corporation N-Oxide compounds useful in the treatment of cardiovascular ailments
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
US4771057A (en) * 1986-02-03 1988-09-13 University Of Alberta Reduced pyridyl derivatives with cardiovascular regulating properties
DE4236707A1 (de) * 1992-10-30 1994-05-05 Bayer Ag 4-Heterocyclyl substituierte Dihydropyridine
US6001857A (en) * 1992-10-30 1999-12-14 Bayer Aktiengesellschaft Heterocyclyl substituted dihydropyridines

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE1813436C3 (de) * 1968-12-07 1979-01-11 Bayer Ag, 5090 Leverkusen N-Substituierte 2,6-Dimethyl-l,4dihydropyridine
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
ZA7152B (en) * 1970-01-24 1971-10-27 Bayer Ag New pharmaceutically active 1,4-dihydropyridines
DE2005116C3 (de) * 1970-02-05 1980-02-14 Bayer Ag, 5090 Leverkusen Symmetrische 1,4-Dihydropyridin-3,5-dicarbonsäureester
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2210672C3 (de) * 1972-03-06 1980-03-20 Bayer Ag, 5090 Leverkusen N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
AR209672A1 (es) 1977-05-13
US4096270A (en) 1978-06-20
SU1007556A3 (ru) 1983-03-23
NO144457C (no) 1981-09-02
PT65456B (fr) 1978-02-10
AT351025B (de) 1979-07-10
CS194774B2 (en) 1979-12-31
ATA568776A (de) 1978-12-15
PT65456A (fr) 1976-09-01
NO762790L (es) 1977-02-15
AU504839B2 (en) 1979-11-01
FR2320750A1 (fr) 1977-03-11
JPS5223081A (en) 1977-02-21
SE7608959L (sv) 1977-02-13
CH612678A5 (es) 1979-08-15
DD126696A5 (es) 1977-08-03
ES450582A1 (es) 1977-11-16
DE2635916A1 (de) 1977-02-24
NL7608989A (nl) 1977-02-15
FR2320750B1 (es) 1979-09-28
DK362676A (da) 1977-02-13
AU1656976A (en) 1978-02-09
CA1079284A (en) 1980-06-10
JPS5422986B2 (es) 1979-08-10
NO144457B (no) 1981-05-25

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