GB1511694A - Pyridine derivatives - Google Patents

Pyridine derivatives

Info

Publication number
GB1511694A
GB1511694A GB33501/75A GB3350175A GB1511694A GB 1511694 A GB1511694 A GB 1511694A GB 33501/75 A GB33501/75 A GB 33501/75A GB 3350175 A GB3350175 A GB 3350175A GB 1511694 A GB1511694 A GB 1511694A
Authority
GB
United Kingdom
Prior art keywords
prepared
compounds
pyridine derivatives
pyridyldihydropyridines
methylthionicotinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33501/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hexachimie SA
Original Assignee
Hexachimie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hexachimie SA filed Critical Hexachimie SA
Priority to GB33501/75A priority Critical patent/GB1511694A/en
Priority to FR7622285A priority patent/FR2320750A1/en
Priority to AT568776A priority patent/AT351025B/en
Priority to MX002128U priority patent/MX3464E/en
Priority to AU16569/76A priority patent/AU504839B2/en
Priority to ZA764706A priority patent/ZA764706B/en
Priority to CH1001576A priority patent/CH612678A5/xx
Priority to US05/711,862 priority patent/US4096270A/en
Priority to CA258,591A priority patent/CA1079284A/en
Priority to AR264249A priority patent/AR209672A1/en
Priority to HU76HE00000718A priority patent/HU171450B/en
Priority to ES450582A priority patent/ES450582A1/en
Priority to PT65456A priority patent/PT65456B/en
Priority to DD194263A priority patent/DD126696A5/xx
Priority to DE19762635916 priority patent/DE2635916A1/en
Priority to JP51095887A priority patent/JPS5223081A/en
Priority to DK362676A priority patent/DK362676A/en
Priority to NO762790A priority patent/NO144457C/en
Priority to SE7608959A priority patent/SE7608959L/en
Priority to CS765241A priority patent/CS194774B2/en
Priority to SU762386167A priority patent/SU1007556A3/en
Priority to BE2055236A priority patent/BE845104A/en
Priority to NL7608989A priority patent/NL7608989A/en
Publication of GB1511694A publication Critical patent/GB1511694A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1511694 Pyridyldihydropyridines HEXACHIMIE 30 July 1976 [12 Aug 1975 31 Oct 1975] 33501/75 and 45188/75 Heading C2C Compounds of the general formula (X=Cl, MeS; R 1 =Me, Et) and their acid addition salts are prepared by reacting the corresponding nicotinaldehyde, alkyl acetoacetate and ammonia, optionally followed by salt formation. 2 - Methylthionicotinaldehyde is prepared by reducing methyl 2-methylthionicotinate with potassium borohydride-lithium chloride, and oxidizing the resulting 3-hydroxymethyl-2-methylthiopyridine with manganese dioxide. The above compounds are antihypertensive agents, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB33501/75A 1975-08-12 1975-08-12 Pyridine derivatives Expired GB1511694A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
GB33501/75A GB1511694A (en) 1975-08-12 1975-08-12 Pyridine derivatives
FR7622285A FR2320750A1 (en) 1975-08-12 1976-07-21 1,4-DIHYDRO PYRIDINES AND THEIR THERAPEUTIC APPLICATION
AT568776A AT351025B (en) 1975-08-12 1976-08-02 PROCESS FOR THE PRODUCTION OF NEW 1,4-DIHYDRO-PYRIDINES AND THEIR SALTS
MX002128U MX3464E (en) 1975-08-12 1976-08-04 PROCEDURE FOR THE PREPARATION OF 4 [2-CHLORINE (OMETILTIO) PIRID-3-IL] -3,5-DICARBETOXI-2,6-DIMETIL-1,4-DIHIDROPIRIDINA
AU16569/76A AU504839B2 (en) 1975-08-12 1976-08-04 Dihydro-1, 4-pyridines
ZA764706A ZA764706B (en) 1975-08-12 1976-08-04 Substituted 1,4-dihydropyridines and process for their preparation
CH1001576A CH612678A5 (en) 1975-08-12 1976-08-05
US05/711,862 US4096270A (en) 1975-08-12 1976-08-05 4-(2-Chloro- or methylthiopyrid-3-yl)-3,5-dicarbalkoxy-2,6-dimethyl-1,4-dihydropyridine
CA258,591A CA1079284A (en) 1975-08-12 1976-08-06 4-pyrid-3-yl-3,5-dicarboxy-2,6-dimethyl-1,4-dihydropyridine compounds
AR264249A AR209672A1 (en) 1975-08-12 1976-08-06 PROCEDURE FOR THE PREPARATION OF 4- (2-SUBSTITUTED-3-PYRIDYL) -, 3,5-DICARBOALCOXY-2, -DIMETHYL-1,4-DIHYDROPYRIDINES
HU76HE00000718A HU171450B (en) 1975-08-12 1976-08-09 Process for preparing derivatives of the 1,4-dihydro-pyridine
ES450582A ES450582A1 (en) 1975-08-12 1976-08-09 4-(2-Chloro- or methylthiopyrid-3-yl)-3,5-dicarbalkoxy-2,6-dimethyl-1,4-dihydropyridine
PT65456A PT65456B (en) 1975-08-12 1976-08-09 PROCESS FOR PREPARING DIHYRO-1,4-PYRIDINES USEFULLY AS ANTIHYPERTENESS AND ANTI-ANGOUS DRUGS
DD194263A DD126696A5 (en) 1975-08-12 1976-08-10
DE19762635916 DE2635916A1 (en) 1975-08-12 1976-08-10 DIHYDRO-1,4-PYRIDINE AND MEDICINAL PRODUCTS CONTAINING THESE
JP51095887A JPS5223081A (en) 1975-08-12 1976-08-11 1*44dihydropyridines and application to remedy
DK362676A DK362676A (en) 1975-08-12 1976-08-11 PROCEDURE FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINES
NO762790A NO144457C (en) 1975-08-12 1976-08-11 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE DIHYDRO-1,4-PYRIDINES
SE7608959A SE7608959L (en) 1975-08-12 1976-08-11 PROCEDURE FOR THE PREPARATION OF DIHYDRO-1,4-PYRIDINES
CS765241A CS194774B2 (en) 1975-08-12 1976-08-11 Process for preparing derivatives of 1,4-dihydropyridine suitable especially as antihypertensive and antianginar medicament
SU762386167A SU1007556A3 (en) 1975-08-12 1976-08-12 Method of producing 1,4-dehydropyridines
BE2055236A BE845104A (en) 1975-08-12 1976-08-12 1,4-DIHYDRO PYRIDINES AND THEIR THERAPEUTIC APPLICATION
NL7608989A NL7608989A (en) 1975-08-12 1976-08-12 DIHYDRO-1,4 PYRIDINE DERIVATIVES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB33501/75A GB1511694A (en) 1975-08-12 1975-08-12 Pyridine derivatives

Publications (1)

Publication Number Publication Date
GB1511694A true GB1511694A (en) 1978-05-24

Family

ID=10353785

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33501/75A Expired GB1511694A (en) 1975-08-12 1975-08-12 Pyridine derivatives

Country Status (4)

Country Link
BE (1) BE845104A (en)
GB (1) GB1511694A (en)
HU (1) HU171450B (en)
ZA (1) ZA764706B (en)

Also Published As

Publication number Publication date
ZA764706B (en) 1977-07-27
HU171450B (en) 1978-01-28
BE845104A (en) 1976-12-01

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee