MX346071B - Método para controlar el peso molecular del polisacárido de streptococcus pneumoniae utilizando dióxido de carbono. - Google Patents

Método para controlar el peso molecular del polisacárido de streptococcus pneumoniae utilizando dióxido de carbono.

Info

Publication number
MX346071B
MX346071B MX2011006431A MX2011006431A MX346071B MX 346071 B MX346071 B MX 346071B MX 2011006431 A MX2011006431 A MX 2011006431A MX 2011006431 A MX2011006431 A MX 2011006431A MX 346071 B MX346071 B MX 346071B
Authority
MX
Mexico
Prior art keywords
fermentation culture
streptococcus pneumoniae
molecular weight
repeat units
saccharide repeat
Prior art date
Application number
MX2011006431A
Other languages
English (en)
Other versions
MX2011006431A (es
Inventor
Heather Crinean Jean
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of MX2011006431A publication Critical patent/MX2011006431A/es
Publication of MX346071B publication Critical patent/MX346071B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Abstract

La presente invención se refiere a métodos mejorados para producir una solución que contiene polisacáridos capsulares de Streptococcus pneumoniae de elevado peso molecular aislados que tienen enlaces fosfodiéster entre unidades de repetición de sacárido. En ciertos métodos, se suministra CO2 a un cultivo de fermentación de células bacteriales de Streptococcus pneumoniae que producen serotipos de polisacárido capsular que contienen enlaces fosfodiéster entre unidades de repetición de sacárido. Los serotipos de Streptococcus pneumoniae ilustrativos que contienen un enlace fosfodiéster entre unidades de repetición de sacárido incluyen serotipos 6A, 6B, 19A, y 19F. El suministro de CO2 al cultivo de fermentación incluye agregar iones bicarbonato al cultivo de fermentación, agregar iones carbonato al cultivo de fermentación, agregar mezclas de iones bicarbonato y carbonato al cultivo de fermentación, y sobreponer el cultivo de fermentación con CO2.
MX2011006431A 2008-12-18 2009-12-17 Método para controlar el peso molecular del polisacárido de streptococcus pneumoniae utilizando dióxido de carbono. MX346071B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13857008P 2008-12-18 2008-12-18
PCT/US2009/068424 WO2010080484A1 (en) 2008-12-18 2009-12-17 Method for controlling streptococcus pneumoniae polysaccharide molecular weight using carbon

Publications (2)

Publication Number Publication Date
MX2011006431A MX2011006431A (es) 2011-07-19
MX346071B true MX346071B (es) 2017-03-02

Family

ID=41666441

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011006431A MX346071B (es) 2008-12-18 2009-12-17 Método para controlar el peso molecular del polisacárido de streptococcus pneumoniae utilizando dióxido de carbono.

Country Status (19)

Country Link
US (4) US20100160622A1 (es)
EP (1) EP2385981B1 (es)
JP (2) JP5789514B2 (es)
KR (1) KR101307703B1 (es)
CN (1) CN102257127B (es)
AU (1) AU2009335824B2 (es)
BR (1) BRPI0923165A8 (es)
CA (1) CA2743708C (es)
DK (1) DK2385981T3 (es)
ES (1) ES2749952T3 (es)
HK (1) HK1163737A1 (es)
HU (1) HUE046859T2 (es)
IL (1) IL213215A (es)
MX (1) MX346071B (es)
PL (1) PL2385981T3 (es)
PT (1) PT2385981T (es)
RU (1) RU2524436C2 (es)
SI (1) SI2385981T1 (es)
WO (1) WO2010080484A1 (es)

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US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
EP3576784A4 (en) 2017-01-31 2020-11-11 Merck Sharp & Dohme Corp. PROCESS FOR THE PRODUCTION OF POLYSACCHARIDE PROTEIN CONJUGATES
WO2018156491A1 (en) 2017-02-24 2018-08-30 Merck Sharp & Dohme Corp. Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates
EP3678653A4 (en) 2017-09-07 2021-05-26 Merck Sharp & Dohme Corp. ANTIPNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN POLYSACCHARIDE-CARRIER PROTEIN IMMUNOGENIC CONJUGATES
KR20200051005A (ko) 2017-09-07 2020-05-12 머크 샤프 앤드 돔 코포레이션 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도
CN108004160A (zh) * 2017-11-30 2018-05-08 成都欧林生物科技股份有限公司 含有中药材的菌种培养基的制备方法
CN107746825A (zh) * 2017-11-30 2018-03-02 成都欧林生物科技股份有限公司 利于肺炎链球菌快速增殖的培养基
CA3084436A1 (en) 2017-12-06 2019-07-18 Merck Sharp & Dohme Corp. Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
JP7397000B2 (ja) 2018-04-30 2023-12-12 メルク・シャープ・アンド・ドーム・エルエルシー 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法
WO2020117949A1 (en) * 2018-12-06 2020-06-11 Inventprise, Llc Bacterial growth on non-animal derived media
AU2019401535B2 (en) 2018-12-19 2023-12-14 Merck Sharp & Dohme Llc Compositions comprising Streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof

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Also Published As

Publication number Publication date
CN102257127B (zh) 2014-01-01
JP2015144614A (ja) 2015-08-13
BRPI0923165A2 (pt) 2016-02-10
RU2011124143A (ru) 2013-01-27
US20200323974A1 (en) 2020-10-15
BRPI0923165A8 (pt) 2017-09-12
US20100160622A1 (en) 2010-06-24
PT2385981T (pt) 2019-10-28
SI2385981T1 (sl) 2019-11-29
HUE046859T2 (hu) 2020-03-30
JP5789514B2 (ja) 2015-10-07
ES2749952T3 (es) 2020-03-24
JP2012512659A (ja) 2012-06-07
EP2385981B1 (en) 2019-09-04
WO2010080484A1 (en) 2010-07-15
CA2743708C (en) 2018-01-09
PL2385981T3 (pl) 2020-01-31
CN102257127A (zh) 2011-11-23
US20150376667A1 (en) 2015-12-31
RU2524436C2 (ru) 2014-07-27
IL213215A0 (en) 2011-07-31
MX2011006431A (es) 2011-07-19
US11376315B2 (en) 2022-07-05
JP6095715B2 (ja) 2017-03-15
KR101307703B1 (ko) 2013-09-11
EP2385981A1 (en) 2011-11-16
DK2385981T3 (da) 2019-10-21
US20170224802A1 (en) 2017-08-10
CA2743708A1 (en) 2010-07-15
KR20110091548A (ko) 2011-08-11
AU2009335824A1 (en) 2010-07-15
HK1163737A1 (en) 2012-09-14
IL213215A (en) 2017-08-31
AU2009335824B2 (en) 2013-07-04

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