MX345624B - Derivados 6-amido de 4,5a-epoximorfinanos para tratamiento de dolor. - Google Patents
Derivados 6-amido de 4,5a-epoximorfinanos para tratamiento de dolor.Info
- Publication number
- MX345624B MX345624B MX2013004280A MX2013004280A MX345624B MX 345624 B MX345624 B MX 345624B MX 2013004280 A MX2013004280 A MX 2013004280A MX 2013004280 A MX2013004280 A MX 2013004280A MX 345624 B MX345624 B MX 345624B
- Authority
- MX
- Mexico
- Prior art keywords
- epoxymorphinans
- pain
- treatment
- amido derivatives
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9486—Analgesics, e.g. opiates, aspirine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Compuestos de la fórmula en la cual R4 se elige de fenilo substituido, naftileno opcionalmente substituido, antraceno opcionalmente substituido y heterociclo aromático opcionalmente substituido, son útiles como analgésicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39448110P | 2010-10-19 | 2010-10-19 | |
PCT/US2011/056827 WO2012054566A2 (en) | 2010-10-19 | 2011-10-19 | 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013004280A MX2013004280A (es) | 2013-10-17 |
MX345624B true MX345624B (es) | 2017-02-08 |
Family
ID=45975852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013004280A MX345624B (es) | 2010-10-19 | 2011-10-19 | Derivados 6-amido de 4,5a-epoximorfinanos para tratamiento de dolor. |
Country Status (12)
Country | Link |
---|---|
US (3) | US20130289060A1 (es) |
EP (1) | EP2630150B1 (es) |
JP (1) | JP6013345B2 (es) |
KR (1) | KR101960107B1 (es) |
CN (1) | CN103261203B (es) |
AU (1) | AU2011317183B2 (es) |
BR (1) | BR112013009505B1 (es) |
CA (1) | CA2814795C (es) |
ES (1) | ES2632932T3 (es) |
IL (1) | IL225755B (es) |
MX (1) | MX345624B (es) |
WO (1) | WO2012054566A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6013345B2 (ja) | 2010-10-19 | 2016-10-25 | メモリアル スローン−ケタリング キャンサー センター | 痛み治療用の4,5a−エポキシモルフィナンの6−アミド誘導体 |
WO2015082932A1 (en) * | 2013-12-05 | 2015-06-11 | The University Of Bath | Novel opioid compounds and their uses |
US11046692B2 (en) | 2015-04-30 | 2021-06-29 | Memorial Sloan-Kettering Cancer Center | Mitragynine analogs and uses thereof |
EP3997092A4 (en) * | 2019-07-08 | 2023-09-06 | University of Health Sciences & Pharmacy in St. Louis | G-PROTEIN POLARIZED OPIOID RECEPTOR AGONISTS/ANALGESICS WITH REDUCED ARRESTIN RECRUITMENT |
CN111116395B (zh) * | 2019-12-27 | 2023-04-07 | 湖北工业大学 | 多碘代芳香酸类化合物及其在抗腺病毒7型中的应用 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU666702B2 (en) * | 1992-01-23 | 1996-02-22 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
CA2143318A1 (en) * | 1993-06-30 | 1995-01-12 | Hiroshi Nagase | Antitussive agents |
DE69414085T2 (de) * | 1993-07-19 | 1999-03-18 | Toray Industries, Inc., Tokio/Tokyo | Wirkstoff zum schutze von gehirnzellen |
AU686203B2 (en) * | 1993-07-23 | 1998-02-05 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
EP0829481A1 (en) * | 1996-09-16 | 1998-03-18 | Pfizer Inc. | Morphinan hydroxamic acid compounds |
CA2270955C (en) * | 1997-09-02 | 2007-08-07 | Toray Industries Inc. | Pharmaceutical composition containing morphinan derivative for treating drug dependence |
CA2383146C (en) * | 1999-08-24 | 2010-11-16 | Hiroshi Nagase | Therapeutic agent for neuropathic pain and neuropathic pain animal model |
CA2403252A1 (en) * | 2000-03-15 | 2001-09-20 | Wolfgang Sadee | Neutral antagonists and use thereof in treating drug abuse |
CA2442423C (en) * | 2001-03-30 | 2009-11-03 | Toray Industries, Inc. | Therapeutic drug for psychoneurotic disorders |
ES2623362T3 (es) * | 2004-05-28 | 2017-07-11 | Human Biomolecular Research Institute | Analgésicos metabólicamente estables y medicaciones para el dolor |
EP1762569A1 (en) * | 2005-09-12 | 2007-03-14 | Alcasynn Pharmaceuticals Gmbh | Novel 6-amino-morphinan derivatives, method of manufacturing them and their application as analgesics |
WO2007039058A2 (en) * | 2005-09-23 | 2007-04-12 | Dsm Ip Assets B.V. | Use of opioid receptor antagonists |
JP5176188B2 (ja) * | 2006-04-21 | 2013-04-03 | ディーエスエム アイピー アセッツ ビー.ブイ. | オピオイド受容体拮抗薬の使用 |
KR101477043B1 (ko) * | 2007-04-24 | 2014-12-29 | 도레이 카부시키가이샤 | 디스키네시아의 치료 또는 예방제 |
EP2151241B1 (en) * | 2007-04-26 | 2012-03-21 | Toray Industries, Inc. | Stable solid preparation comprising 4,5-epoxymorphinan derivative |
WO2009044883A1 (ja) * | 2007-10-05 | 2009-04-09 | Toray Industries, Inc. | モルヒナン誘導体またはその薬理学的に許容される酸付加塩を有効成分とする皮膚性状改善治療薬 |
US8778958B2 (en) * | 2008-07-10 | 2014-07-15 | John R. Cashman | Synthesis of metabolically stable agents for alcohol and drug abuse |
EP2356989B1 (en) * | 2008-10-24 | 2018-02-07 | Toray Industries, Inc. | Stable tablet containing 4,5-epoxymorphinan derivative |
EP2387577A4 (en) * | 2009-01-16 | 2012-10-17 | Univ Virginia Commonwealth | STRONG AND SELECTIVE NON-PEPTIDYL MU OPIOID RECEPTOR ANTAGONISTS |
WO2011020030A2 (en) * | 2009-08-13 | 2011-02-17 | The General Hospital Corporation | Methods and compositions to prevent addiction |
CA2787323C (en) * | 2010-01-29 | 2017-08-29 | Toray Industries, Inc. | Therapeutic or prophylactic agent for biliary tract diseases |
JP6013345B2 (ja) | 2010-10-19 | 2016-10-25 | メモリアル スローン−ケタリング キャンサー センター | 痛み治療用の4,5a−エポキシモルフィナンの6−アミド誘導体 |
CN103327977B (zh) * | 2011-01-31 | 2016-05-04 | 东丽株式会社 | 恶液质的治疗或预防剂 |
-
2011
- 2011-10-19 JP JP2013535029A patent/JP6013345B2/ja active Active
- 2011-10-19 KR KR1020137012499A patent/KR101960107B1/ko active IP Right Grant
- 2011-10-19 ES ES11835042.0T patent/ES2632932T3/es active Active
- 2011-10-19 CA CA2814795A patent/CA2814795C/en active Active
- 2011-10-19 MX MX2013004280A patent/MX345624B/es active IP Right Grant
- 2011-10-19 BR BR112013009505-9A patent/BR112013009505B1/pt active IP Right Grant
- 2011-10-19 US US13/879,908 patent/US20130289060A1/en not_active Abandoned
- 2011-10-19 WO PCT/US2011/056827 patent/WO2012054566A2/en active Application Filing
- 2011-10-19 AU AU2011317183A patent/AU2011317183B2/en active Active
- 2011-10-19 EP EP11835042.0A patent/EP2630150B1/en active Active
- 2011-10-19 CN CN201180061032.7A patent/CN103261203B/zh active Active
-
2013
- 2013-04-14 IL IL225755A patent/IL225755B/en active IP Right Grant
-
2014
- 2014-05-19 US US14/281,237 patent/US9725457B2/en active Active
-
2017
- 2017-08-08 US US15/672,245 patent/US10150775B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP6013345B2 (ja) | 2016-10-25 |
MX2013004280A (es) | 2013-10-17 |
US20140255308A1 (en) | 2014-09-11 |
US10150775B2 (en) | 2018-12-11 |
ES2632932T3 (es) | 2017-09-18 |
WO2012054566A3 (en) | 2012-07-19 |
CN103261203B (zh) | 2017-06-20 |
CN103261203A (zh) | 2013-08-21 |
WO2012054566A2 (en) | 2012-04-26 |
CA2814795A1 (en) | 2012-04-26 |
EP2630150A4 (en) | 2014-04-30 |
IL225755B (en) | 2018-10-31 |
CA2814795C (en) | 2018-02-27 |
IL225755A0 (en) | 2013-06-27 |
AU2011317183B2 (en) | 2016-10-20 |
US20180057504A1 (en) | 2018-03-01 |
US20130289060A1 (en) | 2013-10-31 |
AU2011317183A1 (en) | 2013-05-09 |
KR20130121110A (ko) | 2013-11-05 |
KR101960107B1 (ko) | 2019-03-19 |
US9725457B2 (en) | 2017-08-08 |
EP2630150A2 (en) | 2013-08-28 |
EP2630150B1 (en) | 2017-04-12 |
BR112013009505B1 (pt) | 2022-06-21 |
BR112013009505A2 (pt) | 2016-07-26 |
JP2013541559A (ja) | 2013-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |