MX340559B - Proteinas de tcr de alta afinidad y metodos. - Google Patents
Proteinas de tcr de alta afinidad y metodos.Info
- Publication number
- MX340559B MX340559B MX2012000116A MX2012000116A MX340559B MX 340559 B MX340559 B MX 340559B MX 2012000116 A MX2012000116 A MX 2012000116A MX 2012000116 A MX2012000116 A MX 2012000116A MX 340559 B MX340559 B MX 340559B
- Authority
- MX
- Mexico
- Prior art keywords
- cell receptor
- coding sequence
- tcrs
- high affinity
- methods
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
Abstract
La presente invención se refiere a un método in vitro para clonar el gen para un mutante de TCR de alta afinidad en un sistema que permite la expresión del mutante sobre la superficie de células T, caracterizado porque comprende las etapas de: mutar las TCR para crear mutantes de TCR de alta afinidad los cuales tienen una afinidad por su ligando relacionado de entre 107 M-1 y 1010 M-1, en donde los mutantes de TCR de alta afinidad portan una o más mutaciones en una CDR, y en donde las mutaciones son una o más de los residuos 93 a 104 de CDR3? o uno o más de los residuos 95 a 107 de CDR3ß; clonar los mutantes de TCR en un vector; transfectar el vector en células T; y expresar el mutante de TCR de alta afinidad sobre la superficie de células t, en donde el ligando es un ligando péptido/MHC. El método de las células transfectadas se usan para reconocimiento de células MHC que presentan el péptido seleccionado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16917999P | 1999-12-06 | 1999-12-06 | |
PCT/US2000/042622 WO2001048145A2 (en) | 1999-12-06 | 2000-12-06 | High affinity tcr proteins and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
MX340559B true MX340559B (es) | 2016-07-14 |
Family
ID=22614526
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02005559A MXPA02005559A (es) | 1999-12-06 | 2000-12-06 | Proteinas de tcr de alta afinidad y metodos. |
MX2012000116A MX340559B (es) | 1999-12-06 | 2000-12-06 | Proteinas de tcr de alta afinidad y metodos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02005559A MXPA02005559A (es) | 1999-12-06 | 2000-12-06 | Proteinas de tcr de alta afinidad y metodos. |
Country Status (9)
Country | Link |
---|---|
EP (4) | EP2287185A3 (es) |
JP (4) | JP4972264B2 (es) |
AT (1) | ATE411522T1 (es) |
AU (1) | AU5076301A (es) |
CA (1) | CA2406668C (es) |
DE (1) | DE60040556D1 (es) |
DK (1) | DK1247095T3 (es) |
MX (2) | MXPA02005559A (es) |
WO (1) | WO2001048145A2 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6696251B1 (en) | 1996-05-31 | 2004-02-24 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
US20020165149A1 (en) * | 2000-12-08 | 2002-11-07 | Kranz David M. | Mutated class II major histocompatibility proteins |
US20050069549A1 (en) | 2002-01-14 | 2005-03-31 | William Herman | Targeted ligands |
WO2005009948A2 (en) * | 2002-08-29 | 2005-02-03 | Baylor College Of Medicine | Peptide inhibitors of beta-lactamases |
CN1901839A (zh) | 2003-11-10 | 2007-01-24 | 阿尔特生物科学公司 | 可溶性tcr分子及其用途 |
ATE425186T1 (de) | 2005-01-05 | 2009-03-15 | F Star Biotech Forsch & Entw | Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften |
JP5080440B2 (ja) * | 2005-03-18 | 2012-11-21 | ノボザイムス アデニウム バイオテック アクティーゼルスカブ | 抗菌活性を有するポリペプチド及びそれをコードするポリヌクレオチド |
US7534762B2 (en) | 2005-03-18 | 2009-05-19 | Novozymes A/S | Polypeptides having antimicrobial activity and polynucleotides encoding same |
AT503861B1 (de) * | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von t-zell-rezeptoren |
AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
JP5602625B2 (ja) | 2007-06-26 | 2014-10-08 | エフ−スター ビオテヒノロギッシェ フォルシュングス− ウント エントヴィッケルングスゲゼルシャフト ミット ベシュレンクテル ハフツング | 結合物質のディスプレイ |
EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
CN105247059B (zh) | 2013-03-28 | 2021-07-06 | 莫迪卡戈公司 | 植物中流感样病毒颗粒的产生 |
US11441150B2 (en) | 2014-01-10 | 2022-09-13 | Medicago Inc. | CPMV enhancer elements |
EP3116901B1 (en) | 2014-03-14 | 2019-06-12 | Immunocore Limited | Tcr libraries |
WO2015143567A1 (en) | 2014-03-27 | 2015-10-01 | Medicago Inc. | Modified cpmv enhancer elements |
GB201516277D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
GB201516269D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
GB201516272D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
GB201516265D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
GB201516275D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
GB201604953D0 (en) | 2016-03-23 | 2016-05-04 | Immunocore Ltd | T cell receptors |
MD3440105T2 (ro) | 2016-04-08 | 2022-09-30 | Immunocore Ltd | Receptori de celulă T |
GB201709866D0 (en) | 2017-06-20 | 2017-08-02 | Immunocore Ltd | T cell receptors |
CN109777778B (zh) * | 2017-11-14 | 2023-07-18 | 中国科学院广州生物医药与健康研究院 | 一种基因改造的γδT细胞 |
JPWO2019151392A1 (ja) * | 2018-01-31 | 2021-02-04 | 国立大学法人東北大学 | 抗原特異的mhc発現調節法 |
US20220275043A1 (en) | 2018-07-17 | 2022-09-01 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
GB201904328D0 (en) | 2019-03-28 | 2019-05-15 | Immunocore Ltd | Specific binding molecules |
US20210032370A1 (en) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Recruiting agent further binding an mhc molecule |
DE102019121007A1 (de) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigenbindende Proteine, die spezifisch an MAGE-A binden |
US20210048442A1 (en) * | 2019-08-13 | 2021-02-18 | Immatics Biotechnologies Gmbh | Method for the characterization of peptide:mhc binding polypeptides |
GB201915282D0 (en) | 2019-10-22 | 2019-12-04 | Immunocore Ltd | Specific binding molecules |
EP4090365A1 (en) | 2020-01-15 | 2022-11-23 | Immatics Biotechnologies GmbH | Antigen binding proteins specifically binding prame |
GB202006629D0 (en) | 2020-05-05 | 2020-06-17 | Immunocore Ltd | Specific binding molecules |
GB202010329D0 (en) | 2020-07-06 | 2020-08-19 | Immunocore Ltd | Specific binding molecules |
WO2022184805A1 (en) | 2021-03-03 | 2022-09-09 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding sars-cov-2 antigenic peptides in complex with a major histocompatibility complex protein |
BR112023022765A2 (pt) | 2021-05-05 | 2024-01-02 | Immatics Biotechnologies Gmbh | Proteínas de ligação ao antígeno que ligam especificamente o prame |
WO2023156663A1 (en) | 2022-02-20 | 2023-08-24 | Immunocore Limited | Hiv-specific binding molecules and tcr |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
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NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3927193A (en) | 1973-05-18 | 1975-12-16 | Hoffmann La Roche | Localization of tumors by radiolabelled antibodies |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4361544A (en) | 1980-03-03 | 1982-11-30 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
US4348376A (en) | 1980-03-03 | 1982-09-07 | Goldenberg Milton David | Tumor localization and therapy with labeled anti-CEA antibody |
US4444744A (en) | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
US4468457A (en) | 1981-06-01 | 1984-08-28 | David M. Goldenberg | Method for producing a CSAp tryptic peptide and anti-CSAp antibodies |
US5101827A (en) | 1985-07-05 | 1992-04-07 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
US4640561A (en) | 1985-11-15 | 1987-02-03 | Ford Motor Company | Flexible printed circuit connector |
US5059413A (en) | 1988-04-18 | 1991-10-22 | Xoma Corporation | Scintigraphic monitoring of immunotoxins using radionuclides and heterobifunctional chelators |
ES2125854T3 (es) | 1989-08-09 | 1999-03-16 | Rhomed Inc | Radiomarcado directo de anticuerpos y otras proteinas con tecnetio o renio. |
US5299253A (en) | 1992-04-10 | 1994-03-29 | Akzo N.V. | Alignment system to overlay abdominal computer aided tomography and magnetic resonance anatomy with single photon emission tomography |
US5861156A (en) * | 1993-01-08 | 1999-01-19 | Creative Biomolecules | Methods of delivering agents to target cells |
US6300065B1 (en) * | 1996-05-31 | 2001-10-09 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
EP0977886A4 (en) * | 1997-03-07 | 2002-10-23 | Sunol Molecular Corp | FUSION PROTEINS, WHICH CONTAIN A BACTERIOPHAGE ENVELOPE PROTEIN AND A SINGLE CHAIN T-CELL RECEPTOR |
-
2000
- 2000-12-06 DK DK00993099T patent/DK1247095T3/da active
- 2000-12-06 AT AT00993099T patent/ATE411522T1/de not_active IP Right Cessation
- 2000-12-06 EP EP10184889A patent/EP2287185A3/en not_active Withdrawn
- 2000-12-06 WO PCT/US2000/042622 patent/WO2001048145A2/en active Application Filing
- 2000-12-06 MX MXPA02005559A patent/MXPA02005559A/es active IP Right Grant
- 2000-12-06 AU AU50763/01A patent/AU5076301A/en not_active Abandoned
- 2000-12-06 EP EP08075788.3A patent/EP2042869B1/en not_active Expired - Lifetime
- 2000-12-06 JP JP2001548658A patent/JP4972264B2/ja not_active Expired - Lifetime
- 2000-12-06 EP EP10183227A patent/EP2336775A3/en not_active Withdrawn
- 2000-12-06 MX MX2012000116A patent/MX340559B/es unknown
- 2000-12-06 DE DE60040556T patent/DE60040556D1/de not_active Expired - Lifetime
- 2000-12-06 CA CA2406668A patent/CA2406668C/en not_active Expired - Lifetime
- 2000-12-06 EP EP00993099A patent/EP1247095B1/en not_active Expired - Lifetime
-
2010
- 2010-12-17 JP JP2010282453A patent/JP2011101649A/ja not_active Withdrawn
-
2011
- 2011-12-29 JP JP2011290233A patent/JP2012065672A/ja active Pending
-
2014
- 2014-01-17 JP JP2014006599A patent/JP2014095722A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ATE411522T1 (de) | 2008-10-15 |
AU5076301A (en) | 2001-07-09 |
MXPA02005559A (es) | 2004-09-10 |
JP2003518377A (ja) | 2003-06-10 |
EP1247095A4 (en) | 2003-04-02 |
EP2042869A3 (en) | 2009-06-17 |
EP2287185A3 (en) | 2012-10-10 |
WO2001048145A2 (en) | 2001-07-05 |
DK1247095T3 (da) | 2008-12-08 |
CA2406668A1 (en) | 2001-07-05 |
EP1247095B1 (en) | 2008-10-15 |
EP2287185A2 (en) | 2011-02-23 |
JP2011101649A (ja) | 2011-05-26 |
EP2042869B1 (en) | 2017-10-04 |
CA2406668C (en) | 2015-11-24 |
JP2014095722A (ja) | 2014-05-22 |
EP2336775A3 (en) | 2013-03-20 |
JP4972264B2 (ja) | 2012-07-11 |
EP2042869A2 (en) | 2009-04-01 |
EP2336775A2 (en) | 2011-06-22 |
DE60040556D1 (de) | 2008-11-27 |
JP2012065672A (ja) | 2012-04-05 |
EP1247095A2 (en) | 2002-10-09 |
WO2001048145A3 (en) | 2002-01-10 |
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