MX340559B - Proteinas de tcr de alta afinidad y metodos. - Google Patents

Proteinas de tcr de alta afinidad y metodos.

Info

Publication number
MX340559B
MX340559B MX2012000116A MX2012000116A MX340559B MX 340559 B MX340559 B MX 340559B MX 2012000116 A MX2012000116 A MX 2012000116A MX 2012000116 A MX2012000116 A MX 2012000116A MX 340559 B MX340559 B MX 340559B
Authority
MX
Mexico
Prior art keywords
cell receptor
coding sequence
tcrs
high affinity
methods
Prior art date
Application number
MX2012000116A
Other languages
English (en)
Inventor
M Kranz David
D Holler Phillip
K Wittrup Dane
Original Assignee
Board Of Trustees Of The Univ Of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Board Of Trustees Of The Univ Of Illinois filed Critical Board Of Trustees Of The Univ Of Illinois
Publication of MX340559B publication Critical patent/MX340559B/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)

Abstract

La presente invención se refiere a un método in vitro para clonar el gen para un mutante de TCR de alta afinidad en un sistema que permite la expresión del mutante sobre la superficie de células T, caracterizado porque comprende las etapas de: mutar las TCR para crear mutantes de TCR de alta afinidad los cuales tienen una afinidad por su ligando relacionado de entre 107 M-1 y 1010 M-1, en donde los mutantes de TCR de alta afinidad portan una o más mutaciones en una CDR, y en donde las mutaciones son una o más de los residuos 93 a 104 de CDR3? o uno o más de los residuos 95 a 107 de CDR3ß; clonar los mutantes de TCR en un vector; transfectar el vector en células T; y expresar el mutante de TCR de alta afinidad sobre la superficie de células t, en donde el ligando es un ligando péptido/MHC. El método de las células transfectadas se usan para reconocimiento de células MHC que presentan el péptido seleccionado.
MX2012000116A 1999-12-06 2000-12-06 Proteinas de tcr de alta afinidad y metodos. MX340559B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16917999P 1999-12-06 1999-12-06
PCT/US2000/042622 WO2001048145A2 (en) 1999-12-06 2000-12-06 High affinity tcr proteins and methods

Publications (1)

Publication Number Publication Date
MX340559B true MX340559B (es) 2016-07-14

Family

ID=22614526

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012000116A MX340559B (es) 1999-12-06 2000-12-06 Proteinas de tcr de alta afinidad y metodos.
MXPA02005559A MXPA02005559A (es) 1999-12-06 2000-12-06 Proteinas de tcr de alta afinidad y metodos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MXPA02005559A MXPA02005559A (es) 1999-12-06 2000-12-06 Proteinas de tcr de alta afinidad y metodos.

Country Status (9)

Country Link
EP (4) EP2336775A3 (es)
JP (4) JP4972264B2 (es)
AT (1) ATE411522T1 (es)
AU (1) AU5076301A (es)
CA (1) CA2406668C (es)
DE (1) DE60040556D1 (es)
DK (1) DK1247095T3 (es)
MX (2) MX340559B (es)
WO (1) WO2001048145A2 (es)

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Also Published As

Publication number Publication date
CA2406668C (en) 2015-11-24
DK1247095T3 (da) 2008-12-08
JP2003518377A (ja) 2003-06-10
WO2001048145A3 (en) 2002-01-10
WO2001048145A2 (en) 2001-07-05
JP2012065672A (ja) 2012-04-05
CA2406668A1 (en) 2001-07-05
JP2014095722A (ja) 2014-05-22
ATE411522T1 (de) 2008-10-15
JP4972264B2 (ja) 2012-07-11
DE60040556D1 (de) 2008-11-27
EP2336775A2 (en) 2011-06-22
AU5076301A (en) 2001-07-09
EP2042869A3 (en) 2009-06-17
EP2287185A3 (en) 2012-10-10
EP2287185A2 (en) 2011-02-23
EP2042869A2 (en) 2009-04-01
EP1247095B1 (en) 2008-10-15
JP2011101649A (ja) 2011-05-26
EP2042869B1 (en) 2017-10-04
EP2336775A3 (en) 2013-03-20
EP1247095A2 (en) 2002-10-09
MXPA02005559A (es) 2004-09-10
EP1247095A4 (en) 2003-04-02

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