MX2023012826A - Tratamiento de enfermedades oculares utilizando antagonistas del receptor de endotelina. - Google Patents
Tratamiento de enfermedades oculares utilizando antagonistas del receptor de endotelina.Info
- Publication number
- MX2023012826A MX2023012826A MX2023012826A MX2023012826A MX2023012826A MX 2023012826 A MX2023012826 A MX 2023012826A MX 2023012826 A MX2023012826 A MX 2023012826A MX 2023012826 A MX2023012826 A MX 2023012826A MX 2023012826 A MX2023012826 A MX 2023012826A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- receptor antagonists
- endothelin receptor
- ocular diseases
- diseases
- Prior art date
Links
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
- 208000022873 Ocular disease Diseases 0.000 title 1
- 239000002308 endothelin receptor antagonist Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 201000006165 Kuhnt-Junius degeneration Diseases 0.000 abstract 1
- 208000001344 Macular Edema Diseases 0.000 abstract 1
- 206010025415 Macular oedema Diseases 0.000 abstract 1
- 206010029113 Neovascularisation Diseases 0.000 abstract 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 abstract 1
- 206010064930 age-related macular degeneration Diseases 0.000 abstract 1
- 229950004880 edonentan Drugs 0.000 abstract 1
- 201000010230 macular retinal edema Diseases 0.000 abstract 1
- VRUJTPHFVRXEPB-UHFFFAOYSA-N n-[[2-[2-[(4,5-dimethyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,3,3-trimethylbutanamide;hydrate Chemical compound O.CC(C)(C)CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=NOC(C)=C1C VRUJTPHFVRXEPB-UHFFFAOYSA-N 0.000 abstract 1
- 201000003142 neovascular glaucoma Diseases 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
- 230000000007 visual effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente descripción se relaciona con el descubrimiento de que ciertas enfermedades del ojo que afectan profundamente el sistema visual humano y, como resultado, la calidad de vida, pueden tratarse usando Edonentan o A-182086. Los ejemplos de las enfermedades incluyen, pero no se limitan a, neovascularización ocular, glaucoma neovascular, fuga vascular, edema macular y degeneración macular neovascular relacionada con la edad.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163182750P | 2021-04-30 | 2021-04-30 | |
PCT/US2022/027045 WO2022232586A1 (en) | 2021-04-30 | 2022-04-29 | Treatment of ocular diseases using endothelin receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023012826A true MX2023012826A (es) | 2023-11-13 |
Family
ID=83848733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023012826A MX2023012826A (es) | 2021-04-30 | 2022-04-29 | Tratamiento de enfermedades oculares utilizando antagonistas del receptor de endotelina. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20240058265A1 (es) |
EP (1) | EP4329810A1 (es) |
JP (1) | JP2024516829A (es) |
CN (1) | CN117295520A (es) |
AU (1) | AU2022264438A1 (es) |
CA (1) | CA3218398A1 (es) |
IL (1) | IL307794A (es) |
MX (1) | MX2023012826A (es) |
WO (1) | WO2022232586A1 (es) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120087864A1 (en) * | 2010-04-12 | 2012-04-12 | R-Tech Ueno, Ltd. | Method for diagnosing and/or evaluating retinal disease |
JP2017519813A (ja) * | 2014-05-23 | 2017-07-20 | オキュラー テクノロジーズ エスアーエールエル | 局所製剤およびその使用 |
WO2018185516A1 (en) * | 2017-04-05 | 2018-10-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cardiovascular toxicity induced by anti-cancer therapy |
WO2019018350A1 (en) * | 2017-07-17 | 2019-01-24 | Keith Roizman | TOPICAL ADMINISTRATION OF THERAPEUTIC AGENTS COMPRISING CELL PENETRATION PEPTIDES, FOR USE IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND OTHER OCULAR DISEASES |
CN114786480B (zh) * | 2019-10-30 | 2024-03-29 | 珀弗斯治疗股份有限公司 | 使用内皮素受体拮抗剂治疗眼部疾病 |
-
2022
- 2022-04-29 CA CA3218398A patent/CA3218398A1/en active Pending
- 2022-04-29 JP JP2023566519A patent/JP2024516829A/ja active Pending
- 2022-04-29 EP EP22796855.9A patent/EP4329810A1/en active Pending
- 2022-04-29 IL IL307794A patent/IL307794A/en unknown
- 2022-04-29 AU AU2022264438A patent/AU2022264438A1/en active Pending
- 2022-04-29 CN CN202280032071.2A patent/CN117295520A/zh active Pending
- 2022-04-29 WO PCT/US2022/027045 patent/WO2022232586A1/en active Application Filing
- 2022-04-29 MX MX2023012826A patent/MX2023012826A/es unknown
-
2023
- 2023-10-25 US US18/494,545 patent/US20240058265A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3218398A1 (en) | 2022-11-03 |
JP2024516829A (ja) | 2024-04-17 |
EP4329810A1 (en) | 2024-03-06 |
CN117295520A (zh) | 2023-12-26 |
IL307794A (en) | 2023-12-01 |
AU2022264438A1 (en) | 2023-11-23 |
WO2022232586A1 (en) | 2022-11-03 |
US20240058265A1 (en) | 2024-02-22 |
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