MX2023011017A - Composiciones y sistemas para la determinacion de la funcion renal. - Google Patents

Composiciones y sistemas para la determinacion de la funcion renal.

Info

Publication number
MX2023011017A
MX2023011017A MX2023011017A MX2023011017A MX2023011017A MX 2023011017 A MX2023011017 A MX 2023011017A MX 2023011017 A MX2023011017 A MX 2023011017A MX 2023011017 A MX2023011017 A MX 2023011017A MX 2023011017 A MX2023011017 A MX 2023011017A
Authority
MX
Mexico
Prior art keywords
systems
renal function
patient
compositions
function determination
Prior art date
Application number
MX2023011017A
Other languages
English (en)
Inventor
Thomas E Rogers
Richard B Dorshow
William L Neumann
Martin P Debreczeny
Raghavan Rajagopalan
Original Assignee
Medibeacon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medibeacon Inc filed Critical Medibeacon Inc
Publication of MX2023011017A publication Critical patent/MX2023011017A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
    • A61B5/201—Assessing renal or kidney functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1495—Calibrating or testing of in-vivo probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6815—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Physiology (AREA)
  • Signal Processing (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Otolaryngology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a sistemas y métodos para determinar la tasa de filtración glomerular renal o evaluar la función renal en un paciente en necesidad de los mismos. El sistema incluye un dispositivo informático, un suministro de energía, uno o más sensores y al menos un agente trazador que fluoresce cuando se expone a la radiación electromagnética. La radiación electromagnética se detecta usando los sensores y la tasa a la que disminuye la fluorescencia en el paciente se usa para calcular la tasa de filtración glomerular renal en el paciente.
MX2023011017A 2017-10-27 2019-10-04 Composiciones y sistemas para la determinacion de la funcion renal. MX2023011017A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762577962P 2017-10-27 2017-10-27

Publications (1)

Publication Number Publication Date
MX2023011017A true MX2023011017A (es) 2023-09-27

Family

ID=66245914

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019011977A MX2019011977A (es) 2017-10-27 2018-10-26 Composiciones y sistemas para la determinacion de la funcion renal.
MX2023011017A MX2023011017A (es) 2017-10-27 2019-10-04 Composiciones y sistemas para la determinacion de la funcion renal.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019011977A MX2019011977A (es) 2017-10-27 2018-10-26 Composiciones y sistemas para la determinacion de la funcion renal.

Country Status (16)

Country Link
US (2) US11602570B2 (es)
EP (1) EP3700578A4 (es)
JP (3) JP7202355B2 (es)
KR (3) KR20200010191A (es)
CN (1) CN110494167A (es)
AU (1) AU2018355541B2 (es)
BR (1) BR112019020605A2 (es)
CA (1) CA3058772C (es)
IL (2) IL269617B2 (es)
MX (2) MX2019011977A (es)
MY (1) MY197859A (es)
NZ (1) NZ757917A (es)
PH (1) PH12019502352A1 (es)
RU (2) RU2760279C2 (es)
SG (1) SG11201909368TA (es)
WO (1) WO2019084475A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019032746A1 (en) 2017-08-08 2019-02-14 Fresenius Medical Care Holdings, Inc. SYSTEMS AND METHODS FOR TREATING AND ESTIMATING THE PROGRESSION OF CHRONIC RENAL DISEASE
KR20210102371A (ko) * 2018-12-12 2021-08-19 메디비콘 아이엔씨. 지속적 신장 대체 요법에서 경피 사구체 여과율 측정의 용도
JP2023540433A (ja) * 2020-07-24 2023-09-25 メディビーコン，インク． 消化管機能を在宅で経皮的に評価するためのシステム及び方法
EP4313173A1 (en) * 2021-03-31 2024-02-07 MediBeacon Inc. Purification of substituted diaminopyrazine dicarboxylic acids
TW202321203A (zh) * 2021-08-11 2023-06-01 中國大陸商杭州中美華東製藥有限公司 製備作為螢光示蹤劑的吡嗪羧酸類衍生物的方法
TW202319052A (zh) * 2021-08-27 2023-05-16 中國大陸商杭州中美華東製藥有限公司 吡嗪類衍生物的晶型及其製備方法
WO2023046046A1 (zh) * 2021-09-24 2023-03-30 杭州中美华东制药有限公司 用于制备作为荧光示踪剂的吡嗪羧酸类衍生物的氢化合成方法
WO2023078440A1 (zh) * 2021-11-08 2023-05-11 杭州中美华东制药有限公司 吡嗪类衍生物的盐的晶型及其制备方法

Family Cites Families (24)

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US5301673A (en) * 1991-11-18 1994-04-12 Massachusetts General Hospital Ambulatory clearance function monitor
US6280703B1 (en) * 1997-03-13 2001-08-28 Mallinckrodt Inc. Simultaneous multimodal measurement of physiological function
US6909912B2 (en) 2002-06-20 2005-06-21 University Of Florida Non-invasive perfusion monitor and system, specially configured oximeter probes, methods of using same, and covers for probes
ATE539674T1 (de) 2003-04-24 2012-01-15 Univ Texas Nichtinvasive blutanalyse durch optische sondierung der venen unter der zunge
US20060095102A1 (en) 2003-09-17 2006-05-04 Thomas Perez Method and apparatus for sublingual application of light to blood
US8664392B2 (en) 2004-12-23 2014-03-04 Medibeacon, LLC Pyrazine derivatives for bioconjugation
ES2375395T3 (es) 2004-12-23 2012-02-29 Mallinckrodt Llc Derivados de pirazina fluorescentes y método de uso de los mismos en la evaluación de la función renal.
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ES2390314T3 (es) 2006-02-24 2012-11-08 Medibeacon Development, Llc Agentes ópticos para uso en cirugía
CA2655857C (en) 2006-06-22 2014-12-02 Mallinckrodt Inc. Pyrazine derivatives with extended conjugation and uses thereof
JP2009534396A (ja) * 2006-06-22 2009-09-24 マリンクロッド・インコーポレイテッド ピラジン誘導体および腎臓の監視におけるその使用
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CA2747402A1 (en) 2008-12-17 2010-07-08 Amruta Poreddy Modified pyrazine derivatives and uses thereof
US9554739B2 (en) * 2009-09-29 2017-01-31 Covidien Lp Smart cable for coupling a medical sensor to an electronic patient monitor
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Also Published As

Publication number Publication date
US20190125901A1 (en) 2019-05-02
IL269617B2 (en) 2024-09-01
KR20220003659A (ko) 2022-01-10
WO2019084475A1 (en) 2019-05-02
RU2019132431A (ru) 2021-04-14
CN110494167A (zh) 2019-11-22
US20230173111A1 (en) 2023-06-08
AU2018355541A1 (en) 2019-10-31
MY197859A (en) 2023-07-20
CA3058772A1 (en) 2019-05-02
IL269617A (en) 2019-11-28
EP3700578A1 (en) 2020-09-02
PH12019502352A1 (en) 2020-12-07
IL269617B1 (en) 2024-05-01
JP2023175915A (ja) 2023-12-12
BR112019020605A2 (pt) 2020-04-22
RU2019132431A3 (es) 2021-04-14
JP7202355B2 (ja) 2023-01-11
JP2023009041A (ja) 2023-01-19
IL312255A (en) 2024-06-01
CA3058772C (en) 2023-08-08
JP2020516680A (ja) 2020-06-11
EP3700578A4 (en) 2021-08-04
RU2760279C2 (ru) 2021-11-23
JP7362869B2 (ja) 2023-10-17
US11602570B2 (en) 2023-03-14
SG11201909368TA (en) 2019-11-28
RU2021133174A (ru) 2021-12-02
NZ757917A (en) 2022-04-29
KR20230054506A (ko) 2023-04-24
MX2019011977A (es) 2020-01-27
KR20200010191A (ko) 2020-01-30
AU2018355541B2 (en) 2020-11-19

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