MX2019011977A - Composiciones y sistemas para la determinacion de la funcion renal. - Google Patents

Composiciones y sistemas para la determinacion de la funcion renal.

Info

Publication number
MX2019011977A
MX2019011977A MX2019011977A MX2019011977A MX2019011977A MX 2019011977 A MX2019011977 A MX 2019011977A MX 2019011977 A MX2019011977 A MX 2019011977A MX 2019011977 A MX2019011977 A MX 2019011977A MX 2019011977 A MX2019011977 A MX 2019011977A
Authority
MX
Mexico
Prior art keywords
systems
renal function
patient
compositions
function determination
Prior art date
Application number
MX2019011977A
Other languages
English (en)
Inventor
e rogers Thomas
B Dorshow Richard
L Neumann William
P Debreczeny Martin
Rajagopalan Raghavan
Original Assignee
Medibeacon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medibeacon Inc filed Critical Medibeacon Inc
Publication of MX2019011977A publication Critical patent/MX2019011977A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
    • A61B5/201—Assessing renal or kidney functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6815—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1495—Calibrating or testing of in-vivo probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Abstract

La presente invención se refiere a sistemas y métodos para determinar la tasa de filtración glomerular renal o evaluar la función renal en un paciente en necesidad de los mismos. El sistema incluye un dispositivo informático, un suministro de energía, uno o más sensores y al menos un agente trazador que fluoresce cuando se expone a la radiación electromagnética. La radiación electromagnética se detecta usando los sensores y la tasa a la que disminuye la fluorescencia en el paciente se usa para calcular la tasa de filtración glomerular renal en el paciente.
MX2019011977A 2017-10-27 2018-10-26 Composiciones y sistemas para la determinacion de la funcion renal. MX2019011977A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762577962P 2017-10-27 2017-10-27
PCT/US2018/057820 WO2019084475A1 (en) 2017-10-27 2018-10-26 COMPOSITIONS AND SYSTEMS FOR MEASURING RENAL FUNCTION

Publications (1)

Publication Number Publication Date
MX2019011977A true MX2019011977A (es) 2020-01-27

Family

ID=66245914

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011977A MX2019011977A (es) 2017-10-27 2018-10-26 Composiciones y sistemas para la determinacion de la funcion renal.

Country Status (16)

Country Link
US (2) US11602570B2 (es)
EP (1) EP3700578A4 (es)
JP (3) JP7202355B2 (es)
KR (3) KR20230054506A (es)
CN (1) CN110494167A (es)
AU (1) AU2018355541B2 (es)
BR (1) BR112019020605A2 (es)
CA (1) CA3058772C (es)
IL (1) IL269617A (es)
MX (1) MX2019011977A (es)
MY (1) MY197859A (es)
NZ (1) NZ757917A (es)
PH (1) PH12019502352A1 (es)
RU (2) RU2021133174A (es)
SG (1) SG11201909368TA (es)
WO (1) WO2019084475A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3665705A1 (en) 2017-08-08 2020-06-17 Fresenius Medical Care Holdings, Inc. Systems and methods for treating and estimating progression of chronic kidney disease
CN111298136A (zh) * 2018-12-12 2020-06-19 麦迪贝肯有限公司 透皮肾小球滤过率测量在连续肾脏置换疗法中的用途
US20220315538A1 (en) * 2021-03-31 2022-10-06 Medibeacon Inc. Purification of substituted diaminopyrazine dicarboxylic acids
WO2023016483A1 (zh) * 2021-08-11 2023-02-16 杭州中美华东制药有限公司 制备作为荧光示踪剂的吡嗪羧酸类衍生物的方法
WO2023025271A1 (zh) * 2021-08-27 2023-03-02 杭州中美华东制药有限公司 吡嗪类衍生物的晶型及其制备方法
WO2023046046A1 (zh) * 2021-09-24 2023-03-30 杭州中美华东制药有限公司 用于制备作为荧光示踪剂的吡嗪羧酸类衍生物的氢化合成方法
WO2023078440A1 (zh) * 2021-11-08 2023-05-11 杭州中美华东制药有限公司 吡嗪类衍生物的盐的晶型及其制备方法

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US6280703B1 (en) * 1997-03-13 2001-08-28 Mallinckrodt Inc. Simultaneous multimodal measurement of physiological function
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AU2004233870B2 (en) 2003-04-24 2009-11-05 The Board Of Regents Of The University Of Texas System Noninvasive blood analysis by optical probing of the veins under the tongue
US20060095102A1 (en) 2003-09-17 2006-05-04 Thomas Perez Method and apparatus for sublingual application of light to blood
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WO2006071759A2 (en) * 2004-12-23 2006-07-06 Mallinckrodt Inc. Fluorescent pyrazine derivatives and methods of using the same in assessing renal function
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US8591865B2 (en) * 2008-04-18 2013-11-26 Pharmacophotonics, Inc. Renal function analysis method and apparatus
EP2376459B1 (en) * 2008-12-17 2015-02-18 MediBeacon, LLC Modified pyrazine derivatives and uses thereof
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US11077211B2 (en) * 2013-11-11 2021-08-03 Medibeacon Inc. Compositions and methods for assessing gut function
JP2016112375A (ja) 2014-12-16 2016-06-23 イオム株式会社 皮膚蛍光測定装置
EP3294296A4 (en) * 2015-05-12 2018-12-26 Medibeacon Inc. Compositions and methods for assessing eye vasculature
BR112019015520A2 (pt) * 2017-01-30 2020-03-17 Medibeacon Inc. Método para monitoramento não invasivo de agente traçador fluorescente com correções de reflexão difusa
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Also Published As

Publication number Publication date
AU2018355541A1 (en) 2019-10-31
IL269617A (en) 2019-11-28
MY197859A (en) 2023-07-20
RU2760279C2 (ru) 2021-11-23
BR112019020605A2 (pt) 2020-04-22
RU2021133174A (ru) 2021-12-02
KR20220003659A (ko) 2022-01-10
EP3700578A4 (en) 2021-08-04
KR20230054506A (ko) 2023-04-24
JP7362869B2 (ja) 2023-10-17
CA3058772C (en) 2023-08-08
JP2020516680A (ja) 2020-06-11
RU2019132431A3 (es) 2021-04-14
PH12019502352A1 (en) 2020-12-07
JP7202355B2 (ja) 2023-01-11
JP2023175915A (ja) 2023-12-12
WO2019084475A1 (en) 2019-05-02
CA3058772A1 (en) 2019-05-02
RU2019132431A (ru) 2021-04-14
EP3700578A1 (en) 2020-09-02
KR20200010191A (ko) 2020-01-30
US11602570B2 (en) 2023-03-14
US20190125901A1 (en) 2019-05-02
CN110494167A (zh) 2019-11-22
SG11201909368TA (en) 2019-11-28
NZ757917A (en) 2022-04-29
US20230173111A1 (en) 2023-06-08
AU2018355541B2 (en) 2020-11-19
JP2023009041A (ja) 2023-01-19

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