MX2023008153A - Metodos y compuestos para tratar la ataxia de friedreich. - Google Patents
Metodos y compuestos para tratar la ataxia de friedreich.Info
- Publication number
- MX2023008153A MX2023008153A MX2023008153A MX2023008153A MX2023008153A MX 2023008153 A MX2023008153 A MX 2023008153A MX 2023008153 A MX2023008153 A MX 2023008153A MX 2023008153 A MX2023008153 A MX 2023008153A MX 2023008153 A MX2023008153 A MX 2023008153A
- Authority
- MX
- Mexico
- Prior art keywords
- terminus
- compounds
- methods
- binding
- ataxia
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 208000024412 Friedreich ataxia Diseases 0.000 title 1
- 230000027455 binding Effects 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000004568 DNA-binding Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyethers (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163135427P | 2021-01-08 | 2021-01-08 | |
| PCT/US2022/011560 WO2022150555A2 (en) | 2021-01-08 | 2022-01-07 | Methods and compounds for treating friedreich's ataxia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023008153A true MX2023008153A (es) | 2023-09-21 |
Family
ID=82358799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023008153A MX2023008153A (es) | 2021-01-08 | 2022-01-07 | Metodos y compuestos para tratar la ataxia de friedreich. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240124491A1 (enExample) |
| EP (1) | EP4274583A4 (enExample) |
| JP (1) | JP2024502469A (enExample) |
| CN (1) | CN117241805A (enExample) |
| AR (1) | AR124589A1 (enExample) |
| AU (1) | AU2022206424A1 (enExample) |
| CA (1) | CA3204523A1 (enExample) |
| IL (1) | IL304322A (enExample) |
| MX (1) | MX2023008153A (enExample) |
| TW (1) | TW202241892A (enExample) |
| WO (1) | WO2022150555A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117241805A (zh) * | 2021-01-08 | 2023-12-15 | 设计治疗公司 | 用于治疗弗里德希氏共济失调的方法和化合物 |
| TW202334148A (zh) * | 2022-01-06 | 2023-09-01 | 美商規劃醫療公司 | 用於治療弗里德希氏共濟失調（ｆｒｉｅｄｒｅｉｃｈ＇ｓ ａｔａｘｉａ）之化合物及方法 |
| WO2025067451A1 (zh) * | 2023-09-27 | 2025-04-03 | 北京沐华生物科技有限责任公司 | 一类brd4蛋白降解剂化合物及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060270727A1 (en) * | 2005-05-03 | 2006-11-30 | Christian Melander | Small molecule therapeutics and uses therefor |
| WO2015074081A1 (en) * | 2013-11-18 | 2015-05-21 | Bair Kenneth W | Benzopiperazine compositions as bet bromodomain inhibitors |
| GB201504314D0 (en) * | 2015-03-13 | 2015-04-29 | Univ Dundee | Small molecules |
| ES3037659T3 (en) * | 2016-03-30 | 2025-10-03 | Wisconsin Alumni Res Found | Methods and compositions for modulating frataxin expression |
| ES2793239T3 (es) * | 2016-04-15 | 2020-11-13 | Abbvie Inc | Inhibidores del bromodominio |
| US20210283265A1 (en) * | 2018-04-20 | 2021-09-16 | Design Therapeutics, Inc. | Methods and compounds for the treatment of genetic disease |
| WO2019226836A1 (en) * | 2018-05-22 | 2019-11-28 | Design Therapeutics Inc. | Methods and compounds for the treatment of genetic disease |
| WO2020056188A1 (en) * | 2018-09-12 | 2020-03-19 | Board Of Regents, The University Of Texas System | Combination of parp inhibitor and brd4 inhibitor for the treatment of cancer |
| EP4100404A4 (en) * | 2020-02-03 | 2024-05-22 | Design Therapeutics, Inc. | METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASES |
| CN117279636A (zh) * | 2020-12-11 | 2023-12-22 | 设计治疗公司 | 用于调节强直性肌营养不良1型的方法和化合物 |
| CN117241805A (zh) * | 2021-01-08 | 2023-12-15 | 设计治疗公司 | 用于治疗弗里德希氏共济失调的方法和化合物 |
-
2022
- 2022-01-07 CN CN202280018641.2A patent/CN117241805A/zh active Pending
- 2022-01-07 TW TW111100817A patent/TW202241892A/zh unknown
- 2022-01-07 US US18/260,549 patent/US20240124491A1/en active Pending
- 2022-01-07 MX MX2023008153A patent/MX2023008153A/es unknown
- 2022-01-07 EP EP22737158.0A patent/EP4274583A4/en active Pending
- 2022-01-07 AR ARP220100032A patent/AR124589A1/es unknown
- 2022-01-07 WO PCT/US2022/011560 patent/WO2022150555A2/en not_active Ceased
- 2022-01-07 CA CA3204523A patent/CA3204523A1/en active Pending
- 2022-01-07 AU AU2022206424A patent/AU2022206424A1/en active Pending
- 2022-01-07 JP JP2023541510A patent/JP2024502469A/ja active Pending
-
2023
- 2023-07-09 IL IL304322A patent/IL304322A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4274583A4 (en) | 2025-01-22 |
| IL304322A (en) | 2023-09-01 |
| AR124589A1 (es) | 2023-04-12 |
| US20240124491A1 (en) | 2024-04-18 |
| CN117241805A (zh) | 2023-12-15 |
| WO2022150555A3 (en) | 2022-12-22 |
| EP4274583A2 (en) | 2023-11-15 |
| TW202241892A (zh) | 2022-11-01 |
| WO2022150555A2 (en) | 2022-07-14 |
| CA3204523A1 (en) | 2022-07-14 |
| AU2022206424A1 (en) | 2023-08-24 |
| AU2022206424A9 (en) | 2024-09-19 |
| JP2024502469A (ja) | 2024-01-19 |
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