MX2023005639A - Comprimidos de capa doble orales que comprenden acido acetilsalicilico y pseudoefedrina, metodos para preparar y utilizar los mismos. - Google Patents

Comprimidos de capa doble orales que comprenden acido acetilsalicilico y pseudoefedrina, metodos para preparar y utilizar los mismos.

Info

Publication number
MX2023005639A
MX2023005639A MX2023005639A MX2023005639A MX2023005639A MX 2023005639 A MX2023005639 A MX 2023005639A MX 2023005639 A MX2023005639 A MX 2023005639A MX 2023005639 A MX2023005639 A MX 2023005639A MX 2023005639 A MX2023005639 A MX 2023005639A
Authority
MX
Mexico
Prior art keywords
bilayer tablets
acetylsalicylic acid
pseudoephedrine
preparing
methods
Prior art date
Application number
MX2023005639A
Other languages
English (en)
Inventor
Harsh Mehta
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of MX2023005639A publication Critical patent/MX2023005639A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente descripción se refiere en general a comprimidos de capa doble que comprenden una combinación de dos ingredientes farmacéuticos activos, y más específicamente a comprimidos de capa doble que comprenden ácido acetilsalicílico, pseudoefedrina y un coadyuvante de disolución. Los comprimidos de capa doble utilizan una combinación de ácido acetilsalicílico granulado y no granulado junto con una distribución única de carbonato de sodio como coadyuvante de disolución que proporciona ácido acetilsalicílico y pseudoefedrina en una única forma farmacéutica de rápida disolución y estabilidad de almacenamiento a largo plazo (baja degradación). La presente descripción también proporciona métodos para preparar y utilizar los comprimidos de capa doble.
MX2023005639A 2020-11-13 2021-11-02 Comprimidos de capa doble orales que comprenden acido acetilsalicilico y pseudoefedrina, metodos para preparar y utilizar los mismos. MX2023005639A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063113298P 2020-11-13 2020-11-13
PCT/US2021/057702 WO2022103620A1 (en) 2020-11-13 2021-11-02 Oral bilayer tablets comprising acetylsalicylic acid and pseudoephedrine, methods of preparing and using thereof

Publications (1)

Publication Number Publication Date
MX2023005639A true MX2023005639A (es) 2023-09-22

Family

ID=78771234

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023005639A MX2023005639A (es) 2020-11-13 2021-11-02 Comprimidos de capa doble orales que comprenden acido acetilsalicilico y pseudoefedrina, metodos para preparar y utilizar los mismos.

Country Status (5)

Country Link
US (2) US11857684B2 (es)
EP (1) EP4243781A1 (es)
CA (1) CA3201462A1 (es)
MX (1) MX2023005639A (es)
WO (1) WO2022103620A1 (es)

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB191225486A (en) 1912-11-06 1913-04-24 Herbert Sefton-Jones Manufacture and Production of Improved Pharmaceutical Preparations.
US2293359A (en) 1941-01-08 1942-08-18 Quisling Sverre Acetyl salicylic acid preparation
FI89004C (fi) 1988-02-16 1993-08-10 Pertti J Neuvonen Anvaendning av tillsatsmedel foer oekning av absorptionshastigheten av laekemedel i orala laekemedelspreparat
RU2099058C1 (ru) 1992-06-15 1997-12-20 Институт химии твердого тела и переработки минерального сырья СО РАН Способ получения твердой быстрорастворимой дисперсной системы, содержащей ацетилсалициловую кислоту
US5665388A (en) 1995-11-13 1997-09-09 Health Corporation Method for preparation of an alkaline and aspirin combination compound
WO1999009988A1 (en) 1997-08-27 1999-03-04 Hexal Ag New pharmaceutical compositions of meloxicam with improved solubility and bioavailability
US8231899B2 (en) 1998-09-10 2012-07-31 Nycomed Danmark Aps Quick release pharmaceutical compositions of drug substances
US20030180352A1 (en) 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
RU2170582C1 (ru) 2000-02-17 2001-07-20 Институт химии твердого тела и механохимии СО РАН Способ получения быстрорастворимой таблетированной формы ацетилсалициловой кислоты
US20020094345A1 (en) * 2000-10-06 2002-07-18 Sara Abelaira Pharmaceutical compositions containing epinastine and pseudoephedrine
EP1744757A4 (en) 2004-05-04 2009-04-22 Equitech Corp IMPROVED ENHANCED COMPOSITION
US8216610B2 (en) 2004-05-28 2012-07-10 Imaginot Pty Ltd. Oral paracetamol formulations
ES2450648T3 (es) 2004-06-29 2014-03-25 Takeda Pharma A/S Fabricación de composiciones farmacéuticas con liberación rápida de fármacos insolubles en agua y composiciones farmacéuticas obtenidas mediante el procedimiento de la invención
EP2417969A1 (en) 2004-10-21 2012-02-15 Aptalis Pharmatech, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
AU2006317530B2 (en) 2005-11-28 2011-09-01 Imaginot Pty Ltd Oral therapeutic compound delivery system
US11135188B2 (en) 2009-05-11 2021-10-05 Bayer Healthcare Llc Method and composition to improve absorption of therapeutic agents
US20130122098A1 (en) * 2011-11-14 2013-05-16 Bayer Healthcare Llc Method and composition to improve absorption of therapeutic agents
CN105579033A (zh) * 2013-09-27 2016-05-11 强生消费者公司 压制包衣的脉动释放组合物
US10576041B2 (en) * 2016-09-26 2020-03-03 The Procter & Gamble Company Extended relief dosage form

Also Published As

Publication number Publication date
US11857684B2 (en) 2024-01-02
CA3201462A1 (en) 2022-05-19
US20240091158A1 (en) 2024-03-21
WO2022103620A1 (en) 2022-05-19
EP4243781A1 (en) 2023-09-20
US20220151936A1 (en) 2022-05-19

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