MX2023001535A - Peptidomimeticos antimicrobianos. - Google Patents
Peptidomimeticos antimicrobianos.Info
- Publication number
- MX2023001535A MX2023001535A MX2023001535A MX2023001535A MX2023001535A MX 2023001535 A MX2023001535 A MX 2023001535A MX 2023001535 A MX2023001535 A MX 2023001535A MX 2023001535 A MX2023001535 A MX 2023001535A MX 2023001535 A MX2023001535 A MX 2023001535A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- peptidomimetics
- compounds
- directed
- bacterial infections
- Prior art date
Links
- 239000000816 peptidomimetic Substances 0.000 title abstract 6
- 230000000845 anti-microbial effect Effects 0.000 title abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 3
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 206010018910 Haemolysis Diseases 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000000249 desinfective effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 230000008588 hemolysis Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Insects & Arthropods (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención está dirigida a peptidomiméticos que tienen actividad antibacteriana, especialmente contra bacterias Gram negativas. Los peptidomiméticos de la invención son compuestos de la fórmula general (I), P1 -P2 -P3 -P4 -P5 -P6 -P7 -P8 -P9 -P10-P11-P12-P13-P14-P15-P16 (I) y sales farmacéuticamente aceptables de los mismos, como se describe en la descripción y en las reivindicaciones. La invención también está dirigida a usos terapéuticos de los peptidomiméticos para el tratamiento o prevención de infecciones bacterianas y enfermedades relacionadas con infecciones bacterianas y usos no terapéuticos de los peptidomiméticos para conservar o desinfectar alimentos, cosméticos, medicamentos u otros materiales que contienen nutrientes. Además, la presente invención proporciona un proceso de síntesis eficiente mediante el cual estos compuestos pueden, si se desea, prepararse en formato de biblioteca paralela. Además, los peptidomiméticos de la invención muestran actividad antimicrobiana mejorada, hemólisis baja o nula de glóbulos rojos y citotoxicidad reducida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020353 | 2020-08-05 | ||
| PCT/EP2021/025301 WO2022028737A1 (en) | 2020-08-05 | 2021-08-05 | Antimicrobial peptidomimetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023001535A true MX2023001535A (es) | 2023-05-03 |
Family
ID=71994280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023001535A MX2023001535A (es) | 2020-08-05 | 2021-08-05 | Peptidomimeticos antimicrobianos. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP4214220A1 (es) |
| JP (1) | JP2023553576A (es) |
| KR (1) | KR20230107204A (es) |
| CN (1) | CN115989236A (es) |
| AU (1) | AU2021323364A1 (es) |
| BR (1) | BR112023002060A2 (es) |
| CA (1) | CA3190694A1 (es) |
| IL (1) | IL300391A (es) |
| MX (1) | MX2023001535A (es) |
| TW (1) | TW202221009A (es) |
| WO (1) | WO2022028737A1 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101173005A (zh) * | 2007-10-30 | 2008-05-07 | 沈子龙 | 昆虫抗菌肽Thanatin衍生物及其制备方法与用途 |
| JP2011072294A (ja) * | 2009-10-02 | 2011-04-14 | Hokkaido Univ | 新規抗菌ペプチド |
-
2021
- 2021-08-05 AU AU2021323364A patent/AU2021323364A1/en active Pending
- 2021-08-05 TW TW110128989A patent/TW202221009A/zh unknown
- 2021-08-05 WO PCT/EP2021/025301 patent/WO2022028737A1/en active Application Filing
- 2021-08-05 CN CN202180053078.8A patent/CN115989236A/zh active Pending
- 2021-08-05 MX MX2023001535A patent/MX2023001535A/es unknown
- 2021-08-05 KR KR1020237007249A patent/KR20230107204A/ko unknown
- 2021-08-05 JP JP2023508095A patent/JP2023553576A/ja active Pending
- 2021-08-05 IL IL300391A patent/IL300391A/en unknown
- 2021-08-05 BR BR112023002060A patent/BR112023002060A2/pt unknown
- 2021-08-05 CA CA3190694A patent/CA3190694A1/en active Pending
- 2021-08-05 EP EP21762607.6A patent/EP4214220A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3190694A1 (en) | 2022-02-10 |
| EP4214220A1 (en) | 2023-07-26 |
| BR112023002060A2 (pt) | 2023-05-02 |
| US20240132553A1 (en) | 2024-04-25 |
| WO2022028737A1 (en) | 2022-02-10 |
| AU2021323364A1 (en) | 2023-03-30 |
| IL300391A (en) | 2023-04-01 |
| KR20230107204A (ko) | 2023-07-14 |
| TW202221009A (zh) | 2022-06-01 |
| CN115989236A (zh) | 2023-04-18 |
| JP2023553576A (ja) | 2023-12-25 |
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