WO2022114728A3 - Shmt 억제제 또는 mthfr 억제제를 포함하는 박테리아 감염 치료용 조성물 - Google Patents

Shmt 억제제 또는 mthfr 억제제를 포함하는 박테리아 감염 치료용 조성물 Download PDF

Info

Publication number
WO2022114728A3
WO2022114728A3 PCT/KR2021/017267 KR2021017267W WO2022114728A3 WO 2022114728 A3 WO2022114728 A3 WO 2022114728A3 KR 2021017267 W KR2021017267 W KR 2021017267W WO 2022114728 A3 WO2022114728 A3 WO 2022114728A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitor
shmt
mthfr
infection
antibiotics
Prior art date
Application number
PCT/KR2021/017267
Other languages
English (en)
French (fr)
Other versions
WO2022114728A2 (ko
Inventor
김경규
쿠마르 차우라시아아킬레시
나얍 바툴
호앙 안 응우옌
Original Assignee
성균관대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020210152353A external-priority patent/KR20220071901A/ko
Application filed by 성균관대학교산학협력단 filed Critical 성균관대학교산학협력단
Publication of WO2022114728A2 publication Critical patent/WO2022114728A2/ko
Publication of WO2022114728A3 publication Critical patent/WO2022114728A3/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명에 따른 SHMT 억제제 또는 MTHFR 억제제는 박테리아의 생장에는 영향을 미치지 않으면서 그람 양성 및 그람 음성 박테리아에 의한 감염을 억제할 수 있고, 다양한 항생제 및 리소스타핀에 대한 저항성을 억제할 수 있다. 또한, SHMT 억제제 또는 MTHFR 억제제는 숙주로의 박테리아 감염 치사율을 현저히 감소시킴에 따라, SHMT 또는 MTHFR 억제제가 다제내성 균주에 대한 잠재적 타겟이 될 수 있을 것으로 기대된다. 따라서, SHMT 또는 MTHFR 억제제를 박테리아 감염의 예방, 개선 또는 치료를 위한 의약품, 화장료 조성물, 건강식품, 동물용 사료, 식품 또는 사료 첨가제 등의 제조에 용이하게 사용될 수 있을 뿐만 아니라, 의료용기의 세척이나 나아가 항생제 내성을 가지거나 항생제 처리 시 독성을 가지는 박테리아의 억제용도로 유용하게 사용할 수 있을 것으로 기대된다.
PCT/KR2021/017267 2020-11-24 2021-11-23 Shmt 억제제 또는 mthfr 억제제를 포함하는 박테리아 감염 치료용 조성물 WO2022114728A2 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2020-0158625 2020-11-24
KR20200158625 2020-11-24
KR1020210152353A KR20220071901A (ko) 2020-11-24 2021-11-08 Shmt 억제제 또는 mthfr 억제제를 포함하는 박테리아 감염 치료용 조성물
KR10-2021-0152353 2021-11-08

Publications (2)

Publication Number Publication Date
WO2022114728A2 WO2022114728A2 (ko) 2022-06-02
WO2022114728A3 true WO2022114728A3 (ko) 2022-08-18

Family

ID=81756219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2021/017267 WO2022114728A2 (ko) 2020-11-24 2021-11-23 Shmt 억제제 또는 mthfr 억제제를 포함하는 박테리아 감염 치료용 조성물

Country Status (1)

Country Link
WO (1) WO2022114728A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115105490B (zh) * 2022-06-16 2024-01-30 青岛农业大学 一种抑制产气荚膜梭菌的植物精油组合物及应用
CN115105491B (zh) * 2022-07-08 2023-12-22 东北农业大学 丝氨酸在制备抑制猪链球菌药物中的用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002043741A2 (en) * 2000-12-01 2002-06-06 Mcgill University Methylenetetrahydrofolate reductase inhibitors and use thereof
US20030228650A1 (en) * 2002-05-17 2003-12-11 Amy Skalchunes Methods for the identification of inhibitors of Methylenetetrahydrofolate reductase as antibiotics
US20180072751A1 (en) * 2016-09-14 2018-03-15 The Trustees Of Princeton University SHMT Inhibitors
US20190345119A1 (en) * 2016-12-05 2019-11-14 Raze Therapeutics, Inc. Shmt inhibitors and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002043741A2 (en) * 2000-12-01 2002-06-06 Mcgill University Methylenetetrahydrofolate reductase inhibitors and use thereof
US20030228650A1 (en) * 2002-05-17 2003-12-11 Amy Skalchunes Methods for the identification of inhibitors of Methylenetetrahydrofolate reductase as antibiotics
US20180072751A1 (en) * 2016-09-14 2018-03-15 The Trustees Of Princeton University SHMT Inhibitors
US20190345119A1 (en) * 2016-12-05 2019-11-14 Raze Therapeutics, Inc. Shmt inhibitors and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BATOOL NAYAB, KO KWAN SOO, CHAURASIA AKHILESH KUMAR, KIM KYEONG KYU: "Functional Identification of Serine Hydroxymethyltransferase as a Key Gene Involved in Lysostaphin Resistance and Virulence Potential of Staphylococcus aureus Strains", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 23, 1 January 2020 (2020-01-01), pages 9135, XP055958225, DOI: 10.3390/ijms21239135 *
DUCKER GREGORY S., GHERGUROVICH JONATHAN M., MAINOLFI NELLO, SURI VIPIN, JEONG STEPHANIE K., HSIN-JUNG LI SOPHIA, FRIEDMAN ADAM, M: "Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 114, no. 43, 24 October 2017 (2017-10-24), pages 11404 - 11409, XP055780679, ISSN: 0027-8424, DOI: 10.1073/pnas.1706617114 *

Also Published As

Publication number Publication date
WO2022114728A2 (ko) 2022-06-02

Similar Documents

Publication Publication Date Title
WO2022114728A3 (ko) Shmt 억제제 또는 mthfr 억제제를 포함하는 박테리아 감염 치료용 조성물
Gibbons et al. The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet (K) determinant
WO2018208985A3 (en) Antibacterial compounds
WO2018208987A3 (en) Antibacterial compounds
WO2020061375A8 (en) Antibacterial compounds
PH12019500815A1 (en) Extract of an herbal composition as antimicrobial and/or antibiofilm agent
WO2016105510A3 (en) Methods and compositions for growth, storage, and use of bacterial preparations for wound and surface treatments
CN103549622A (zh) 一种协同抑制常见微生物的天然抑箘剂组合物
CN101568257A (zh) 抗菌剂及杀菌剂
JP2013170160A (ja) ペプチド含有抗菌性組成物
WO2020165057A8 (en) Compositions containing bacillaene producing bacteria or preparations thereof
Selim et al. Evolution of bactericidal activity of selected food additives against food borne microbial pathogens
Yim et al. Time-kill synergy tests of tigecycline combined with imipenem, amikacin, and ciprofloxacin against clinical isolates of multidrug-resistant Klebsiella pneumoniae and Escherichia coli
EP2993985A1 (en) Antimicrobial compositions containing carvacrol and thymol
CN110974838B (zh) 金化合物在制备抗菌剂中的应用
KR102051612B1 (ko) 비타민b₁라우릴황산염 및 중쇄지방산의 시너지 항균효과를 이용한 살균용 조성물
Jafarzadeh et al. In Vitro evaluation of the anti-bacterial effect of human platelet concentrate
CN106666104A (zh) 一种含肉桂醛和姜黄素的植物提取物饲料添加剂
MX2023001535A (es) Peptidomimeticos antimicrobianos.
KR20200082041A (ko) 로즈마리 추출물 및 아스코르브산류를 유효성분으로 함유하는 항균용 조성물
JP6441065B2 (ja) 抗菌活性増強剤
CA3081534A1 (en) Peptide nucleic acid molecules for treatment of gram positive bacterial infection
KR102630869B1 (ko) 황산수소나트륨 및 중쇄지방산을 포함하는 항균용 조성물, 이를 이용한 항균 방법 및 이를 포함한 항균제
FR2380277A1 (fr) L'antibiotique desacetyl, dihydro 890 a9
Rowsni et al. Antimicrobial activity of essential oils against food-borne pathogenic bacteria

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21898554

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21898554

Country of ref document: EP

Kind code of ref document: A2