MX2023000979A - Polimorfos de 5-aza-4'-tio-2'-desoxicitidina. - Google Patents
Polimorfos de 5-aza-4'-tio-2'-desoxicitidina.Info
- Publication number
- MX2023000979A MX2023000979A MX2023000979A MX2023000979A MX2023000979A MX 2023000979 A MX2023000979 A MX 2023000979A MX 2023000979 A MX2023000979 A MX 2023000979A MX 2023000979 A MX2023000979 A MX 2023000979A MX 2023000979 A MX2023000979 A MX 2023000979A
- Authority
- MX
- Mexico
- Prior art keywords
- deoxycytidine
- aza
- thio
- crystalline polymorphs
- intended
- Prior art date
Links
- HOOZQNOZVFCJNL-KVQBGUIXSA-N 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]-1,3,5-triazin-2-one Chemical compound O=C1N=C(N)N=CN1[C@@H]1S[C@H](CO)[C@@H](O)C1 HOOZQNOZVFCJNL-KVQBGUIXSA-N 0.000 abstract 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 201000005787 hematologic cancer Diseases 0.000 abstract 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063055754P | 2020-07-23 | 2020-07-23 | |
| PCT/US2021/043021 WO2022020747A1 (en) | 2020-07-23 | 2021-07-23 | Polymorophs of 5-aza-4'-thio-2-deoxycytidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023000979A true MX2023000979A (es) | 2023-04-20 |
Family
ID=79687860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023000979A MX2023000979A (es) | 2020-07-23 | 2021-07-23 | Polimorfos de 5-aza-4'-tio-2'-desoxicitidina. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11447472B2 (enExample) |
| EP (1) | EP4185583A4 (enExample) |
| JP (1) | JP7679452B2 (enExample) |
| KR (1) | KR102866823B1 (enExample) |
| CN (1) | CN115989229A (enExample) |
| AU (1) | AU2021314329A1 (enExample) |
| BR (1) | BR112023001236A2 (enExample) |
| CA (1) | CA3186696A1 (enExample) |
| MX (1) | MX2023000979A (enExample) |
| WO (1) | WO2022020747A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230123277A1 (en) * | 2021-10-15 | 2023-04-20 | Akirabio, Inc. | Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease and thalassemia |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020322A (en) | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| US5591722A (en) * | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
| US20060014949A1 (en) | 2004-07-13 | 2006-01-19 | Supergen Inc. | Compositions and formulations of decitabine polymorphs and methods of use thereof |
| CN103951583B (zh) | 2006-12-06 | 2016-01-06 | 科内图斯医药公司 | 一种抑制剂的结晶形式 |
| DK3782612T3 (da) | 2008-05-15 | 2024-01-15 | Celgene Corp | Orale formuleringer af cytidinanaloger og fremgangsmåder til anvendelse deraf |
| WO2011109012A1 (en) | 2010-03-02 | 2011-09-09 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| US20110218170A1 (en) | 2010-03-02 | 2011-09-08 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| CN106687139A (zh) | 2014-07-14 | 2017-05-17 | 吉利德科学公司 | 用于治疗癌症的组合 |
| US20160312261A1 (en) | 2015-04-24 | 2016-10-27 | Plasmia Biotech, S.L. | Enzymatic production of cytosinic nucleoside analogues |
| US20190240210A1 (en) | 2016-10-17 | 2019-08-08 | Daiichi Sankyo Company, Limited | Treatment Method by Combined Use of MDM2 Inhibitor and DNA Methyltransferase Inhibitor |
| JP7425734B2 (ja) * | 2018-02-01 | 2024-01-31 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ２’－デオキシヌクレオシドを製造するための立体選択的合成およびプロセス |
| US20210363170A1 (en) | 2018-04-19 | 2021-11-25 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
-
2021
- 2021-07-23 BR BR112023001236A patent/BR112023001236A2/pt unknown
- 2021-07-23 MX MX2023000979A patent/MX2023000979A/es unknown
- 2021-07-23 CA CA3186696A patent/CA3186696A1/en active Pending
- 2021-07-23 CN CN202180052138.4A patent/CN115989229A/zh active Pending
- 2021-07-23 US US17/384,345 patent/US11447472B2/en active Active
- 2021-07-23 JP JP2023504527A patent/JP7679452B2/ja active Active
- 2021-07-23 AU AU2021314329A patent/AU2021314329A1/en active Pending
- 2021-07-23 KR KR1020237006092A patent/KR102866823B1/ko active Active
- 2021-07-23 EP EP21845710.9A patent/EP4185583A4/en active Pending
- 2021-07-23 WO PCT/US2021/043021 patent/WO2022020747A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022020747A8 (en) | 2023-02-16 |
| BR112023001236A2 (pt) | 2023-04-04 |
| US11447472B2 (en) | 2022-09-20 |
| US20220024903A1 (en) | 2022-01-27 |
| EP4185583A4 (en) | 2024-10-30 |
| EP4185583A1 (en) | 2023-05-31 |
| AU2021314329A1 (en) | 2023-02-23 |
| AU2021314329A8 (en) | 2023-03-09 |
| WO2022020747A1 (en) | 2022-01-27 |
| JP2023535724A (ja) | 2023-08-21 |
| KR102866823B1 (ko) | 2025-09-30 |
| JP7679452B2 (ja) | 2025-05-19 |
| CA3186696A1 (en) | 2022-01-27 |
| KR20230061354A (ko) | 2023-05-08 |
| CN115989229A (zh) | 2023-04-18 |
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