JP7679452B2 - ５－アザ－４’－チオ－２’－デオキシシチジンの多形 - Google Patents

５－アザ－４’－チオ－２’－デオキシシチジンの多形 Download PDF

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JP7679452B2
JP7679452B2 JP2023504527A JP2023504527A JP7679452B2 JP 7679452 B2 JP7679452 B2 JP 7679452B2 JP 2023504527 A JP2023504527 A JP 2023504527A JP 2023504527 A JP2023504527 A JP 2023504527A JP 7679452 B2 JP7679452 B2 JP 7679452B2
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cancer
aza
dcyd
crystalline form
crystalline
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JP2023535724A (ja
JP2023535724A5 (enExample
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マーク ジェイ スト
ドゥ ヨン チョン
ジン ス リ
ヒョニョン チョ
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サウザーン リサーチ インスチチュート
ピノットバイオ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023504527A 2020-07-23 2021-07-23 ５－アザ－４’－チオ－２’－デオキシシチジンの多形 Active JP7679452B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063055754P 2020-07-23 2020-07-23
US63/055,754 2020-07-23
PCT/US2021/043021 WO2022020747A1 (en) 2020-07-23 2021-07-23 Polymorophs of 5-aza-4'-thio-2-deoxycytidine

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JP2023535724A JP2023535724A (ja) 2023-08-21
JP2023535724A5 JP2023535724A5 (enExample) 2024-07-31
JP7679452B2 true JP7679452B2 (ja) 2025-05-19

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JP2023504527A Active JP7679452B2 (ja) 2020-07-23 2021-07-23 ５－アザ－４’－チオ－２’－デオキシシチジンの多形

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US (1) US11447472B2 (enExample)
EP (1) EP4185583A4 (enExample)
JP (1) JP7679452B2 (enExample)
KR (1) KR102866823B1 (enExample)
CN (1) CN115989229A (enExample)
AU (1) AU2021314329A1 (enExample)
BR (1) BR112023001236A2 (enExample)
CA (1) CA3186696A1 (enExample)
MX (1) MX2023000979A (enExample)
WO (1) WO2022020747A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230123277A1 (en) * 2021-10-15 2023-04-20 Akirabio, Inc. Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease and thalassemia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010511689A (ja) 2006-12-06 2010-04-15 ファイザー・インク （３Ｓ）−３−［Ｎ−（Ｎ’−（２−ｔｅｒｔ−ブチルフェニル）オキサミル）アラニニル］アミノ−５−（２’，３’，５’，６’−テトラフルオロフェノキシ）−４−オキソペンタン酸の結晶形態
WO2019152459A1 (en) 2018-02-01 2019-08-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Stereoselective synthesis and process for the manufacturing of 2'-deoxynucleosides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020322A (en) 1993-11-09 2000-02-01 Pro-Neuron, Inc. Acyl deoxyribonucleoside derivatives and uses thereof
US5591722A (en) 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
US20060014949A1 (en) * 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
PL3692983T3 (pl) 2008-05-15 2021-12-27 Celgene Corporation Doustne formulacje analogów cytydyny i sposoby ich zastosowania
WO2011109012A1 (en) 2010-03-02 2011-09-09 Southern Research Institute Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
US20110218170A1 (en) 2010-03-02 2011-09-08 Southern Research Institute Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
SG11201610551TA (en) 2014-07-14 2017-01-27 Gilead Sciences Inc Combinations for treating cancers
US20160312261A1 (en) 2015-04-24 2016-10-27 Plasmia Biotech, S.L. Enzymatic production of cytosinic nucleoside analogues
EP3527226A4 (en) 2016-10-17 2020-06-17 Daiichi Sankyo Company, Limited COMBINATION THERAPY PROCEDURE WITH MDM2 INHIBITOR AND DNA METHYL TRANSFERASE INHIBITOR
WO2019204637A1 (en) * 2018-04-19 2019-10-24 Southern Research Institute 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010511689A (ja) 2006-12-06 2010-04-15 ファイザー・インク （３Ｓ）−３−［Ｎ−（Ｎ’−（２−ｔｅｒｔ−ブチルフェニル）オキサミル）アラニニル］アミノ−５−（２’，３’，５’，６’−テトラフルオロフェノキシ）−４−オキソペンタン酸の結晶形態
WO2019152459A1 (en) 2018-02-01 2019-08-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Stereoselective synthesis and process for the manufacturing of 2'-deoxynucleosides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Nucleosides and Nucleotides，1995年，Vol. 14, No. 3-5，p. 675-686
Nucleosides and Nucleotides，1999年，Vol. 18, No. 4-5，p. 613-614
平山令明，有機化合物結晶作製ハンドブック，丸善株式会社，2008年，pp. 17-23,37-40,45-51,57-65，ISBN 978-4-621-07991-1

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MX2023000979A (es) 2023-04-20
EP4185583A4 (en) 2024-10-30
CA3186696A1 (en) 2022-01-27
KR102866823B1 (ko) 2025-09-30
EP4185583A1 (en) 2023-05-31
WO2022020747A1 (en) 2022-01-27
US11447472B2 (en) 2022-09-20
AU2021314329A1 (en) 2023-02-23
AU2021314329A8 (en) 2023-03-09
JP2023535724A (ja) 2023-08-21
KR20230061354A (ko) 2023-05-08
WO2022020747A8 (en) 2023-02-16
BR112023001236A2 (pt) 2023-04-04
US20220024903A1 (en) 2022-01-27
CN115989229A (zh) 2023-04-18

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