MX2022015742A - Formas farmaceuticas osmoticas que comprenden deutetrabenazina y metodos de uso de las mismas. - Google Patents
Formas farmaceuticas osmoticas que comprenden deutetrabenazina y metodos de uso de las mismas.Info
- Publication number
- MX2022015742A MX2022015742A MX2022015742A MX2022015742A MX2022015742A MX 2022015742 A MX2022015742 A MX 2022015742A MX 2022015742 A MX2022015742 A MX 2022015742A MX 2022015742 A MX2022015742 A MX 2022015742A MX 2022015742 A MX2022015742 A MX 2022015742A
- Authority
- MX
- Mexico
- Prior art keywords
- dosage forms
- deutetrabenazine
- osmotic dosage
- methods
- treatment
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 title abstract 3
- MKJIEFSOBYUXJB-VFJJUKLQSA-N (3r,11br)-3-(2-methylpropyl)-9,10-bis(trideuteriomethoxy)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one Chemical compound C1CN2C[C@@H](CC(C)C)C(=O)C[C@@H]2C2=C1C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C2 MKJIEFSOBYUXJB-VFJJUKLQSA-N 0.000 title abstract 2
- 229950005031 deutetrabenazine Drugs 0.000 title abstract 2
- 230000003204 osmotic effect Effects 0.000 title abstract 2
- 208000000269 Hyperkinesis Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4747—Quinolines; Isoquinolines spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Inorganic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Se proporcionan en el presente documento formas farmacéuticas osmóticas que contienen deutetrabenazina para su uso en el tratamiento de, por ejemplo, trastornos de movimiento hipercinéticos. Cuando se administran por vía oral a un sujeto diariamente una vez al día, las formas farmacéuticas proporcionan un perfil farmacocinético favorable para el principio activo indicando una eficacia del tratamiento durante un periodo extendido de tiempo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063037369P | 2020-06-10 | 2020-06-10 | |
US202063037953P | 2020-06-11 | 2020-06-11 | |
US202063044451P | 2020-06-26 | 2020-06-26 | |
PCT/US2021/036778 WO2021252741A1 (en) | 2020-06-10 | 2021-06-10 | Osmotic dosage forms comprising deutetrabenazine and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022015742A true MX2022015742A (es) | 2023-01-19 |
Family
ID=78826343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022015742A MX2022015742A (es) | 2020-06-10 | 2021-06-10 | Formas farmaceuticas osmoticas que comprenden deutetrabenazina y metodos de uso de las mismas. |
Country Status (20)
Country | Link |
---|---|
US (2) | US11311488B2 (es) |
EP (2) | EP4153136B1 (es) |
JP (2) | JP7419571B2 (es) |
KR (2) | KR102638424B1 (es) |
CN (1) | CN115916154A (es) |
AU (2) | AU2021288087B2 (es) |
BR (1) | BR112022025185B1 (es) |
CA (1) | CA3186425A1 (es) |
CL (1) | CL2022003512A1 (es) |
DK (1) | DK4153136T3 (es) |
FI (1) | FI4153136T3 (es) |
HR (1) | HRP20240303T1 (es) |
IL (1) | IL298629A (es) |
LT (1) | LT4153136T (es) |
MX (1) | MX2022015742A (es) |
PE (1) | PE20230852A1 (es) |
PT (1) | PT4153136T (es) |
RS (1) | RS65328B1 (es) |
TW (1) | TW202214246A (es) |
WO (1) | WO2021252741A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023240186A1 (en) * | 2022-06-08 | 2023-12-14 | Auspex Pharmaceuticals, Inc. | Osmotic dosage forms comprising deutetrabenazine and methods of use thereof |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3173876A (en) | 1960-05-27 | 1965-03-16 | John C Zobrist | Cleaning methods and compositions |
US3276586A (en) | 1963-08-30 | 1966-10-04 | Rosaen Filter Co | Indicating means for fluid filters |
US3546142A (en) | 1967-01-19 | 1970-12-08 | Amicon Corp | Polyelectrolyte structures |
US3541006A (en) | 1968-07-03 | 1970-11-17 | Amicon Corp | Ultrafiltration process |
US3541005A (en) | 1969-02-05 | 1970-11-17 | Amicon Corp | Continuous ultrafiltration of macromolecular solutions |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
GB1478759A (en) | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
US4200098A (en) | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
US5082668A (en) | 1983-05-11 | 1992-01-21 | Alza Corporation | Controlled-release system with constant pushing source |
US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
US20030161882A1 (en) * | 2002-02-01 | 2003-08-28 | Waterman Kenneth C. | Osmotic delivery system |
US20070031496A1 (en) * | 2005-08-04 | 2007-02-08 | Edgren David E | Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties |
US20120208773A1 (en) * | 2008-08-12 | 2012-08-16 | Valeant International (Barbados) Srl | Pharmaceutical compositions with tetrabenazine |
ES2425623T3 (es) | 2008-09-18 | 2013-10-16 | Auspex Pharmaceuticals, Inc. | Inhibidores benzoquinolínicos de transportador vesicular de monoaminas 2 |
JP2013501810A (ja) * | 2009-08-12 | 2013-01-17 | ヴァリーント インターナショナル(バルバドス)エスアールエル | 医薬組成物 |
CN111728971A (zh) * | 2012-09-18 | 2020-10-02 | 奥斯拜客斯制药有限公司 | D6-四苯喹嗪固体口服剂型、化合物、及其药物组合物、制备及治疗方法 |
US10479787B2 (en) * | 2016-04-22 | 2019-11-19 | Lupin Limited | Process for preparation of tetrabenazine and deutetrabenazine |
US20170312226A1 (en) * | 2016-04-28 | 2017-11-02 | Ascent Pharmaceuticals, Inc. | Pharmaceutical dosage forms |
US11813232B2 (en) * | 2017-03-15 | 2023-11-14 | Auspex Pharmaceuticals, Inc. | Analogs of deutetrabenazine, their preparation and use |
CA3104693A1 (en) * | 2018-08-15 | 2020-02-20 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
-
2021
- 2021-06-10 FI FIEP21737870.2T patent/FI4153136T3/fi active
- 2021-06-10 DK DK21737870.2T patent/DK4153136T3/da active
- 2021-06-10 EP EP21737870.2A patent/EP4153136B1/en active Active
- 2021-06-10 EP EP23219522.2A patent/EP4364738A2/en active Pending
- 2021-06-10 HR HRP20240303TT patent/HRP20240303T1/hr unknown
- 2021-06-10 RS RS20240332A patent/RS65328B1/sr unknown
- 2021-06-10 KR KR1020237000961A patent/KR102638424B1/ko active IP Right Grant
- 2021-06-10 KR KR1020247005191A patent/KR20240025706A/ko active Search and Examination
- 2021-06-10 WO PCT/US2021/036778 patent/WO2021252741A1/en active Application Filing
- 2021-06-10 BR BR112022025185-8A patent/BR112022025185B1/pt active IP Right Grant
- 2021-06-10 LT LTEPPCT/US2021/036778T patent/LT4153136T/lt unknown
- 2021-06-10 PT PT217378702T patent/PT4153136T/pt unknown
- 2021-06-10 JP JP2022576176A patent/JP7419571B2/ja active Active
- 2021-06-10 AU AU2021288087A patent/AU2021288087B2/en active Active
- 2021-06-10 US US17/344,271 patent/US11311488B2/en active Active
- 2021-06-10 CN CN202180042147.5A patent/CN115916154A/zh active Pending
- 2021-06-10 IL IL298629A patent/IL298629A/en unknown
- 2021-06-10 PE PE2022002886A patent/PE20230852A1/es unknown
- 2021-06-10 TW TW110121253A patent/TW202214246A/zh unknown
- 2021-06-10 MX MX2022015742A patent/MX2022015742A/es unknown
- 2021-06-10 CA CA3186425A patent/CA3186425A1/en active Pending
-
2022
- 2022-03-01 US US17/683,732 patent/US20230022862A1/en active Pending
- 2022-12-09 CL CL2022003512A patent/CL2022003512A1/es unknown
-
2023
- 2023-06-27 AU AU2023204103A patent/AU2023204103A1/en active Pending
-
2024
- 2024-01-10 JP JP2024001864A patent/JP2024058686A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2021288087B2 (en) | 2023-03-30 |
PE20230852A1 (es) | 2023-05-29 |
BR112022025185B1 (pt) | 2023-10-24 |
PT4153136T (pt) | 2024-03-22 |
TW202214246A (zh) | 2022-04-16 |
US11311488B2 (en) | 2022-04-26 |
WO2021252741A1 (en) | 2021-12-16 |
JP2024058686A (ja) | 2024-04-26 |
CN115916154A (zh) | 2023-04-04 |
US20210386673A1 (en) | 2021-12-16 |
JP7419571B2 (ja) | 2024-01-22 |
AU2021288087A1 (en) | 2023-01-19 |
US20230022862A1 (en) | 2023-01-26 |
BR112022025185A2 (pt) | 2022-12-27 |
CA3186425A1 (en) | 2021-12-16 |
KR102638424B1 (ko) | 2024-02-19 |
LT4153136T (lt) | 2024-03-25 |
KR20240025706A (ko) | 2024-02-27 |
CL2022003512A1 (es) | 2023-07-28 |
FI4153136T3 (fi) | 2024-03-19 |
RS65328B1 (sr) | 2024-04-30 |
JP2023523092A (ja) | 2023-06-01 |
EP4153136A1 (en) | 2023-03-29 |
EP4364738A2 (en) | 2024-05-08 |
IL298629A (en) | 2023-01-01 |
AU2023204103A1 (en) | 2023-07-13 |
KR20230016703A (ko) | 2023-02-02 |
DK4153136T3 (da) | 2024-03-25 |
HRP20240303T1 (hr) | 2024-05-10 |
EP4153136B1 (en) | 2024-01-10 |
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