MX2022015524A - Formas cristalinas del acido {2-[3-ciclohexil-3-(trans-4-propoxi-c iclohexil)-ureido]-tiazol-5-ilsulfanil}-acetico y uso de las mismas. - Google Patents
Formas cristalinas del acido {2-[3-ciclohexil-3-(trans-4-propoxi-c iclohexil)-ureido]-tiazol-5-ilsulfanil}-acetico y uso de las mismas.Info
- Publication number
- MX2022015524A MX2022015524A MX2022015524A MX2022015524A MX2022015524A MX 2022015524 A MX2022015524 A MX 2022015524A MX 2022015524 A MX2022015524 A MX 2022015524A MX 2022015524 A MX2022015524 A MX 2022015524A MX 2022015524 A MX2022015524 A MX 2022015524A
- Authority
- MX
- Mexico
- Prior art keywords
- cyclohexyl
- crystalline forms
- ylsulfanyl
- ureido
- thiazol
- Prior art date
Links
- HPGJSAAUJGAMLV-UHFFFAOYSA-N 2-[[2-[[cyclohexyl-(4-propoxycyclohexyl)carbamoyl]amino]-1,3-thiazol-5-yl]sulfanyl]acetic acid Chemical compound C1CC(OCCC)CCC1N(C(=O)NC=1SC(SCC(O)=O)=CN=1)C1CCCCC1 HPGJSAAUJGAMLV-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
La presente descripción se refiere a a) formas cristalinas de ácido {2-[3-ciclohexil-3-(trans-4- propoxi-ciclohexil)-ureido]-tia zol-5-ilsulfanil}-acético ("Compuesto I "); b) composiciones farmacéuticas, que comprenden una o más formas cristalinas del Compuesto I y, opcionalmente, un portador farmacéuticamente aceptable; c) métodos para tratar un tipo de diabetes mellitus u otros trastornos mediante la administración de una o más formas cristalinas del Compuesto I; y d) métodos para la preparación de formas cristalinas del Compuesto I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063035994P | 2020-06-08 | 2020-06-08 | |
PCT/US2021/036082 WO2021252309A1 (en) | 2020-06-08 | 2021-06-07 | Crystalline forms of {2-[3-cyclohexyl-3-(trans-4-propoxy- cyclohexyl)-ureido]-thiazol-5-ylsulfanyl} -acetic acid and and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022015524A true MX2022015524A (es) | 2023-03-22 |
Family
ID=78846441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022015524A MX2022015524A (es) | 2020-06-08 | 2021-06-07 | Formas cristalinas del acido {2-[3-ciclohexil-3-(trans-4-propoxi-c iclohexil)-ureido]-tiazol-5-ilsulfanil}-acetico y uso de las mismas. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20230219910A1 (es) |
EP (1) | EP4161639A4 (es) |
JP (1) | JP2023530785A (es) |
KR (1) | KR20230048501A (es) |
CN (1) | CN116056760A (es) |
AU (1) | AU2021289591A1 (es) |
CA (1) | CA3181665A1 (es) |
MX (1) | MX2022015524A (es) |
WO (1) | WO2021252309A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105188676A (zh) * | 2013-03-04 | 2015-12-23 | Vtv治疗有限责任公司 | 包括葡糖激酶活化剂的固体组合物及其制备和使用方法 |
CN112040945A (zh) | 2018-06-12 | 2020-12-04 | Vtv治疗有限责任公司 | 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA06007667A (es) * | 2004-01-06 | 2006-09-01 | Novo Nordisk As | Heteroaril-ureas y su uso como activadores de glucocinasa. |
CA2799591C (en) * | 2010-05-26 | 2019-06-11 | Transtech Pharma, Inc. | Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator |
KR102371364B1 (ko) * | 2012-05-17 | 2022-03-07 | 브이티브이 테라퓨틱스 엘엘씨 | 당뇨병 치료를 위한 글루코키나아제 활성화제 조성물 |
CN105188676A (zh) * | 2013-03-04 | 2015-12-23 | Vtv治疗有限责任公司 | 包括葡糖激酶活化剂的固体组合物及其制备和使用方法 |
MX2015011109A (es) * | 2013-03-04 | 2015-11-16 | Vtv Therapeutics Llc | Composiciones estables de activador de glucoquinasa. |
CA3046861A1 (en) * | 2016-12-15 | 2018-06-21 | Hua Medicine (Shanghai) Ltd. | Oral preparation of glucokinase activator and preparation method therefor |
-
2021
- 2021-06-07 CN CN202180056233.1A patent/CN116056760A/zh active Pending
- 2021-06-07 KR KR1020237000609A patent/KR20230048501A/ko active Search and Examination
- 2021-06-07 US US18/000,908 patent/US20230219910A1/en active Pending
- 2021-06-07 CA CA3181665A patent/CA3181665A1/en active Pending
- 2021-06-07 JP JP2023519156A patent/JP2023530785A/ja active Pending
- 2021-06-07 EP EP21821691.9A patent/EP4161639A4/en active Pending
- 2021-06-07 MX MX2022015524A patent/MX2022015524A/es unknown
- 2021-06-07 AU AU2021289591A patent/AU2021289591A1/en active Pending
- 2021-06-07 WO PCT/US2021/036082 patent/WO2021252309A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021252309A1 (en) | 2021-12-16 |
US20230219910A1 (en) | 2023-07-13 |
JP2023530785A (ja) | 2023-07-19 |
CA3181665A1 (en) | 2021-12-16 |
CN116056760A (zh) | 2023-05-02 |
EP4161639A4 (en) | 2024-01-17 |
EP4161639A1 (en) | 2023-04-12 |
AU2021289591A1 (en) | 2023-01-19 |
KR20230048501A (ko) | 2023-04-11 |
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