MX2022014902A - Administracion mitigadora de efectos adversos de un constructo biespecifico que se une a cd33 y cd3. - Google Patents

Administracion mitigadora de efectos adversos de un constructo biespecifico que se une a cd33 y cd3.

Info

Publication number
MX2022014902A
MX2022014902A MX2022014902A MX2022014902A MX2022014902A MX 2022014902 A MX2022014902 A MX 2022014902A MX 2022014902 A MX2022014902 A MX 2022014902A MX 2022014902 A MX2022014902 A MX 2022014902A MX 2022014902 A MX2022014902 A MX 2022014902A
Authority
MX
Mexico
Prior art keywords
administration
treatment
construct
mitigating
adverse effects
Prior art date
Application number
MX2022014902A
Other languages
English (en)
Inventor
Dirk Nagorsen
Sophia K Khaldoyanidi
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2022014902A publication Critical patent/MX2022014902A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona un constructo biespecífico que comprende un primer dominio de unión que se une específicamente a una diana tal como CD33 y un segundo dominio de unión que se une específicamente a un efector tal como CD3, para su uso en un método para el tratamiento de la leucemia mieloide, donde el constructo se administra en uno o más ciclos de tratamiento de más de 14 días aplicando una dosificación escalonada que comprende al menos dos, preferentemente etapas, donde la primera etapa es mayor que la segundo etapa con respecto a la dosis anterior, y donde la segundo etapa es mayor que el opcional pero se prefiere una tercera etapa con respecto a la dosis anterior, un ciclo de tratamiento seguido opcionalmente por un período sin administración del constructo. Además, la invención proporciona un método para el tratamiento de la leucemia mieloide que comprende la administración de una cantidad terapéuticamente eficaz de tal constructo biespecífico y el uso de tal constructo biespecífico para la preparación de una composición farmacéutica para el tratamiento de leucemia mieloide.
MX2022014902A 2020-05-29 2021-05-31 Administracion mitigadora de efectos adversos de un constructo biespecifico que se une a cd33 y cd3. MX2022014902A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063032302P 2020-05-29 2020-05-29
US202063044833P 2020-06-26 2020-06-26
PCT/US2021/035069 WO2021243320A2 (en) 2020-05-29 2021-05-31 Adverse effects-mitigating administration of a bispecific antibody construct binding to cd33 and cd3

Publications (1)

Publication Number Publication Date
MX2022014902A true MX2022014902A (es) 2023-01-04

Family

ID=76601814

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022014902A MX2022014902A (es) 2020-05-29 2021-05-31 Administracion mitigadora de efectos adversos de un constructo biespecifico que se une a cd33 y cd3.

Country Status (8)

Country Link
US (1) US20240209085A1 (es)
EP (1) EP4157874A2 (es)
JP (1) JP2023527972A (es)
AU (1) AU2021281554A1 (es)
CA (1) CA3183693A1 (es)
MX (1) MX2022014902A (es)
TW (1) TW202210101A (es)
WO (1) WO2021243320A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024208836A1 (en) * 2023-04-03 2024-10-10 Universität Basel Discernible cell surface protein variants of cd33 for use in cell therapy

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Also Published As

Publication number Publication date
US20240209085A1 (en) 2024-06-27
CA3183693A1 (en) 2021-12-02
WO2021243320A2 (en) 2021-12-02
JP2023527972A (ja) 2023-07-03
TW202210101A (zh) 2022-03-16
WO2021243320A3 (en) 2022-02-17
AU2021281554A1 (en) 2022-12-15
EP4157874A2 (en) 2023-04-05

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