MX2022014168A - Sal y formas de cristal de 4-amino-5-(6-(4-metilpiperazin-1-il)-ih benzo[d]imidazol-2-il)tieno[2,3-b]piridin-6(7h)-ona. - Google Patents

Sal y formas de cristal de 4-amino-5-(6-(4-metilpiperazin-1-il)-ih benzo[d]imidazol-2-il)tieno[2,3-b]piridin-6(7h)-ona.

Info

Publication number
MX2022014168A
MX2022014168A MX2022014168A MX2022014168A MX2022014168A MX 2022014168 A MX2022014168 A MX 2022014168A MX 2022014168 A MX2022014168 A MX 2022014168A MX 2022014168 A MX2022014168 A MX 2022014168A MX 2022014168 A MX2022014168 A MX 2022014168A
Authority
MX
Mexico
Prior art keywords
salt
methylpiperazin
thieno
imidazol
pyridin
Prior art date
Application number
MX2022014168A
Other languages
English (en)
Inventor
Mark R Bray
Sze- Wan Li
Original Assignee
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network filed Critical Univ Health Network
Publication of MX2022014168A publication Critical patent/MX2022014168A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Se describe una forma de sal novedosa del Compuesto (I) representado por la siguiente fórmula estructural y sus correspondientes composiciones farmacéuticas, N H S O NH2 N H N N N (I), formas cristalinas individuales particulares de la sal tartrato del Compuesto (I) 1:1 son caracterizadas por una variedad de propiedades y mediciones físicas; también se describen métodos para preparar formas cristalinas específicas; la presente descripción también proporciona métodos para tratar cáncer en un sujeto.
MX2022014168A 2020-05-11 2021-05-10 Sal y formas de cristal de 4-amino-5-(6-(4-metilpiperazin-1-il)-ih benzo[d]imidazol-2-il)tieno[2,3-b]piridin-6(7h)-ona. MX2022014168A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063022867P 2020-05-11 2020-05-11
PCT/CA2021/050645 WO2021226707A1 (en) 2020-05-11 2021-05-10 Salt and crystal forms of 4-amino-5-(6-(4-methylpiperazin-1-yl)-1h-benzo[d]imidazol-2-yl)thieno[2,3-b]pyridin-6(7h)-one

Publications (1)

Publication Number Publication Date
MX2022014168A true MX2022014168A (es) 2023-02-22

Family

ID=78525916

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022014168A MX2022014168A (es) 2020-05-11 2021-05-10 Sal y formas de cristal de 4-amino-5-(6-(4-metilpiperazin-1-il)-ih benzo[d]imidazol-2-il)tieno[2,3-b]piridin-6(7h)-ona.

Country Status (12)

Country Link
US (1) US20230174549A1 (es)
EP (1) EP4149946A1 (es)
JP (1) JP2023526054A (es)
KR (1) KR20230019110A (es)
CN (1) CN115803330A (es)
AU (1) AU2021272064A1 (es)
BR (1) BR112022022946A2 (es)
CA (1) CA3178415A1 (es)
IL (1) IL298132A (es)
MX (1) MX2022014168A (es)
TW (1) TW202208375A (es)
WO (1) WO2021226707A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3873608A1 (en) 2018-10-31 2021-09-08 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
CA3117556A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
TWI826690B (zh) 2019-05-23 2023-12-21 美商基利科學股份有限公司 經取代之烯吲哚酮化物及其用途
US20240002394A1 (en) * 2020-11-24 2024-01-04 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Deuterium-modified thienopyridone compound
TW202333712A (zh) * 2021-12-22 2023-09-01 加拿大健康網路大學 於急性骨髓性白血病或淋巴瘤之治療
WO2023143384A1 (zh) * 2022-01-27 2023-08-03 四川海思科制药有限公司 一种抑制或降解hpk1激酶的化合物及其在医药中的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3322711B1 (en) * 2015-06-25 2021-03-10 University Health Network Hpk1 inhibitors and methods of using same
CN109721620B (zh) * 2017-10-27 2022-05-13 药捷安康(南京)科技股份有限公司 Hpk1抑制剂及其用途

Also Published As

Publication number Publication date
IL298132A (en) 2023-01-01
BR112022022946A2 (pt) 2023-01-10
EP4149946A1 (en) 2023-03-22
WO2021226707A1 (en) 2021-11-18
US20230174549A1 (en) 2023-06-08
JP2023526054A (ja) 2023-06-20
KR20230019110A (ko) 2023-02-07
AU2021272064A1 (en) 2023-01-19
CA3178415A1 (en) 2021-11-18
TW202208375A (zh) 2022-03-01
CN115803330A (zh) 2023-03-14

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