MX2022013207A - Metodos y composiciones para el tratamiento de cancer. - Google Patents
Metodos y composiciones para el tratamiento de cancer.Info
- Publication number
- MX2022013207A MX2022013207A MX2022013207A MX2022013207A MX2022013207A MX 2022013207 A MX2022013207 A MX 2022013207A MX 2022013207 A MX2022013207 A MX 2022013207A MX 2022013207 A MX2022013207 A MX 2022013207A MX 2022013207 A MX2022013207 A MX 2022013207A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compositions
- treating cancer
- chimeric binding
- same
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 239000011230 binding agent Substances 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4614—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a agentes aglutinantes quiméricos y composiciones que los comprenden. La invención se refiere además a los polinucleótidos que codifican el agente de unión quimérico y los vectores y las células huésped que los comprenden. La invención se refiere además a métodos de uso de agentes de unión quiméricos para mediar en la citotoxicidad celular dependiente de anticuerpos de células cancerosas epiteliales y métodos de tratamiento de cánceres de células epiteliales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063014550P | 2020-04-23 | 2020-04-23 | |
PCT/US2021/028775 WO2021216956A1 (en) | 2020-04-23 | 2021-04-23 | Compositions and methods for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022013207A true MX2022013207A (es) | 2023-01-24 |
Family
ID=78270118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022013207A MX2022013207A (es) | 2020-04-23 | 2021-04-23 | Metodos y composiciones para el tratamiento de cancer. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230140868A1 (es) |
EP (1) | EP4110822A4 (es) |
JP (1) | JP2023523016A (es) |
KR (1) | KR20230019424A (es) |
CN (1) | CN115485301A (es) |
AU (1) | AU2021261003A1 (es) |
BR (1) | BR112022019939A2 (es) |
CA (1) | CA3172092A1 (es) |
IL (1) | IL296576A (es) |
MX (1) | MX2022013207A (es) |
WO (1) | WO2021216956A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102423686B1 (ko) * | 2019-01-10 | 2022-07-21 | 에스지메디칼 주식회사 | 항 베타 1 인테그린 인간화 항체 및 이를 포함하는 암치료용 약학 조성물 |
WO2023056326A1 (en) * | 2021-09-30 | 2023-04-06 | Alpha Beta Holdings, Llc | Compositions and methods for treating cancer |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69828154T2 (de) * | 1997-03-12 | 2005-06-23 | Smithkline Beecham Corp. | Anti-alphavbeta3 humanizierte monoklonale antikörper |
CA2577329A1 (en) * | 2004-08-16 | 2006-03-02 | Medimmune, Inc. | Eph receptor fc variants with enhanced antibody dependent cell-mediated cytotoxicity activity |
JP2020512978A (ja) * | 2017-03-31 | 2020-04-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | アルファ−V ベータ−3(αvβ3)陽性がん幹細胞(CSCS)を処置および殺滅するためならびに薬物耐性がんを処置するための組成物および方法 |
-
2021
- 2021-04-23 CA CA3172092A patent/CA3172092A1/en active Pending
- 2021-04-23 WO PCT/US2021/028775 patent/WO2021216956A1/en unknown
- 2021-04-23 IL IL296576A patent/IL296576A/en unknown
- 2021-04-23 KR KR1020227040872A patent/KR20230019424A/ko unknown
- 2021-04-23 CN CN202180031794.6A patent/CN115485301A/zh active Pending
- 2021-04-23 JP JP2022564548A patent/JP2023523016A/ja active Pending
- 2021-04-23 EP EP21792975.1A patent/EP4110822A4/en active Pending
- 2021-04-23 BR BR112022019939A patent/BR112022019939A2/pt unknown
- 2021-04-23 AU AU2021261003A patent/AU2021261003A1/en active Pending
- 2021-04-23 US US17/995,800 patent/US20230140868A1/en active Pending
- 2021-04-23 MX MX2022013207A patent/MX2022013207A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2023523016A (ja) | 2023-06-01 |
AU2021261003A1 (en) | 2022-10-20 |
EP4110822A4 (en) | 2024-04-10 |
EP4110822A1 (en) | 2023-01-04 |
KR20230019424A (ko) | 2023-02-08 |
CN115485301A (zh) | 2022-12-16 |
IL296576A (en) | 2022-11-01 |
WO2021216956A1 (en) | 2021-10-28 |
BR112022019939A2 (pt) | 2022-12-13 |
US20230140868A1 (en) | 2023-05-11 |
CA3172092A1 (en) | 2021-10-28 |
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