MX2022012366A - Metodos para generar neuronas de dopamina del mesencefalo, neuronas del mesencefalo, y usos de las mismas. - Google Patents
Metodos para generar neuronas de dopamina del mesencefalo, neuronas del mesencefalo, y usos de las mismas.Info
- Publication number
- MX2022012366A MX2022012366A MX2022012366A MX2022012366A MX2022012366A MX 2022012366 A MX2022012366 A MX 2022012366A MX 2022012366 A MX2022012366 A MX 2022012366A MX 2022012366 A MX2022012366 A MX 2022012366A MX 2022012366 A MX2022012366 A MX 2022012366A
- Authority
- MX
- Mexico
- Prior art keywords
- midbrain
- neurons
- methods
- generating
- dopamine neurons
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Developmental Biology & Embryology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063004138P | 2020-04-02 | 2020-04-02 | |
| PCT/US2021/025596 WO2021203009A1 (en) | 2020-04-02 | 2021-04-02 | Methods of generating midbrain dopamine neurons, midbrain neurons and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022012366A true MX2022012366A (es) | 2022-12-15 |
Family
ID=77929755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022012366A MX2022012366A (es) | 2020-04-02 | 2021-04-02 | Metodos para generar neuronas de dopamina del mesencefalo, neuronas del mesencefalo, y usos de las mismas. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230143486A1 (https=) |
| EP (1) | EP4127137A4 (https=) |
| JP (2) | JP2023520466A (https=) |
| KR (1) | KR20220164012A (https=) |
| CN (1) | CN115768875A (https=) |
| AU (1) | AU2021248640A1 (https=) |
| BR (1) | BR112022019881A2 (https=) |
| CA (1) | CA3177525A1 (https=) |
| IL (1) | IL296919A (https=) |
| MX (1) | MX2022012366A (https=) |
| WO (1) | WO2021203009A1 (https=) |
| ZA (1) | ZA202211266B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023220639A2 (en) * | 2022-05-10 | 2023-11-16 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for improved memory in the aging |
| US12565639B2 (en) | 2023-06-13 | 2026-03-03 | Aspen Neuroscience, Inc. | Methods for differentiating dopaminergic neurons from stem cells |
| WO2025166063A1 (en) | 2024-01-31 | 2025-08-07 | Bluerock Therapeutics Lp | Igfbp2 in cell culture |
| WO2025252180A1 (zh) * | 2024-06-05 | 2025-12-11 | 中国科学院脑科学与智能技术卓越创新中心 | 中脑多巴胺能祖细胞群的体外制备方法 |
| WO2026006245A1 (en) * | 2024-06-25 | 2026-01-02 | Bluerock Therapeutics Lp | Three-dimensional culturing of pluripotent stem cells for improved differentiability |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3693455A1 (en) * | 2011-11-04 | 2020-08-12 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (da) neurons for engraftment |
| EP2614829A1 (en) * | 2012-01-11 | 2013-07-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons |
| WO2014161075A1 (en) * | 2013-04-05 | 2014-10-09 | University Health Network | Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue |
| EP3498824A1 (en) * | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
| WO2017160234A1 (en) * | 2016-03-14 | 2017-09-21 | Agency For Science, Technology And Research | Generation of midbrain-specific organoids from human pluripotent stem cells |
-
2021
- 2021-04-02 CN CN202180037655.4A patent/CN115768875A/zh active Pending
- 2021-04-02 BR BR112022019881A patent/BR112022019881A2/pt unknown
- 2021-04-02 EP EP21781937.4A patent/EP4127137A4/en active Pending
- 2021-04-02 AU AU2021248640A patent/AU2021248640A1/en active Pending
- 2021-04-02 KR KR1020227038245A patent/KR20220164012A/ko active Pending
- 2021-04-02 IL IL296919A patent/IL296919A/en unknown
- 2021-04-02 WO PCT/US2021/025596 patent/WO2021203009A1/en not_active Ceased
- 2021-04-02 JP JP2022559927A patent/JP2023520466A/ja active Pending
- 2021-04-02 CA CA3177525A patent/CA3177525A1/en active Pending
- 2021-04-02 MX MX2022012366A patent/MX2022012366A/es unknown
-
2022
- 2022-09-30 US US17/956,957 patent/US20230143486A1/en active Pending
- 2022-10-13 ZA ZA2022/11266A patent/ZA202211266B/en unknown
-
2025
- 2025-09-26 JP JP2025160105A patent/JP2025184905A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220164012A (ko) | 2022-12-12 |
| WO2021203009A1 (en) | 2021-10-07 |
| US20230143486A1 (en) | 2023-05-11 |
| CN115768875A (zh) | 2023-03-07 |
| JP2025184905A (ja) | 2025-12-18 |
| IL296919A (en) | 2022-12-01 |
| CA3177525A1 (en) | 2021-10-07 |
| EP4127137A4 (en) | 2024-05-22 |
| JP2023520466A (ja) | 2023-05-17 |
| AU2021248640A1 (en) | 2022-10-27 |
| EP4127137A1 (en) | 2023-02-08 |
| ZA202211266B (en) | 2023-05-31 |
| BR112022019881A2 (pt) | 2022-11-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2022012366A (es) | Metodos para generar neuronas de dopamina del mesencefalo, neuronas del mesencefalo, y usos de las mismas. | |
| MX2022007515A (es) | Inhibidores de sos1. | |
| MX389700B (es) | Derivados de pirazolopiridina como moduladores de cinasa 1 progenitora hematopoyetica (hpk1) y usos de los mismos para tratamiento de cancer. | |
| CL2019001709A1 (es) | Derivados pirazol como inhibidores de malt1. | |
| MX381069B (es) | Profármacos de carbidopa y l-dopa y métodos de uso. | |
| CO2022009438A2 (es) | Fluoroalquil-oxadiazoles y sus usos | |
| UY37349A (es) | Composiciones y métodos para inhibir masp-3 para el tratamiento de varias enfermedades y trastornos | |
| ECSP17013903A (es) | Protein kinase c inhibitors and methods of their use | |
| MX2022002532A (es) | Métodos para generar y aislar neuronas de dopamina del mesencéfalo. | |
| MX2020009602A (es) | Formulaciones de pulverizacion de epinefrina. | |
| CL2020000911A1 (es) | Inhibidores de la quinasa p38 que reducen la expresión de dux4 y de los genes corriente abajo para el tratamiento de fshd | |
| MX380866B (es) | Composiciones y métodos para modular la expresión del factor b del complemento. | |
| UY36091A (es) | Compuesto heterocíclico que contiene nitrógeno | |
| UY35472A (es) | Compuestos y sus usos en la modulacion de la hemoglobina | |
| MX2019000980A (es) | Compuestos y composiciones y usos de los mismos. | |
| CO2017004530A2 (es) | 2-amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de bace1 | |
| GT201700099A (es) | 2- amino-6-(difluorometil)-5,5-difluoro-6-fenil-3, 4, 5, 6-tetrahidropiridinas como inhibidores de bace1 | |
| ECSP19014247A (es) | Formas de dosificación para tratar y prevenir trastornos del sueño | |
| MX2017016413A (es) | Derivados de diaril y arilheteroaril urea como moduladores del receptor 5ht2a de serotonina útiles para la profilaxis y el tratamineto de un trastorno conductual del sueño rem. | |
| CL2021001656A1 (es) | Compuestos de imidazopiridina e imidazopiridina y sus usos. | |
| DOP2020000072A (es) | Amidas de imidazopiridina sustituidas y su uso | |
| MX2024007938A (es) | Indoles, indazoles y analogos relacionados para inhibir yap/taz-tead. | |
| MX2021000363A (es) | Uso de estimuladores de la guanilato ciclasa soluble (sgc) para el tratamiento de trastornos mitocondriales. | |
| CO2019012475A2 (es) | Composiciones y productos de fragancia novedosos con efectos mejoradores del estado de ánimo | |
| MX2020000523A (es) | Compuestos de isocromano y usos de los mismos. |