CN115768875A - 产生中脑多巴胺神经元的方法、中脑神经元及其用途 - Google Patents

产生中脑多巴胺神经元的方法、中脑神经元及其用途 Download PDF

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CN115768875A
CN115768875A CN202180037655.4A CN202180037655A CN115768875A CN 115768875 A CN115768875 A CN 115768875A CN 202180037655 A CN202180037655 A CN 202180037655A CN 115768875 A CN115768875 A CN 115768875A
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signaling
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L·施图德
T-W·金
S-Y·具
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Memorial Sloan Kettering Cancer Center
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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CN202180037655.4A 2020-04-02 2021-04-02 产生中脑多巴胺神经元的方法、中脑神经元及其用途 Pending CN115768875A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063004138P 2020-04-02 2020-04-02
US63/004,138 2020-04-02
PCT/US2021/025596 WO2021203009A1 (en) 2020-04-02 2021-04-02 Methods of generating midbrain dopamine neurons, midbrain neurons and uses thereof

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CN115768875A true CN115768875A (zh) 2023-03-07

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US (1) US20230143486A1 (https=)
EP (1) EP4127137A4 (https=)
JP (2) JP2023520466A (https=)
KR (1) KR20220164012A (https=)
CN (1) CN115768875A (https=)
AU (1) AU2021248640A1 (https=)
BR (1) BR112022019881A2 (https=)
CA (1) CA3177525A1 (https=)
IL (1) IL296919A (https=)
MX (1) MX2022012366A (https=)
WO (1) WO2021203009A1 (https=)
ZA (1) ZA202211266B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025252180A1 (zh) * 2024-06-05 2025-12-11 中国科学院脑科学与智能技术卓越创新中心 中脑多巴胺能祖细胞群的体外制备方法

Families Citing this family (4)

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WO2023220639A2 (en) * 2022-05-10 2023-11-16 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for improved memory in the aging
US12565639B2 (en) 2023-06-13 2026-03-03 Aspen Neuroscience, Inc. Methods for differentiating dopaminergic neurons from stem cells
WO2025166063A1 (en) 2024-01-31 2025-08-07 Bluerock Therapeutics Lp Igfbp2 in cell culture
WO2026006245A1 (en) * 2024-06-25 2026-01-02 Bluerock Therapeutics Lp Three-dimensional culturing of pluripotent stem cells for improved differentiability

Citations (5)

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Publication number Priority date Publication date Assignee Title
EP2614829A1 (en) * 2012-01-11 2013-07-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons
CN104379731A (zh) * 2011-11-04 2015-02-25 纪念斯隆-凯特琳癌症中心 用于植入的中脑多巴胺(da)神经元
CN105209607A (zh) * 2013-04-05 2015-12-30 大学健康网络 产生软骨细胞谱系细胞和/或类软骨组织的方法和组合物
US20160115448A1 (en) * 2013-04-26 2016-04-28 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
CN109996870A (zh) * 2016-03-14 2019-07-09 新加坡科技研究局 从人多能干细胞产生中脑特异性类器官

Patent Citations (5)

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CN104379731A (zh) * 2011-11-04 2015-02-25 纪念斯隆-凯特琳癌症中心 用于植入的中脑多巴胺(da)神经元
EP2614829A1 (en) * 2012-01-11 2013-07-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons
CN105209607A (zh) * 2013-04-05 2015-12-30 大学健康网络 产生软骨细胞谱系细胞和/或类软骨组织的方法和组合物
US20160115448A1 (en) * 2013-04-26 2016-04-28 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
CN109996870A (zh) * 2016-03-14 2019-07-09 新加坡科技研究局 从人多能干细胞产生中脑特异性类器官

Non-Patent Citations (2)

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Title
BIN SONG等: "Human autologous iPSC–derived dopaminergic progenitors restore motor function in Parkinson’s disease models", J CLIN INVEST., vol. 130, no. 2, 3 February 2020 (2020-02-03), pages 904, XP093099657, DOI: 10.1172/JCI130767 *
TAE HWAN KWAK等: "Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson\'s disease modeling", STEM CELLS, vol. 38, no. 6, 28 February 2020 (2020-02-28), pages 729 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025252180A1 (zh) * 2024-06-05 2025-12-11 中国科学院脑科学与智能技术卓越创新中心 中脑多巴胺能祖细胞群的体外制备方法

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KR20220164012A (ko) 2022-12-12
WO2021203009A1 (en) 2021-10-07
US20230143486A1 (en) 2023-05-11
JP2025184905A (ja) 2025-12-18
IL296919A (en) 2022-12-01
CA3177525A1 (en) 2021-10-07
EP4127137A4 (en) 2024-05-22
JP2023520466A (ja) 2023-05-17
AU2021248640A1 (en) 2022-10-27
MX2022012366A (es) 2022-12-15
EP4127137A1 (en) 2023-02-08
ZA202211266B (en) 2023-05-31
BR112022019881A2 (pt) 2022-11-22

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