MX2022012139A - Un metodo para medir el ph de una muestra. - Google Patents

Un metodo para medir el ph de una muestra.

Info

Publication number
MX2022012139A
MX2022012139A MX2022012139A MX2022012139A MX2022012139A MX 2022012139 A MX2022012139 A MX 2022012139A MX 2022012139 A MX2022012139 A MX 2022012139A MX 2022012139 A MX2022012139 A MX 2022012139A MX 2022012139 A MX2022012139 A MX 2022012139A
Authority
MX
Mexico
Prior art keywords
solution
sample
function
present
methods
Prior art date
Application number
MX2022012139A
Other languages
English (en)
Inventor
Kushagr Punyani
Per Andreas Nyberg
Sindre Søpstad
Martin Peacock
Linhongjia Xiong
Jae Yen Shin
Original Assignee
Diagonal Bio Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagonal Bio Ab filed Critical Diagonal Bio Ab
Publication of MX2022012139A publication Critical patent/MX2022012139A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/302—Electrodes, e.g. test electrodes; Half-cells pH sensitive, e.g. quinhydron, antimony or hydrogen electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/80—Indicating pH value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus
    • G01N27/4165—Systems checking the operation of, or calibrating, the measuring apparatus for pH meters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4166—Systems measuring a particular property of an electrolyte
    • G01N27/4167—Systems measuring a particular property of an electrolyte pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/115—Characterised by chemical treatment oxidising agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/119—Reactions demanding special reaction conditions pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/137—Concentration of a component of medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/607—Detection means characterised by use of a special device being a sensor, e.g. electrode

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Electrochemistry (AREA)
  • Plasma & Fusion (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La presente invención proporciona un método más sensible y preciso para monitorear el pH de una solución, en donde el pH de la solución se cuantifica como una función de la respuesta electroquímica de la solución en una celda electroquímica de dos o tres electrodos, en donde la solución comprende un compuesto capaz de someterse a un cambio en su estado de oxidación y/o conformación estructural como una función del pH de la solución. La presente invención también proporciona métodos altamente acelerados y procesos que permiten el análisis de las secuencias de polinucleótidos específicas en una muestra, por ejemplo, una muestra biológica. Los métodos de las invenciones, por ejemplo, son útiles para la rápida clasificación de una gran cantidad de muestras en un entorno en el punto de cuidado.
MX2022012139A 2020-04-03 2021-04-06 Un metodo para medir el ph de una muestra. MX2022012139A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20168019 2020-04-03
EP20197572 2020-09-22
PCT/EP2021/058946 WO2021198533A1 (en) 2020-04-03 2021-04-06 A method of measuring the ph of a sample

Publications (1)

Publication Number Publication Date
MX2022012139A true MX2022012139A (es) 2022-10-18

Family

ID=75339765

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022012139A MX2022012139A (es) 2020-04-03 2021-04-06 Un metodo para medir el ph de una muestra.

Country Status (14)

Country Link
US (1) US20230074766A1 (es)
EP (1) EP3987059B1 (es)
JP (1) JP2023520419A (es)
KR (1) KR20220161286A (es)
CN (1) CN115362265A (es)
AU (1) AU2021249488A1 (es)
BR (1) BR112022017446A2 (es)
CA (1) CA3168685C (es)
DK (1) DK3987059T3 (es)
ES (1) ES2928304T3 (es)
IL (1) IL296011B2 (es)
MX (1) MX2022012139A (es)
WO (1) WO2021198533A1 (es)
ZA (1) ZA202208804B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2932875A1 (es) * 2021-07-20 2023-01-27 Univ Oviedo Método para la detección de un material genético en una muestra y dispositivo para llevarlo a cabo
WO2024064704A1 (en) * 2022-09-19 2024-03-28 Rt Microdx Inc. Pathogen testing device and method
CN117147662B (zh) * 2023-08-02 2024-03-08 中南林业科技大学 一种大肠杆菌活性的电化学检测方法
CN116908244B (zh) * 2023-09-13 2023-12-22 四川省林业和草原调查规划院 一种林业生态保护用采样装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820399A (en) * 1984-08-31 1989-04-11 Shimadzu Corporation Enzyme electrodes
JP2004141158A (ja) * 2002-10-01 2004-05-20 Matsushita Electric Ind Co Ltd プライマーの伸長反応検出方法、塩基種判別方法、塩基種判別装置、ピロリン酸の検出装置、核酸の検出方法および試料溶液導入チップ
US20160077015A1 (en) * 2011-09-25 2016-03-17 Theranos, Inc. Systems and methods for multi-analysis
GB2501769A (en) * 2012-05-04 2013-11-06 Schlumberger Holdings Electrochemical sensor for pH measurement
US9034606B2 (en) 2012-08-23 2015-05-19 New England Biolabs, Inc. Detection of an amplification reaction product using pH-sensitive dyes
CN104232615A (zh) * 2013-06-09 2014-12-24 中国科学院上海应用物理研究所 基于电化学-dna反应控制芯片的酸碱法扩增dna片段技术
US10011549B2 (en) * 2015-07-06 2018-07-03 Robert Bosch Gmbh Electrochemically active agents for pH modulation in biological buffers
WO2017155858A1 (en) * 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
WO2017209920A1 (en) 2016-06-03 2017-12-07 New England Biolabs, Inc. Detection of an amplification reaction product using ph-sensitive dyes

Also Published As

Publication number Publication date
EP3987059A1 (en) 2022-04-27
ES2928304T3 (es) 2022-11-16
ZA202208804B (en) 2023-04-26
DK3987059T3 (da) 2022-10-03
EP3987059B1 (en) 2022-07-06
CA3168685A1 (en) 2021-10-07
BR112022017446A2 (pt) 2023-01-17
JP2023520419A (ja) 2023-05-17
WO2021198533A1 (en) 2021-10-07
AU2021249488A1 (en) 2022-09-08
CN115362265A (zh) 2022-11-18
US20230074766A1 (en) 2023-03-09
KR20220161286A (ko) 2022-12-06
CA3168685C (en) 2023-05-16
IL296011A (en) 2022-10-01
IL296011B2 (en) 2023-07-01
IL296011B1 (en) 2023-03-01

Similar Documents

Publication Publication Date Title
MX2022012139A (es) Un metodo para medir el ph de una muestra.
Lubert et al. History of electroanalytical methods
DE69128425D1 (de) Methoden und material für die trennung, konzentrierung und analyse von zellen
MXPA06001914A (es) Metodo y aparato para ensayo de propiedades electroquimicas.
DE60317422D1 (de) Mediator-stabilisierende Verbindung und Methoden zur Verwendung zur Detektion elektrochemischer Analyte
KR20160143804A (ko) 세포의 분화 상태의 평가 방법
Apostolou et al. Extraction-less, rapid assay for the direct detection of 2, 4, 6-trichloroanisole (TCA) in cork samples
CN104212803A (zh) 用于汞离子定量快速检测的核酸适配体序列及其检测方法
Gross et al. Nitrite/nitrate detection in serum based on dual-plate generator–collector currents in a microtrench
Shi et al. Binary DNA hairpin-based colorimetric biochip for simultaneous detection of Pb 2+ and Hg 2+ in real-world samples
WO2011079937A3 (en) Method for measuring analyte concentration in a liquid sample
Zhou et al. Wireless USB-like electrochemical platform for individual electrochemical sensing in microdroplets
Zhang et al. Recording the Reaction Process of Loop‐Mediated Isothermal Amplification (LAMP) by Monitoring the Voltammetric Response of 2′‐Deoxyguanosine 5′‐Triphosphate
CN107525936B (zh) 一种提升胶乳免疫比浊法中肌钙蛋白抗体稳定性的组合物
JP2016533746A (ja) 多孔質基材における核酸増幅の検出
Ma et al. A highly sensitive and adjustable colorimetric assay of hydrogen sulfide by signal amplification based on G-quadruplex-Cu 2+ peroxidase mimetics
DE50113601D1 (de) Verfahren und vorrichtung zum analysieren von chemischen oder biologischen proben
Sužnjević et al. DC polarographic examination of Hg2+ reduction applicability to antioxidant activity determination
EP3865213A3 (de) Verfahren zum nachweis von lebenden mikroorganismen und ein fluidisches kanalsystem
Dou et al. Electrochimical determination of uric acid, xanthine and hypoxanthine by poly (xylitol) modified glassy carbon electrode
CN104359957B (zh) 一种电化学传感器及其制备与应用
RU2460767C1 (ru) Способ оценки метаболической активности клеток и устройство для его осуществления
MX2020014093A (es) Metodo electroquimico enzimatico para la cuantificacion de analitos en muestras de fluidos biologicos.
RU2390009C2 (ru) Способ оценки депуринизации нуклеиновых кислот и устройство для его осуществления
Kammarchedu et al. Advancing Electrochemical Screening of Neurotransmitters Using a Customizable Machine Learning-Based Multimodal System