MX2022011364A - Heteromultímeros de actriia y actriib de un solo brazo y metodos para el tratamiento de enfermedades o condiciones renales. - Google Patents
Heteromultímeros de actriia y actriib de un solo brazo y metodos para el tratamiento de enfermedades o condiciones renales.Info
- Publication number
- MX2022011364A MX2022011364A MX2022011364A MX2022011364A MX2022011364A MX 2022011364 A MX2022011364 A MX 2022011364A MX 2022011364 A MX2022011364 A MX 2022011364A MX 2022011364 A MX2022011364 A MX 2022011364A MX 2022011364 A MX2022011364 A MX 2022011364A
- Authority
- MX
- Mexico
- Prior art keywords
- arm
- conditions
- methods
- heteromultimers
- actriia
- Prior art date
Links
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 title abstract 3
- 208000017169 kidney disease Diseases 0.000 title abstract 2
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 abstract 2
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 abstract 2
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 abstract 1
- 208000024985 Alport syndrome Diseases 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 208000003215 hereditary nephritis Diseases 0.000 abstract 1
- 208000030761 polycystic kidney disease Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2006—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
En algunos aspectos, la descripción se refiere a heteromultímeros de ActRIIA de un solo brazo y heteromultímeros de ActRIIB de un solo brazo y a métodos para usar dichos heteromultímeros para tratar, prevenir o reducir la tasa de progresión y/o la gravedad de las enfermedades o afecciones renales, particularmente para tratar, prevenir o reducir la tasa de progresión y/o la gravedad de una o más complicaciones asociadas con el riñón. La descripción también proporciona métodos para usar un heteromultímero de ActRIIA de un solo brazo o heteromultímero de ActRIIB de un solo brazo para tratar, prevenir o reducir la velocidad de progresión y/o gravedad de una variedad de afecciones que incluyen, de modo no taxativo, síndrome de Alport, glomeruloesclerosis focal segmentaria (FSGS), enfermedad renal poliquística y/o enfermedad renal crónica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062989037P | 2020-03-13 | 2020-03-13 | |
PCT/US2021/021991 WO2021183819A1 (en) | 2020-03-13 | 2021-03-11 | Single-arm actriia and actriib heteromultimers and methods for treating renal diseases or conditions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022011364A true MX2022011364A (es) | 2022-11-30 |
Family
ID=77672098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022011364A MX2022011364A (es) | 2020-03-13 | 2021-03-11 | Heteromultímeros de actriia y actriib de un solo brazo y metodos para el tratamiento de enfermedades o condiciones renales. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230134083A1 (es) |
EP (1) | EP4117707A1 (es) |
JP (1) | JP2023528117A (es) |
KR (1) | KR20230002391A (es) |
CN (1) | CN115515618A (es) |
AU (1) | AU2021236249A1 (es) |
BR (1) | BR112022018319A2 (es) |
CA (1) | CA3171638A1 (es) |
MX (1) | MX2022011364A (es) |
WO (1) | WO2021183819A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117137924A (zh) * | 2023-09-28 | 2023-12-01 | 宜兴食品与生物技术研究院有限公司 | N-乙酰-d-甘露糖胺在制备促进骨生长的食品及药物中的应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA53883A (fr) * | 2015-04-06 | 2021-08-18 | Acceleron Pharma Inc | Protéines de fusion de récepteur type i et type ii à bras unique et leurs utilisations |
BR112017021510A2 (pt) * | 2015-04-06 | 2018-07-03 | Acceleron Pharma Inc | heteromultímeros do receptor tipo i e tipo ii da superfamília tgf-beta e sua utilização |
CN116650622A (zh) * | 2016-10-05 | 2023-08-29 | 艾科赛扬制药股份有限公司 | 用于治疗肾脏疾病的组合物和方法 |
EP3522913A4 (en) * | 2016-10-05 | 2020-10-28 | Acceleron Pharma Inc. | ALK4: ACTRIIB HETEROMULTIMERS AND USES THEREOF |
-
2021
- 2021-03-11 US US17/911,347 patent/US20230134083A1/en active Pending
- 2021-03-11 AU AU2021236249A patent/AU2021236249A1/en active Pending
- 2021-03-11 WO PCT/US2021/021991 patent/WO2021183819A1/en active Application Filing
- 2021-03-11 KR KR1020227035212A patent/KR20230002391A/ko unknown
- 2021-03-11 MX MX2022011364A patent/MX2022011364A/es unknown
- 2021-03-11 CN CN202180033625.6A patent/CN115515618A/zh active Pending
- 2021-03-11 CA CA3171638A patent/CA3171638A1/en active Pending
- 2021-03-11 EP EP21767054.6A patent/EP4117707A1/en active Pending
- 2021-03-11 BR BR112022018319A patent/BR112022018319A2/pt not_active Application Discontinuation
- 2021-03-11 JP JP2022554931A patent/JP2023528117A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3171638A1 (en) | 2021-09-16 |
KR20230002391A (ko) | 2023-01-05 |
EP4117707A1 (en) | 2023-01-18 |
CN115515618A (zh) | 2022-12-23 |
BR112022018319A2 (pt) | 2022-11-22 |
AU2021236249A1 (en) | 2022-10-06 |
WO2021183819A1 (en) | 2021-09-16 |
JP2023528117A (ja) | 2023-07-04 |
US20230134083A1 (en) | 2023-05-04 |
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