MX2022010620A - Profarmacos de esteroides neuroactivos. - Google Patents
Profarmacos de esteroides neuroactivos.Info
- Publication number
- MX2022010620A MX2022010620A MX2022010620A MX2022010620A MX2022010620A MX 2022010620 A MX2022010620 A MX 2022010620A MX 2022010620 A MX2022010620 A MX 2022010620A MX 2022010620 A MX2022010620 A MX 2022010620A MX 2022010620 A MX2022010620 A MX 2022010620A
- Authority
- MX
- Mexico
- Prior art keywords
- prodrugs
- salts
- sub
- compounds disclosed
- neuroactive steroids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/009—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by only one oxygen atom doubly bound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062982717P | 2020-02-27 | 2020-02-27 | |
| PCT/US2021/020308 WO2021174205A1 (en) | 2020-02-27 | 2021-03-01 | Prodrugs of neuroactive steroids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022010620A true MX2022010620A (es) | 2022-11-30 |
Family
ID=77491637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022010620A MX2022010620A (es) | 2020-02-27 | 2021-03-01 | Profarmacos de esteroides neuroactivos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230416298A1 (he) |
| EP (1) | EP4110345A4 (he) |
| JP (1) | JP2023514873A (he) |
| KR (1) | KR20230037006A (he) |
| CN (1) | CN115461055B (he) |
| AU (1) | AU2021226902A1 (he) |
| BR (1) | BR112022016947A2 (he) |
| CA (1) | CA3172901A1 (he) |
| IL (1) | IL295902A (he) |
| MX (1) | MX2022010620A (he) |
| TW (1) | TW202146027A (he) |
| WO (1) | WO2021174205A1 (he) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202112111WA (en) | 2019-05-10 | 2021-11-29 | Brii Biosciences Inc | Pharmaceutical composition containing brexanolone, ganaxolone, or zuranolone, and use thereof |
| WO2021142477A1 (en) * | 2020-01-12 | 2021-07-15 | Brii Biosciences, Inc. | Neuroactive steroids and pharmaceutical composition containing the same |
| CN114344309B (zh) * | 2021-12-30 | 2024-02-06 | 南京迈诺威医药科技有限公司 | 一种别孕烷醇酮衍生物自乳化制剂及其制备方法 |
| IL315509A (he) * | 2022-03-18 | 2024-11-01 | Marinus Pharmaceuticals Inc | מטרימי תרופות של גנקסולון |
| CN119816292A (zh) * | 2022-08-08 | 2025-04-11 | 先进核糖核酸疫苗(Arv)技术股份有限公司 | 基于甾醇的可电离脂质以及包含其的脂质纳米颗粒 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK24089D0 (da) * | 1989-01-20 | 1989-01-20 | Hans Bundgaard | Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups |
| KR100338287B1 (ko) * | 1994-02-14 | 2002-11-30 | 푸르듀 파머 리미티드 | 감마-아미노부티르산a수용체의알로오스테리조절용안드로스탄및프레그난 |
| FI972202L (fi) * | 1994-11-23 | 1997-07-17 | Cocensys Inc | Androstaanit ja pregnaanit GABA-reseptoreiden allosteeriseen muunteluun |
| WO2010088409A2 (en) * | 2009-01-30 | 2010-08-05 | Emory University | Methods of neuroprotection using neuroprotective steroids and a vitamin d |
| WO2011120044A1 (en) * | 2010-03-26 | 2011-09-29 | Duke University | Conjugated neuroactive steroid compositions and methods of use |
| CZ303443B6 (cs) * | 2011-02-15 | 2012-09-12 | Ústav organické chemie a biochemie Akademie ved CR, v.v.i. | Deriváty pregnanolonu substituované v poloze 3alfa kationickou skupinou, zpusob jejich výroby, jejich použití a prostredek je obsahující |
| FR2973031B1 (fr) * | 2011-03-23 | 2013-11-29 | Univ Strasbourg | Derives de l'allopregnanolone et de l'epiallopregnanolone et leurs utilisations pour traiter un etat neuropathologique |
| CN119192266A (zh) * | 2011-10-14 | 2024-12-27 | 萨奇治疗股份有限公司 | 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途 |
| US20170022245A1 (en) * | 2013-11-26 | 2017-01-26 | Biopharma Works | Ganaxolone derivatives for treatment of central nervous systems disorders |
| US10137137B2 (en) * | 2013-12-23 | 2018-11-27 | Socpra Sciences Et Genie S.E.C. | ATP synthase inhibitors and steroid alkaloids and uses thereof as antimicrobial agents and as potentiators for aminoglycosides against pathogenic bacteria |
| EP3612186A1 (en) * | 2017-04-18 | 2020-02-26 | Marinus Pharmaceuticals, Inc. | Sustained release injectable neurosteroid formulations |
| US20190337975A1 (en) * | 2018-05-04 | 2019-11-07 | Acerus Pharmaceuticals Corporation | Neurosteroid derivatives and uses thereof |
| CN108517001A (zh) * | 2018-05-17 | 2018-09-11 | 江苏恩华络康药物研发有限公司 | 水溶性别孕烯醇酮衍生物及其用途 |
| US20210300962A1 (en) * | 2018-08-02 | 2021-09-30 | Puretech Lyt, Inc. | Lipid prodrugs of pregnane neurosteroids and uses thereof |
| SG11202112111WA (en) * | 2019-05-10 | 2021-11-29 | Brii Biosciences Inc | Pharmaceutical composition containing brexanolone, ganaxolone, or zuranolone, and use thereof |
| CR20240234A (es) * | 2019-05-31 | 2024-07-09 | Sage Therapeutics Inc | ESTEROIDES NEUROACTIVOS Y COMPOSICIONES DE ESTOS (Divisional 2021-629) |
| CN115348864A (zh) * | 2020-02-05 | 2022-11-15 | 纯技术Lyt股份有限公司 | 神经甾体的脂质前药 |
| KR102885834B1 (ko) * | 2020-04-10 | 2025-11-12 | 주식회사 엘지에너지솔루션 | 전지 모듈 및 이를 포함하는 전지 팩 |
-
2021
- 2021-03-01 MX MX2022010620A patent/MX2022010620A/es unknown
- 2021-03-01 IL IL295902A patent/IL295902A/he unknown
- 2021-03-01 EP EP21761246.4A patent/EP4110345A4/en not_active Withdrawn
- 2021-03-01 BR BR112022016947A patent/BR112022016947A2/pt unknown
- 2021-03-01 CN CN202180031289.1A patent/CN115461055B/zh active Active
- 2021-03-01 AU AU2021226902A patent/AU2021226902A1/en active Pending
- 2021-03-01 KR KR1020227033404A patent/KR20230037006A/ko not_active Withdrawn
- 2021-03-01 CA CA3172901A patent/CA3172901A1/en active Pending
- 2021-03-01 US US17/801,894 patent/US20230416298A1/en active Pending
- 2021-03-01 JP JP2022551639A patent/JP2023514873A/ja active Pending
- 2021-03-01 WO PCT/US2021/020308 patent/WO2021174205A1/en not_active Ceased
- 2021-03-02 TW TW110107352A patent/TW202146027A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL295902A (he) | 2022-10-01 |
| CN115461055B (zh) | 2025-01-28 |
| US20230416298A1 (en) | 2023-12-28 |
| BR112022016947A2 (pt) | 2022-10-25 |
| JP2023514873A (ja) | 2023-04-11 |
| WO2021174205A1 (en) | 2021-09-02 |
| EP4110345A1 (en) | 2023-01-04 |
| CA3172901A1 (en) | 2021-09-02 |
| CN115461055A (zh) | 2022-12-09 |
| KR20230037006A (ko) | 2023-03-15 |
| EP4110345A4 (en) | 2024-05-15 |
| AU2021226902A1 (en) | 2022-09-22 |
| TW202146027A (zh) | 2021-12-16 |
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