MX2022009961A - Método para producir biomaterial descelularizado, material descelularizado y usos de este. - Google Patents
Método para producir biomaterial descelularizado, material descelularizado y usos de este.Info
- Publication number
- MX2022009961A MX2022009961A MX2022009961A MX2022009961A MX2022009961A MX 2022009961 A MX2022009961 A MX 2022009961A MX 2022009961 A MX2022009961 A MX 2022009961A MX 2022009961 A MX2022009961 A MX 2022009961A MX 2022009961 A MX2022009961 A MX 2022009961A
- Authority
- MX
- Mexico
- Prior art keywords
- biomaterial
- decellularized biomaterial
- biological
- producing
- decellularized
- Prior art date
Links
- 239000012620 biological material Substances 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 210000001519 tissue Anatomy 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 230000037361 pathway Effects 0.000 abstract 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000003786 sclera Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
Abstract
Esta solicitud de patente hace referencia al campo de la ingeniería de tejidos. En particular, hace referencia a un método para producir el biomaterial descelularizado a partir de tejidos biológicos, así como al biomaterial descelularizado producido por dicho método que comprende una matriz extracelular biológica. Especialmente, dicho tejido biológico deriva del tejido conjuntivo del ojo humano o un animal. Más específicamente, hace referencia a un método para producir biomaterial descelularizado de la esclerótica animal para producir una estructura biológica básica, prótesis y/o como vehículos de sustancias activas (o combinado con sustancias activas), así como el biomaterial en sí mismo y usos de este como estructuras básicas, prótesis o vehículos de sustancias para liberación sistémica o localizada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062976956P | 2020-02-14 | 2020-02-14 | |
PCT/BR2021/050069 WO2021159198A1 (pt) | 2020-02-14 | 2021-02-12 | Método de produção de biomaterial descelularizado, biomaterial descelularizado e uso do mesmo |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022009961A true MX2022009961A (es) | 2022-11-14 |
Family
ID=77291950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022009961A MX2022009961A (es) | 2020-02-14 | 2021-02-12 | Método para producir biomaterial descelularizado, material descelularizado y usos de este. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP4104863A4 (es) |
JP (1) | JP2023517179A (es) |
KR (1) | KR20220161290A (es) |
AU (1) | AU2021220753A1 (es) |
BR (1) | BR112022016166A2 (es) |
CA (1) | CA3171328A1 (es) |
IL (1) | IL295582A (es) |
MX (1) | MX2022009961A (es) |
WO (1) | WO2021159198A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114796615B (zh) * | 2022-04-20 | 2023-08-25 | 诺一迈尔(苏州)医学科技有限公司 | 一种软骨脱细胞基质及其制备方法 |
CN115837096A (zh) * | 2022-08-19 | 2023-03-24 | 山东第一医科大学附属眼科研究所(山东省眼科研究所、山东第一医科大学附属青岛眼科医院) | 一种基于透明化巩膜的角膜修复材料及其制备方法和应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1278559B1 (en) * | 2000-04-28 | 2008-03-26 | Baylor College Of Medicine | Decellularised vascular prostheses |
US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
US20110212524A1 (en) * | 2006-12-04 | 2011-09-01 | Body Organ Biomedical Corporation | Biomaterial and preparation method thereof |
WO2009120549A2 (en) * | 2008-03-24 | 2009-10-01 | Euclid Systems Corporation | Methods to increase permeability of corneal epithelium and destabilize stromal collagen fibril network |
CA2791158C (en) * | 2010-02-26 | 2020-07-21 | Decell Technologies Inc. | Methods for tissue decellularization |
CN101947144B (zh) | 2010-09-29 | 2012-07-04 | 厦门大学 | 一种板层组织工程角膜支架及其制作方法与应用 |
BR102014003817B1 (pt) * | 2014-02-19 | 2023-09-26 | Fundação Universidade Federal De São Carlos | Processo de recobrimento descontínuo utilizando um biomaterial bioabsorvível e bioativo aplicado sobre substratos sólidos, recobrimento descontínuo e seu uso |
US10675381B2 (en) | 2015-09-08 | 2020-06-09 | Clemson University Research Foundation | Decellularized biomaterial and method for formation |
CN105833353B (zh) | 2016-05-09 | 2018-04-20 | 拜欧迪赛尔(北京)生物科技有限公司 | 一种生物工程脱细胞真皮基质的制备及用途 |
CN105944142B (zh) | 2016-05-09 | 2018-07-13 | 拜欧迪赛尔(北京)生物科技有限公司 | 一种脱细胞肌腱或韧带支架的制备方法 |
KR20180003879A (ko) | 2016-07-01 | 2018-01-10 | 순천향대학교 산학협력단 | 탈세포화용 생물반응기 시스템과, 이를 이용한 기관의 탈세포화 방법 |
RU2653489C2 (ru) | 2016-09-02 | 2018-05-08 | Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный медицинский биофизический центр имени А.И. Бурназяна Федерального медико-биологического агентства" (ФГБУ "ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России") | Способ получения децеллюляризированных матриксов паренхиматозных органов лабораторных животных |
CN106362212A (zh) * | 2016-10-21 | 2017-02-01 | 华中科技大学同济医学院附属协和医院 | 一种用于去除组织细胞的亲脂性去细胞溶液、试剂盒和方法 |
CN106614519B (zh) * | 2016-11-24 | 2019-11-19 | 山东省眼科研究所 | 一种脱细胞角膜缘保护液及脱细胞角膜缘的制备方法 |
CN106729999B (zh) * | 2016-11-24 | 2019-11-19 | 山东省眼科研究所 | 一种构建组织工程角膜缘的方法 |
CN106730005A (zh) | 2016-12-22 | 2017-05-31 | 深圳艾尼尔角膜工程有限公司 | 一种角膜基质及其制备方法 |
CN107007886B (zh) | 2017-03-03 | 2018-02-06 | 北京博辉瑞进生物科技有限公司 | 一种生物组织基质材料、制备方法及其用途 |
KR20180133172A (ko) | 2017-06-05 | 2018-12-13 | 주식회사 티앤알바이오팹 | 골 이식재 고정용 주사형 접착제 조성물의 제조방법 및 이를 통해 제조된 골 이식재 고정용 주사형 접착제 조성물 |
CN108888804B (zh) * | 2018-07-27 | 2021-05-14 | 山东省眼科研究所 | 一种软组织修复材料及其制备方法 |
-
2021
- 2021-02-12 CA CA3171328A patent/CA3171328A1/en active Pending
- 2021-02-12 BR BR112022016166A patent/BR112022016166A2/pt unknown
- 2021-02-12 MX MX2022009961A patent/MX2022009961A/es unknown
- 2021-02-12 KR KR1020227031839A patent/KR20220161290A/ko unknown
- 2021-02-12 IL IL295582A patent/IL295582A/en unknown
- 2021-02-12 EP EP21754359.4A patent/EP4104863A4/en active Pending
- 2021-02-12 JP JP2022549335A patent/JP2023517179A/ja active Pending
- 2021-02-12 WO PCT/BR2021/050069 patent/WO2021159198A1/pt unknown
- 2021-02-12 AU AU2021220753A patent/AU2021220753A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IL295582A (en) | 2022-10-01 |
BR112022016166A2 (pt) | 2022-10-04 |
EP4104863A1 (en) | 2022-12-21 |
WO2021159198A1 (pt) | 2021-08-19 |
KR20220161290A (ko) | 2022-12-06 |
CA3171328A1 (en) | 2021-08-19 |
EP4104863A4 (en) | 2024-02-21 |
JP2023517179A (ja) | 2023-04-24 |
AU2021220753A1 (en) | 2022-10-06 |
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