MX2022009448A - Inhibidor de micro ácido ribonucleico 485 (miarn-485) para regulación génica por incremento. - Google Patents

Inhibidor de micro ácido ribonucleico 485 (miarn-485) para regulación génica por incremento.

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Publication number
MX2022009448A
MX2022009448A MX2022009448A MX2022009448A MX2022009448A MX 2022009448 A MX2022009448 A MX 2022009448A MX 2022009448 A MX2022009448 A MX 2022009448A MX 2022009448 A MX2022009448 A MX 2022009448A MX 2022009448 A MX2022009448 A MX 2022009448A
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Mexico
Prior art keywords
protein
gene expression
level
nxph1
gria4
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MX2022009448A
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English (en)
Inventor
Jin-Hyeob Ryu
Yu Na Lim
Hyun Su Min
Han Seok Koh
Dae Hoon Kim
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Biorchestra Co Ltd
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Publication date
Application filed by Biorchestra Co Ltd filed Critical Biorchestra Co Ltd
Publication of MX2022009448A publication Critical patent/MX2022009448A/es

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Abstract

La presente descripción incluye el uso de un inhibidor de miARN para el tratamiento de una enfermedad o afección asociadas con un nivel disminuido de proteína SIRT1, PGC-1a, CD36, LRRK2, NRG1, STMN2, VLDLR, NRXN1, GRIA4, NXPH1, PSD-95 y/o sinaptofisina, o de expresión génica de SIRT1, PGC-1a, CD36, LRRK2, NRG1, STMN2, VLDLR, NRXN1, GRIA4, NXPH1, PSD-95 y/o sinaptofisina. En algunos aspectos, el inhibidor de miARN puede usarse para tratar una enfermedad o afección asociadas con un nivel aumentado de proteína o de expresión génica de caspasa-3. El inhibidor de miARN útil para la presente descripción puede inhibir la expresión y/o actividad de miR 485, que a su vez puede aumentar el nivel de proteína o expresión génica de SIRT1, PGC-1a, CD36, LRRK2, NRG1, STMN2, VLDLR, NRXN1, GRIA4, NXPH1, PSD-95 y/o sinaptofisina; y/o disminuir el nivel de proteína o expresión génica de caspasa 3.
MX2022009448A 2020-02-07 2021-02-05 Inhibidor de micro ácido ribonucleico 485 (miarn-485) para regulación génica por incremento. MX2022009448A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062971767P 2020-02-07 2020-02-07
US202062989486P 2020-03-13 2020-03-13
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JPWO2019240223A1 (ja) * 2018-06-13 2021-07-01 公益財団法人川崎市産業振興財団 数平均分子量が３ｋＤａ〜１０ｋＤａであるＰＥＧブロックとカチオン性ポリマーとのブロックコポリマーと、アンチセンスオリゴヌクレオチドとを含む、ポリイオンコンプレックスミセル
KR20220024160A (ko) * 2019-06-17 2022-03-03 주식회사 바이오오케스트라 마이크로rna를 이용하여 알츠하이머 질환 동물 모델을 준비하기 위한 조성물 및 방법

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