MX2022004698A - Agente trombolitico para trombos intravasculares. - Google Patents

Agente trombolitico para trombos intravasculares.

Info

Publication number
MX2022004698A
MX2022004698A MX2022004698A MX2022004698A MX2022004698A MX 2022004698 A MX2022004698 A MX 2022004698A MX 2022004698 A MX2022004698 A MX 2022004698A MX 2022004698 A MX2022004698 A MX 2022004698A MX 2022004698 A MX2022004698 A MX 2022004698A
Authority
MX
Mexico
Prior art keywords
intravascular thrombus
seq
polypeptide
intravascular
thrombus
Prior art date
Application number
MX2022004698A
Other languages
English (en)
Inventor
Seong Tshool Hong
Hyeon Jin Kim
Mdmehedi Hassan
Original Assignee
Jinis Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jinis Co Ltd filed Critical Jinis Co Ltd
Publication of MX2022004698A publication Critical patent/MX2022004698A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21089—Signal peptidase I (3.4.21.89)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21107—Peptidase Do (3.4.21.107)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a un agente trombolítico para el "trombo intravascular" y, muy particularmente, a un agente trombolítico que tiene un dominio de reconocimiento de trombo y un dominio trombolítico. También se refiere a un polipéptido para la trombólisis de un trombo intravascular, un gen para ese polipéptido y una composición farmacéutica que lo contiene. El polipéptido que reconoce el 'trombo intravascular' y disuelve el trombo de la presente invención se caracteriza porque consiste en un dominio trombolítico que comprende la secuencia de aminoácidos expuesta en SEQ ID NO: 1 o SEQ ID NO: 2 y un dominio de reconocimiento de trombo que comprende la secuencia de aminoácidos expuesta en SEQ ID NO: 3 o SEQ ID NO: 4. De conformidad con la presente invención, el polipéptido para disolver trombos mediante el reconocimiento de "trombos intravasculares" disuelve trombos en la sangre de un mamífero sin efectos secundarios graves de sangrado y tiene un efecto preventivo y terapéutico sobre la trombosis, previniendo así la trombosis y enfermedades relacionadas. O puede ser ampliamente usado como agente terapéutico.
MX2022004698A 2019-10-22 2020-10-19 Agente trombolitico para trombos intravasculares. MX2022004698A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190131585A KR102277471B1 (ko) 2019-10-22 2019-10-22 '혈관내 혈전' 용해제
PCT/KR2020/014217 WO2021080262A1 (ko) 2019-10-22 2020-10-19 '혈관내 혈전' 용해제

Publications (1)

Publication Number Publication Date
MX2022004698A true MX2022004698A (es) 2022-08-04

Family

ID=75619470

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022004698A MX2022004698A (es) 2019-10-22 2020-10-19 Agente trombolitico para trombos intravasculares.

Country Status (9)

Country Link
US (1) US20220362355A1 (es)
EP (1) EP4050105A4 (es)
JP (1) JP7427084B2 (es)
KR (1) KR102277471B1 (es)
CN (1) CN114585735A (es)
BR (1) BR112022007123A2 (es)
CA (1) CA3155130A1 (es)
MX (1) MX2022004698A (es)
WO (1) WO2021080262A1 (es)

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3855065A (en) 1972-10-30 1974-12-17 Baxter Laboratories Inc Production of streptokinase
CH643297A5 (de) 1978-06-30 1984-05-30 Alpha Patent Ltd Verfahren zur reindarstellung von urokinase.
FI831484L (fi) 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US5185259A (en) 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
AU576047B2 (en) 1985-01-14 1988-08-11 Shiseido Company Ltd. Fibrinophilic urokinase complex and process for its preparation
GB8623823D0 (en) 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots
US5011686A (en) 1987-09-21 1991-04-30 Creative Biomolecules, Inc. Thrombus specific conjugates
EP0828003A3 (en) * 1996-09-06 2003-01-15 SmithKline Beecham plc Human serine protease
AU7476198A (en) * 1997-05-09 1998-11-27 General Hospital Corporation, The Cell proliferation related genes
KR20010043127A (ko) * 1998-04-28 2001-05-25 액시스 파마슈티컬스 인코포레이티드 인슐린 유사 성장 인자 결합 단백질을 선택적으로분해시킬 수 있는 세린 프로테아제
US6759042B2 (en) 1999-06-04 2004-07-06 Thrombotech Ltd Use of cross-linked, covalently bound urokinase plasminogen activator (scuPA)-urokinase plasminogen activator receptor (suPAR) complex as a fibrinolytic agent
US7105327B1 (en) 2001-06-15 2006-09-12 Bharat Biotech International, Ltd. Recombinant streptokinase
US7132523B2 (en) * 2002-07-03 2006-11-07 Ortho-Mcneil Pharmaceutical, Inc. Human PRSS11-Like S2 serine protease and uses thereof
WO2005030256A1 (ja) * 2003-09-30 2005-04-07 Daiichi Pharmaceutical Co., Ltd. ＳＨＣ３、ＡＴＦ６またはＣＲＥＢＬ１のＨｔｒＡ２による分解を阻害することによる神経細胞死阻害および神経変性疾患の改善方法
JP2005154399A (ja) 2003-11-24 2005-06-16 Nara Institute Of Science & Technology セリンプロテアーゼＨｔｒＡの使用
CN101417126B (zh) * 2008-12-10 2011-07-27 中国科学技术大学 Omi蛋白及其编码基因的一种新用途
AU2014236947A1 (en) * 2013-03-15 2015-09-03 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
KR102055390B1 (ko) * 2017-01-06 2019-12-12 경북대학교 산학협력단 혈전-표적성 펩타이드, 페리틴 단편 및 혈전 용해성 펩타이드를 포함하는 융합 펩타이드 및 이의 용도
WO2018183213A1 (en) * 2017-03-27 2018-10-04 The Schepens Eye Research Institute, Inc. Blood biomarkers and diagnostic methods for small vessel diseases

Also Published As

Publication number Publication date
KR20210047690A (ko) 2021-04-30
CA3155130A1 (en) 2021-04-29
JP7427084B2 (ja) 2024-02-02
EP4050105A4 (en) 2023-12-06
JP2022551936A (ja) 2022-12-14
CN114585735A (zh) 2022-06-03
WO2021080262A1 (ko) 2021-04-29
KR102277471B1 (ko) 2021-07-14
EP4050105A1 (en) 2022-08-31
US20220362355A1 (en) 2022-11-17
BR112022007123A2 (pt) 2022-07-05

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