MX2022001264A - Compuesto de urea para antagonizar el receptor del acido lisofosfatidico tipo 1. - Google Patents

Compuesto de urea para antagonizar el receptor del acido lisofosfatidico tipo 1.

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Publication number
MX2022001264A
MX2022001264A MX2022001264A MX2022001264A MX2022001264A MX 2022001264 A MX2022001264 A MX 2022001264A MX 2022001264 A MX2022001264 A MX 2022001264A MX 2022001264 A MX2022001264 A MX 2022001264A MX 2022001264 A MX2022001264 A MX 2022001264A
Authority
MX
Mexico
Prior art keywords
antagonizing
urea compound
lpa1 receptor
lpa1
receptor
Prior art date
Application number
MX2022001264A
Other languages
English (en)
Inventor
Shoichi Kuroda
Yuji Ito
Yuki Kobayashi
Kanako Hatanaka
Fumito Uneuchi
Yuko Uehara
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of MX2022001264A publication Critical patent/MX2022001264A/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C275/18—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
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Abstract

La presente invención proporciona un compuesto representado por la fórmula [I] que tiene una acción antagonista del receptor del LPA1, o una sal farmacéuticamente aceptable del mismo; [Fórmula química 1] (ver Fórmula).
MX2022001264A 2019-07-30 2020-07-29 Compuesto de urea para antagonizar el receptor del acido lisofosfatidico tipo 1. MX2022001264A (es)

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PCT/JP2020/029003 WO2021020429A1 (ja) 2019-07-30 2020-07-29 Ｌｐａ１受容体を拮抗するウレア化合物

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KR20220101137A (ko) 2019-11-15 2022-07-19 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제로서의 트라이아졸 카르바메이트 피리딜 설폰아미드 및 이의 용도
CA3176526A1 (en) * 2020-04-29 2021-11-04 Idorsia Pharmaceuticals Ltd Spirourea derivatives
CA3183097A1 (en) 2020-06-03 2021-12-09 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
JP2023529369A (ja) 2020-06-03 2023-07-10 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニスト及びそれらの使用
TWI818538B (zh) 2021-05-11 2023-10-11 美商基利科學股份有限公司 Ｌｐａ受體拮抗劑及其用途
US11939318B2 (en) 2021-12-08 2024-03-26 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
TW202342017A (zh) 2022-02-25 2023-11-01 美商洛子峰生物有限公司 用於治療與ｌｐａ受體活性相關的病狀的化合物及組合物

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ATE447970T1 (de) 2001-02-08 2009-11-15 Ono Pharmaceutical Co Mittel zur behandlung von harnwegserkrankungen, umfassend mittel zur kontrolle des lpa-rezeptors
JP4596314B2 (ja) 2002-05-28 2010-12-08 小野薬品工業株式会社 β−アラニン誘導体およびその用途
AU2003241836A1 (en) 2002-10-03 2004-04-23 Ono Pharmaceutical Co., Ltd. Lpa receptor antagonists
JP5048333B2 (ja) * 2003-10-09 2012-10-17 ユニバーシティ オブ テネシー リサーチ ファウンデーション Ｌｐａ受容体アゴニストおよびアンタゴニストならびに使用法
EP1695955B1 (en) 2003-12-19 2011-10-12 Ono Pharmaceutical Co., Ltd. Compounds having lysophosphatidic acid receptor antagonism and uses thereof
EP2462128B1 (en) * 2009-08-04 2016-09-21 Amira Pharmaceuticals, Inc. Compounds as lysophosphatidic acid receptor antagonists
GB2474120B (en) * 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
WO2014104372A1 (ja) * 2012-12-28 2014-07-03 宇部興産株式会社 ハロゲン置換へテロ環化合物
EP3004052B1 (en) 2013-05-30 2018-04-18 Syngenta Limited Herbicidally active (alkynyl-phenyl)-substituted cyclic dione compounds and derivatives thereof
GB201314926D0 (en) 2013-08-20 2013-10-02 Takeda Pharmaceutical Novel Compounds
RU2689315C2 (ru) * 2014-06-27 2019-05-27 Убе Индастриз, Лтд. Соль гетероциклического соединения, замещенного галогеном
AR108185A1 (es) 2016-04-06 2018-07-25 Abbvie Inc Amidas terciarias y método para su uso
AR108838A1 (es) 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
EA202091506A1 (ru) * 2017-12-19 2020-09-22 Бристол-Маерс Сквибб Компани Триазол n-связанные карбамоил циклогексильные кислоты в качестве антагонистов lpa

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CA3148244A1 (en) 2021-02-04
ZA202201503B (en) 2023-11-29
AU2020323429A1 (en) 2022-02-17
WO2021020429A1 (ja) 2021-02-04
EP4008405A1 (en) 2022-06-08
TW202120474A (zh) 2021-06-01
JPWO2021020429A1 (ja) 2021-12-09
CN114206832A (zh) 2022-03-18
IL289951A (en) 2022-03-01
EP4008405A4 (en) 2023-08-30
BR112022000598A2 (pt) 2022-03-03
KR20220039718A (ko) 2022-03-29
JP7173350B2 (ja) 2022-11-16

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