MX2021015271A - Uso de moleculas biespecificas de union a antigeno que se unen a psma y cd3 en combinacion con la estimulacion conjunta de 4-1bb. - Google Patents

Uso de moleculas biespecificas de union a antigeno que se unen a psma y cd3 en combinacion con la estimulacion conjunta de 4-1bb.

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Publication number
MX2021015271A
MX2021015271A MX2021015271A MX2021015271A MX2021015271A MX 2021015271 A MX2021015271 A MX 2021015271A MX 2021015271 A MX2021015271 A MX 2021015271A MX 2021015271 A MX2021015271 A MX 2021015271A MX 2021015271 A MX2021015271 A MX 2021015271A
Authority
MX
Mexico
Prior art keywords
binding molecules
bispecific antigen
antigen
psma
combination
Prior art date
Application number
MX2021015271A
Other languages
English (en)
Spanish (es)
Inventor
Jessica R Kirshner
Alison Crawford
Danica Chiu
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2021015271A publication Critical patent/MX2021015271A/es

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    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K—PEPTIDES
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
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  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
MX2021015271A 2019-06-21 2020-06-19 Uso de moleculas biespecificas de union a antigeno que se unen a psma y cd3 en combinacion con la estimulacion conjunta de 4-1bb. MX2021015271A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962864999P 2019-06-21 2019-06-21
PCT/US2020/038786 WO2020257681A1 (en) 2019-06-21 2020-06-19 Use of bispecific antigen-binding molecules that bind psma and cd3 in combination with 4-1bb co-stimulation

Publications (1)

Publication Number Publication Date
MX2021015271A true MX2021015271A (es) 2022-01-18

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MX2021015271A MX2021015271A (es) 2019-06-21 2020-06-19 Uso de moleculas biespecificas de union a antigeno que se unen a psma y cd3 en combinacion con la estimulacion conjunta de 4-1bb.

Country Status (12)

Country Link
US (1) US20200399372A1 (enExample)
EP (1) EP3986933A1 (enExample)
JP (2) JP7743313B2 (enExample)
KR (1) KR20220024594A (enExample)
CN (2) CN118526580A (enExample)
AU (1) AU2020296181A1 (enExample)
CA (1) CA3139827A1 (enExample)
IL (1) IL289041A (enExample)
MA (1) MA56515A (enExample)
MX (1) MX2021015271A (enExample)
WO (1) WO2020257681A1 (enExample)
ZA (1) ZA202109048B (enExample)

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Publication number Priority date Publication date Assignee Title
KR20240139065A (ko) * 2022-02-07 2024-09-20 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Psma 및 cd3에 특이적으로 결합하는 항원 결합 분자 및 이들의 의약적 용도
WO2023224912A1 (en) * 2022-05-16 2023-11-23 Regeneron Pharmaceuticals, Inc. Methods of treating metastatic castration-resistant prostate cancer with bispecific anti-psma x anti-cd3 antibodies alone or in combination with anti-pd-1 antibodies
WO2025070636A1 (ja) * 2023-09-26 2025-04-03 ブライトパス・バイオ株式会社 Ｃｄ３９を標的とする多重特異性抗原結合性分子
CN118086511B (zh) * 2024-04-25 2024-07-09 中国中医科学院望京医院(中国中医科学院骨伤科研究所) 胃粘膜肠上皮化生亚型生物标志物folh1及其应用

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RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
MY192182A (en) 2009-06-26 2022-08-04 Regeneron Pharma Readily isolated bispecific antibodies with native immunoglobulin format
JO3182B1 (ar) 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
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