MX2021014439A - Metodos y aparatos para microorganoesferas derivadas de pacientes. - Google Patents
Metodos y aparatos para microorganoesferas derivadas de pacientes.Info
- Publication number
- MX2021014439A MX2021014439A MX2021014439A MX2021014439A MX2021014439A MX 2021014439 A MX2021014439 A MX 2021014439A MX 2021014439 A MX2021014439 A MX 2021014439A MX 2021014439 A MX2021014439 A MX 2021014439A MX 2021014439 A MX2021014439 A MX 2021014439A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- patient
- organospheres
- apparatuses
- derived micro
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000011338 personalized therapy Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0012—Cell encapsulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/01—Drops
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/16—Particles; Beads; Granular material; Encapsulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/50—Soluble polymers, e.g. polyethyleneglycol [PEG]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Physiology (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962853219P | 2019-05-28 | 2019-05-28 | |
| PCT/US2020/026275 WO2020242594A1 (en) | 2019-05-28 | 2020-04-01 | Methods and apparatuses for patient-derived micro-organospheres |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021014439A true MX2021014439A (es) | 2022-05-19 |
Family
ID=73549270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021014439A MX2021014439A (es) | 2019-05-28 | 2020-04-01 | Metodos y aparatos para microorganoesferas derivadas de pacientes. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11555180B2 (https=) |
| EP (1) | EP3976064A4 (https=) |
| JP (1) | JP2022534778A (https=) |
| CN (1) | CN116157134A (https=) |
| AU (1) | AU2020283390A1 (https=) |
| CA (1) | CA3142113A1 (https=) |
| IL (1) | IL288370A (https=) |
| MX (1) | MX2021014439A (https=) |
| SG (1) | SG11202113122SA (https=) |
| WO (1) | WO2020242594A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114410466A (zh) * | 2020-04-01 | 2022-04-29 | 沈西凌 | 用于个性化癌症治疗的精确药物筛选 |
| JP2023550651A (ja) * | 2020-11-24 | 2023-12-04 | デューク ユニバーシティ | 液滴オルガノイドに基づく癌免疫学アッセイ及び其れを使用する方法 |
| DE102022100146B4 (de) | 2022-01-04 | 2023-11-30 | Precomb Therapeutics Ag | Verfahren zur analyse von personalisierten anti-krebs-wirkstoffen in zellkulturen |
| EP4514990A4 (en) * | 2022-04-29 | 2026-05-06 | Xilis Inc | Methods and apparatuses for testing hepatocyte toxicity using microorganospheres |
| TW202407098A (zh) * | 2022-05-03 | 2024-02-16 | 美商西利斯股份有限公司 | 衍生自患者之微器官球體(mos)實現臨床精準腫瘤學 |
| JP2025528207A (ja) | 2022-08-17 | 2025-08-26 | ザイリス， インク． | 画像に基づく微小有機球体薬剤アッセイ |
| CN120225691A (zh) * | 2022-09-07 | 2025-06-27 | 西利斯公司 | 多发性骨髓瘤微器官球体 |
| US11999934B2 (en) | 2022-10-11 | 2024-06-04 | Xilis, Inc. | Integrated microfluidic system for generation of MicroOrganoSpheres (MOS) |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| ES2157225T3 (es) | 1992-10-09 | 2001-08-16 | Advanced Tissue Sciences Inc | Celulas hepaticas de reserva. |
| CA2545482A1 (en) | 2003-11-10 | 2005-05-26 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
| US7759111B2 (en) * | 2004-08-27 | 2010-07-20 | The Regents Of The University Of California | Cell encapsulation microfluidic device |
| AU2006206426B2 (en) | 2005-01-20 | 2012-03-15 | The Regents Of The University Of California | Cellular microarrays for screening differentiation factors |
| US20070134209A1 (en) * | 2005-12-12 | 2007-06-14 | Metafluidics, Inc. | Cellular encapsulation for self-assembly of engineered tissue |
| US20120135875A1 (en) | 2008-02-29 | 2012-05-31 | Bristol-Myers Squibb Company | Methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators |
| WO2009126524A2 (en) * | 2008-04-08 | 2009-10-15 | Massachusetts Institute Of Technology | Three-dimensional microfluidic platforms and methods of use thereof |
| WO2012018982A2 (en) * | 2010-08-05 | 2012-02-09 | Tufts Medical Center, Inc. | Methods and kits for modulating tumor invasiveness and metastatic potential |
| GB201105226D0 (en) * | 2011-03-29 | 2011-05-11 | Univ Leiden | Methods |
| AU2012262139B2 (en) * | 2011-06-02 | 2017-02-23 | Children's Medical Center Corporation | Methods and uses for ex vivo tissue culture systems |
| US9334473B2 (en) * | 2012-08-17 | 2016-05-10 | Jelena Vukasinovic | Three dimensional cell culture compositions and methods of use |
| WO2014082096A1 (en) * | 2012-11-26 | 2014-05-30 | The Trustees Of Columbia University In The City Of New York | Method for culture of human and mouse prostate organoids and uses thereof |
| KR102257305B1 (ko) | 2013-03-28 | 2021-05-28 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 미세유동 장치 및 분비물의 다세포 검정법에서의 그의 사용 방법 |
| WO2014197543A1 (en) | 2013-06-04 | 2014-12-11 | University Of Miami | Assays, methods and kits for analyzing sensitivity and resistance to anti-cancer drugs, predicting a cancer patient's prognosis, and personalized treatment strategies |
| US10059921B2 (en) | 2013-08-21 | 2018-08-28 | University Of Louisville Research Foundation, Inc. | Methods of making spheroids including biologically-relevant materials |
| EP3161052A4 (en) * | 2014-06-26 | 2018-03-21 | Northeastern University | Microfluidic device and method for analysis of tumor cell microenvironments |
| EP3242930A4 (en) | 2015-01-07 | 2019-01-16 | Dana-Farber Cancer Institute, Inc. | MICROFLUIDIC CELL CULTURE OF TUMOR CELL SPHEROIDS FROM PATIENTS |
| WO2016145242A1 (en) | 2015-03-11 | 2016-09-15 | Agenus Inc. | Methods and compositions for high throughput screening of biomolecules using gel microdrops |
| CA3003030C (en) * | 2015-10-26 | 2023-12-19 | University Of Wyoming | Methods of generating microparticles and porous hydrogels using microfluidics |
| TWM516858U (zh) | 2015-11-19 | 2016-02-11 | 金鼎聯合科技纖維股份有限公司 | 膠線改良結構 |
| EP3411470A4 (en) | 2016-02-01 | 2019-10-09 | Emulate, Inc. | SYSTEMS AND METHOD FOR BREEDING DARM CELLS IN MICROFLUIDIC DEVICES |
| BR112018075920A2 (pt) * | 2016-06-15 | 2019-03-26 | Mimetas B.V. | dispositivo e métodos de cultura celular |
| KR20190028726A (ko) * | 2016-07-12 | 2019-03-19 | 더 유니버시티 오브 노스캐롤라이나 앳 채플 힐 | 암 진단 및 모델링에 사용하기 위한 바이오매트릭스 스캐폴드 |
| US11180735B2 (en) * | 2016-10-28 | 2021-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods to preserve tumor-stromal interactions in culture and therapeutic predictive applications thereof |
| CN110997900B (zh) * | 2017-07-14 | 2024-06-14 | 多伦多大学管理委员会 | 用于快速产生用于化合物筛选的类器官/球状体的微流体平台 |
| US20220065861A1 (en) | 2017-09-27 | 2022-03-03 | Duke University | Patient specific clinical trials and associated methods of treatment |
| US11166920B2 (en) * | 2017-10-05 | 2021-11-09 | Auburn University | Microfluidics device for fabrication of large, uniform, injectable hydrogel microparticles for cell encapsulation |
| CN111670247B (zh) * | 2017-12-08 | 2024-01-05 | 京诊断株式会社 | 制备癌球状体的方法和选择结直肠癌患者的方法 |
| GB201721615D0 (en) * | 2017-12-21 | 2018-02-07 | Koninklijke Nederlandse Akademie Van Wetenschappen | Immune cell organoid co-cultures |
| CN110004111B (zh) * | 2019-04-22 | 2021-10-08 | 清华-伯克利深圳学院筹备办公室 | 一种类器官球体的制备方法 |
-
2020
- 2020-04-01 MX MX2021014439A patent/MX2021014439A/es unknown
- 2020-04-01 SG SG11202113122SA patent/SG11202113122SA/en unknown
- 2020-04-01 EP EP20812521.1A patent/EP3976064A4/en active Pending
- 2020-04-01 US US16/838,010 patent/US11555180B2/en active Active
- 2020-04-01 JP JP2021571518A patent/JP2022534778A/ja active Pending
- 2020-04-01 WO PCT/US2020/026275 patent/WO2020242594A1/en not_active Ceased
- 2020-04-01 CN CN202080006103.2A patent/CN116157134A/zh active Pending
- 2020-04-01 AU AU2020283390A patent/AU2020283390A1/en active Pending
- 2020-04-01 CA CA3142113A patent/CA3142113A1/en active Pending
-
2021
- 2021-11-24 IL IL288370A patent/IL288370A/en unknown
-
2022
- 2022-07-26 US US17/874,136 patent/US20230002737A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3976064A4 (en) | 2023-05-31 |
| WO2020242594A1 (en) | 2020-12-03 |
| US20230002737A1 (en) | 2023-01-05 |
| EP3976064A1 (en) | 2022-04-06 |
| CA3142113A1 (en) | 2020-12-03 |
| JP2022534778A (ja) | 2022-08-03 |
| US20200377861A1 (en) | 2020-12-03 |
| IL288370A (en) | 2022-01-01 |
| US11555180B2 (en) | 2023-01-17 |
| CN116157134A (zh) | 2023-05-23 |
| AU2020283390A1 (en) | 2021-12-23 |
| SG11202113122SA (en) | 2021-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2021014439A (es) | Metodos y aparatos para microorganoesferas derivadas de pacientes. | |
| PH12022550950A1 (en) | Isoindolinone and indazole compounds for the degradation of egfr | |
| ZA202102696B (en) | Anti-b7h3 antibody-exatecan analog conjugate and medicinal use thereof | |
| WO2020187167A8 (en) | Method and apparatus for multiplexing uci | |
| MX2021006564A (es) | Sistemas activos dinamicos acromosomicos. | |
| EP4467171A3 (en) | Systems employing directed fluidics | |
| CR20230581A (es) | Anticuerpos anti-CCR8 y usos de los mismos | |
| PH12022550646A1 (en) | Anti-klk7 antibodies, anti-klk5 antibodies, multispecific anti-klk5/klk7 antibodies, and methods of use | |
| EP3893766A4 (en) | INSTRUMENTS, GUIDES AND RELATED PROCEDURES FOR TOTAL ANKLE REPLACEMENT | |
| SG10201805290YA (en) | System and method for evaluation of used components | |
| WO2020033527A3 (en) | Recombinant biologically contained filovirus vaccine | |
| EP4060925A3 (en) | Transmitting and receiving a synchronization signal block | |
| EP3949256A4 (en) | SECURE COMMUNICATION FOR MEDICAL DEVICES | |
| EP4340287A3 (en) | Demodulation reference signal configuration | |
| PH12020550137A1 (en) | Radio transmission device and radio reception device | |
| ZA202206670B (en) | Anti-ly6g6d antibodies and methods of use | |
| MX2020001844A (es) | Metodos y sistema para aparatos dentales homogeneos. | |
| SG11202107476YA (en) | Methods and devices for configuring, sending and receiving discovery reference signal (drs) | |
| MX2020004072A (es) | Monitoreo de terapia bajo tratamiento con un aglutinante anti-adrenomodulina (adm). | |
| PH12021550413A1 (en) | Vitamin d pediatric dosage forms, methods of making and using | |
| PH12022552371A1 (en) | Anti-interleukin-33 antibodies and uses thereof | |
| MY200753A (en) | Terminal apparatus, control apparatus, and communication control method | |
| GB2557456A (en) | Systems, methods and computer program products for controlling the audio levels of multiple simultaneous communication channels | |
| WO2020018751A9 (en) | Methods and kits of using an implant for tissue repair | |
| WO2020068196A3 (en) | Proteins that inhibit cas12a (cpf1), a crispr-cas nuclease |