MX2021012544A - Compuestos novedosos y composiciones farmaceuticas de los mismos para el tratamiento de enfermedades renales. - Google Patents
Compuestos novedosos y composiciones farmaceuticas de los mismos para el tratamiento de enfermedades renales.Info
- Publication number
- MX2021012544A MX2021012544A MX2021012544A MX2021012544A MX2021012544A MX 2021012544 A MX2021012544 A MX 2021012544A MX 2021012544 A MX2021012544 A MX 2021012544A MX 2021012544 A MX2021012544 A MX 2021012544A MX 2021012544 A MX2021012544 A MX 2021012544A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- pharmaceutical compositions
- novel compounds
- kidney diseases
- prophylaxis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención describe los compuestos de acuerdo con la Fórmula I: (ver Fórmula) En donde R1 es como se define en este documento. La presente invención se refiere a compuestos, métodos para su producción, composiciones farmacéuticas que comprenden los mismos y métodos de tratamiento que usan los mismos, para la profilaxis y/o el tratamiento que pueden ser útiles en la profilaxis y/o el tratamiento de la enfermedad poliquística renal (PKD), mediante la administración del compuesto de la invención.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1905711.6A GB201905711D0 (en) | 2019-04-24 | 2019-04-24 | Novel compounds and pharmaceutical compositions thereof for the treatment of kidney diseases |
PCT/EP2020/061083 WO2020216740A1 (en) | 2019-04-24 | 2020-04-21 | Novel compounds and pharmaceutical compositions thereof for the treatment of kidney diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021012544A true MX2021012544A (es) | 2021-11-12 |
Family
ID=66810218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021012544A MX2021012544A (es) | 2019-04-24 | 2020-04-21 | Compuestos novedosos y composiciones farmaceuticas de los mismos para el tratamiento de enfermedades renales. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220202802A1 (es) |
EP (1) | EP3958863A1 (es) |
JP (1) | JP2022529814A (es) |
KR (1) | KR20220004111A (es) |
CN (1) | CN113727711A (es) |
AU (1) | AU2020263869A1 (es) |
BR (1) | BR112021021117A2 (es) |
CA (1) | CA3137445A1 (es) |
GB (1) | GB201905711D0 (es) |
IL (1) | IL287392A (es) |
MA (1) | MA55752A (es) |
MX (1) | MX2021012544A (es) |
SG (1) | SG11202111739VA (es) |
WO (1) | WO2020216740A1 (es) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7514463B2 (en) * | 2004-08-20 | 2009-04-07 | University Of Kansas | Lonidamine analogues and their use in male contraception and cancer treatment |
US8362031B2 (en) * | 2004-08-20 | 2013-01-29 | University Of Kansas | Lonidamine analogues and treatment of polycystic kidney disease |
US8609661B2 (en) * | 2009-08-10 | 2013-12-17 | The Regents Of The University Of California | Pyrimido-pyrrolo-quinoxalinedione inhibitors of cystic fibrosis transmembrane conductance regulator protein and uses therefor |
TWI633887B (zh) * | 2012-05-31 | 2018-09-01 | 大塚製藥股份有限公司 | 用於預防及/或治療多囊性腎臟病之藥物 |
US10174012B2 (en) * | 2014-11-04 | 2019-01-08 | The University Of Kansas | LKB1-AMPK activators for therapeutic use in polycystic kidney disease |
CA3001094A1 (en) | 2015-10-09 | 2017-04-13 | Abbvie S.A.R.L. | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and their use |
AU2016333856C1 (en) | 2015-10-09 | 2021-12-09 | AbbVie Global Enterprises Ltd. | N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use |
CN108602816A (zh) * | 2015-10-09 | 2018-09-28 | 艾伯维公司 | 用于治疗囊性纤维化的新颖化合物 |
JP2020525446A (ja) * | 2017-06-21 | 2020-08-27 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 常染色体優性多発性嚢胞腎疾患を治療するための嚢胞性線維症膜貫通コンダクタンス制御因子の調節因子 |
-
2019
- 2019-04-24 GB GBGB1905711.6A patent/GB201905711D0/en not_active Ceased
-
2020
- 2020-04-21 EP EP20721493.3A patent/EP3958863A1/en active Pending
- 2020-04-21 AU AU2020263869A patent/AU2020263869A1/en not_active Abandoned
- 2020-04-21 US US17/605,623 patent/US20220202802A1/en active Pending
- 2020-04-21 KR KR1020217038004A patent/KR20220004111A/ko unknown
- 2020-04-21 JP JP2021562854A patent/JP2022529814A/ja active Pending
- 2020-04-21 CN CN202080030725.9A patent/CN113727711A/zh active Pending
- 2020-04-21 WO PCT/EP2020/061083 patent/WO2020216740A1/en unknown
- 2020-04-21 CA CA3137445A patent/CA3137445A1/en active Pending
- 2020-04-21 MA MA055752A patent/MA55752A/fr unknown
- 2020-04-21 BR BR112021021117A patent/BR112021021117A2/pt not_active Application Discontinuation
- 2020-04-21 SG SG11202111739VA patent/SG11202111739VA/en unknown
- 2020-04-21 MX MX2021012544A patent/MX2021012544A/es unknown
-
2021
- 2021-10-19 IL IL287392A patent/IL287392A/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20220004111A (ko) | 2022-01-11 |
BR112021021117A2 (pt) | 2021-12-14 |
JP2022529814A (ja) | 2022-06-24 |
CN113727711A (zh) | 2021-11-30 |
CA3137445A1 (en) | 2020-10-29 |
SG11202111739VA (en) | 2021-11-29 |
US20220202802A1 (en) | 2022-06-30 |
AU2020263869A1 (en) | 2021-12-23 |
WO2020216740A1 (en) | 2020-10-29 |
EP3958863A1 (en) | 2022-03-02 |
GB201905711D0 (en) | 2019-06-05 |
MA55752A (fr) | 2022-03-02 |
IL287392A (en) | 2021-12-01 |
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