MX2021011983A - Compuestos de neuregulina-4 y metodos de uso. - Google Patents
Compuestos de neuregulina-4 y metodos de uso.Info
- Publication number
- MX2021011983A MX2021011983A MX2021011983A MX2021011983A MX2021011983A MX 2021011983 A MX2021011983 A MX 2021011983A MX 2021011983 A MX2021011983 A MX 2021011983A MX 2021011983 A MX2021011983 A MX 2021011983A MX 2021011983 A MX2021011983 A MX 2021011983A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- neuregulin
- methods
- nrg4
- nrg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a compuestos de neuregulina (NRG) 4 y métodos de tratamiento con compuestos de NRG4.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962827386P | 2019-04-01 | 2019-04-01 | |
PCT/US2020/025921 WO2020205840A1 (en) | 2019-04-01 | 2020-03-31 | Neuregulin-4 compounds and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021011983A true MX2021011983A (es) | 2021-11-03 |
Family
ID=70465394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021011983A MX2021011983A (es) | 2019-04-01 | 2020-03-31 | Compuestos de neuregulina-4 y metodos de uso. |
Country Status (23)
Country | Link |
---|---|
US (2) | US11242370B2 (es) |
EP (1) | EP3947428A1 (es) |
JP (1) | JP7036953B2 (es) |
KR (1) | KR20210134699A (es) |
CN (1) | CN113677699A (es) |
AR (1) | AR121035A1 (es) |
AU (1) | AU2020252184B2 (es) |
BR (1) | BR112021017670A2 (es) |
CA (2) | CA3132135A1 (es) |
CL (1) | CL2021002455A1 (es) |
CO (1) | CO2021012807A2 (es) |
CR (1) | CR20210474A (es) |
DO (1) | DOP2021000194A (es) |
EA (1) | EA202192288A1 (es) |
EC (1) | ECSP21072840A (es) |
IL (1) | IL286697A (es) |
JO (1) | JOP20210264A1 (es) |
MA (1) | MA55532A (es) |
MX (1) | MX2021011983A (es) |
PE (1) | PE20212326A1 (es) |
SG (1) | SG11202110484VA (es) |
TW (1) | TWI787596B (es) |
WO (1) | WO2020205840A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017058828A1 (en) | 2015-09-28 | 2017-04-06 | Children's Hospital Los Angeles | Methods for treating diseases mediated by erbb4-positive pro-inflammatory macrophages |
AR121035A1 (es) * | 2019-04-01 | 2022-04-13 | Lilly Co Eli | Compuestos de neuregulina-4 y métodos de uso |
WO2023150693A2 (en) * | 2022-02-03 | 2023-08-10 | Avexegen Therapeutics, Inc. | Neuregulin-4 analogs and methods of using thereof in disease treatment |
WO2023230491A1 (en) | 2022-05-25 | 2023-11-30 | Eli Lilly And Company | Methods of using neuregulin-4 compounds |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7115554B1 (en) | 1993-05-06 | 2006-10-03 | Acorda Therapeutics, Inc. | Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III |
US5530109A (en) | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
US7037888B1 (en) | 1992-04-03 | 2006-05-02 | Acorda Therapeutics, Inc. | Methods for treating muscle diseases and disorders |
WO1999018976A1 (en) | 1997-10-14 | 1999-04-22 | Cambridge Neuroscience, Inc. | Therapeutic methods comprising use of a neuregulin |
AUPP785098A0 (en) | 1998-12-21 | 1999-01-21 | Victor Chang Cardiac Research Institute, The | Treatment of heart disease |
US6635249B1 (en) | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
US6825333B1 (en) | 1999-08-20 | 2004-11-30 | Chiron Corporation | EGFH2 genes and gene products |
WO2001014415A2 (en) | 1999-08-20 | 2001-03-01 | Chiron Corporation | Egfh2 genes and gene products |
US7094882B2 (en) | 2000-04-21 | 2006-08-22 | Yeda Research And Development Co. Ltd. | Growth factor which acts through erb b-4 rtk |
US6544759B1 (en) | 2000-04-21 | 2003-04-08 | Yeda Research And Development Co. Ltd | Polynucleotides encoding a novel growth factor which acts through ErbB-4 kinase receptor tyrosine |
EP2357004B1 (en) | 2000-05-23 | 2016-10-12 | CeNeS Pharmaceuticals, Inc. | NRG-2 nucleic acid molecules, polypeptides and diagnostic and therapeutical methods |
EP1421113A4 (en) | 2001-08-03 | 2005-04-13 | Commw Scient Ind Res Org | SCREENING METHODS BASED ON CRYSTALLINE EGF RECEPTOR STRUCTURE |
WO2003025142A2 (en) | 2001-09-16 | 2003-03-27 | Nuvelo, Inc. | Novel nucleic acids and secreted polypeptides |
CN1498656A (zh) * | 2002-11-08 | 2004-05-26 | 上海泽生科技开发有限公司 | 神经调节蛋白用于心肌梗死治疗的方法和组合物 |
AU2002304965A1 (en) | 2002-05-24 | 2003-12-12 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
EP1660628A4 (en) | 2003-08-19 | 2010-03-31 | Agos Biotech Ltd | ERBB LIGAND SPLICE VARIANTS, COMPOSITIONS AND USES THEREOF |
US20070213264A1 (en) | 2005-12-02 | 2007-09-13 | Mingdong Zhou | Neuregulin variants and methods of screening and using thereof |
CN101394861A (zh) * | 2005-12-30 | 2009-03-25 | 上海泽生科技开发有限公司 | 纽兰格林持续给药能改善心脏功能 |
ES2530526T3 (es) | 2005-12-30 | 2015-03-03 | Zensun Shanghai Science And Technology Ltd | Liberación extendida de neurregulina para mejorar la función cardíaca |
AU2007257683A1 (en) * | 2006-06-12 | 2007-12-21 | Symphogen A/S | Pan-cell surface receptor- specific therapeutics |
ES2315110B1 (es) | 2006-07-14 | 2009-12-30 | Universidad De Barcelona | Compuestos para el tratamiento de enfermedades relacionadas con la resistencia a la insulina. |
CN101310779A (zh) * | 2007-05-25 | 2008-11-26 | 上海泽生科技开发有限公司 | 包含神经调节蛋白的装置及药物制剂 |
CN103432681A (zh) * | 2007-05-25 | 2013-12-11 | 上海泽生科技开发有限公司 | 包含神经调节蛋白的药物制剂及装置 |
US20090156488A1 (en) | 2007-09-12 | 2009-06-18 | Zensun (Shanghai) Science & Technology Limited | Use of neuregulin for organ preservation |
CN101397337A (zh) * | 2007-09-25 | 2009-04-01 | 上海泽生科技开发有限公司 | 神经调节蛋白突变体及其用途 |
ES2664394T3 (es) | 2008-07-17 | 2018-04-19 | Acorda Therapeutics, Inc. | Dosificación terapéutica de una neuregulina o de una subsecuencia de la misma para el tratamiento o la profilaxis de la insuficiencia cardiaca |
CA2734766A1 (en) | 2008-08-15 | 2010-02-18 | Acorda Therapeutics, Inc. | Compositions and methods for treatment during non-acute periods following cns neurological injury |
WO2010060266A1 (en) | 2008-11-28 | 2010-06-03 | Zensun (Shanghai) Science & Technology Limited | Neuregulin and cardiac stem cells |
US8609620B2 (en) | 2008-11-28 | 2013-12-17 | Zensun (Shanghai) Science & Technology Ltd. | Neuregulin peptides and their use |
JP2013503110A (ja) | 2009-06-09 | 2013-01-31 | ゼンサン (シャンハイ) サイエンス アンド テクノロジー リミテッド | ニューレグリンに基づく心不全の治療方法 |
WO2010142141A1 (en) | 2009-06-09 | 2010-12-16 | Zensun (Shanghai) Science & Technology Limited | Neuregulin based methods for treating heart failure |
US8889625B2 (en) | 2009-07-10 | 2014-11-18 | Northwestern University | Cardioprotective role of hepatic cells and hepatocyte secretory factors in myocardial ischemia |
US20120121557A1 (en) | 2009-07-22 | 2012-05-17 | Children's Medical Center Corporation | Neuregulin induced proliferation of cardiomyocytes |
JP6096262B2 (ja) | 2009-08-25 | 2017-03-15 | ゼンサン (シャンハイ) サイエンス アンド テクノロジー,シーオー.,エルティーディー. | ニューレグリンに基づく心不全の治療方法 |
CN102139095A (zh) | 2010-01-29 | 2011-08-03 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物 |
US9029328B2 (en) | 2010-03-24 | 2015-05-12 | The Brigham And Women's Hospital, Inc. | Methods for cardioprotection and cardioregeneration with dimers of EGF family ligands |
ES2745644T3 (es) | 2011-08-15 | 2020-03-03 | Los Angeles Childrens Hospital | Uso de neuregulina-4 para el tratamiento de la enfermedad inflamatoria intestinal y la enterocolitis necrotizante |
WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun (Shanghai)Science & Technology Limited | Compositions and methods for treating heart failure |
US8748131B2 (en) | 2012-09-26 | 2014-06-10 | Morehouse School Of Medicine | Chimeric neuregulins and method of making and use thereof |
WO2014051567A1 (en) | 2012-09-26 | 2014-04-03 | Morehouse School Of Medicine | Chimeric neuregulins and method of making and use thereof |
WO2014056121A1 (en) | 2012-10-08 | 2014-04-17 | Zensun (Shanghai) Science & Technology Limited | Compositions and methods for treating heart failure in diabetic patients |
US20160129084A1 (en) | 2013-03-06 | 2016-05-12 | Acorda Therapeutics, Inc. | Therapeutic Dosing of a Neuregulin or a Fragment Thereof for Treatment or Prophylaxis of Heart Failure |
ES2751391T3 (es) | 2013-03-21 | 2020-03-31 | Univ Michigan Regents | Procedimientos de tratamiento de trastornos metabólicos |
AU2014270882B2 (en) | 2013-05-22 | 2019-03-14 | Zensun (Shanghai) Science & Technology, Co. Ltd. | Extended release of neuregulin for treating heart failure |
CN104211799B (zh) | 2013-05-29 | 2017-12-26 | 成都渊源生物科技有限公司 | 人源egf结构域蛋白及其应用 |
CN104758922A (zh) | 2014-01-03 | 2015-07-08 | 上海泽生科技开发有限公司 | 纽兰格林制剂的配方 |
US9352923B2 (en) | 2014-02-26 | 2016-05-31 | Eastman Kodak Company | Air shoe with roller providing lateral constraint |
WO2015158743A1 (en) | 2014-04-15 | 2015-10-22 | Universiteit Antwerpen | Treatment of nephropathy |
CN105497876B (zh) | 2014-09-24 | 2021-01-15 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 |
CN105561298A (zh) | 2014-10-17 | 2016-05-11 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
US20170333529A1 (en) | 2015-01-20 | 2017-11-23 | Universiteit Antwerpen | Neuregulin in the treatment of fibrotic disorders |
US10017574B2 (en) | 2015-05-07 | 2018-07-10 | Yeda Research And Development Co. Ltd. | Methods, kits and devices for promoting cardiac regeneration |
WO2017058828A1 (en) | 2015-09-28 | 2017-04-06 | Children's Hospital Los Angeles | Methods for treating diseases mediated by erbb4-positive pro-inflammatory macrophages |
CN113166218A (zh) | 2018-04-11 | 2021-07-23 | 信立泰生物医药公司 | 人神经调节蛋白-1(nrg-1)重组融合蛋白组合物和其使用方法 |
AR121035A1 (es) * | 2019-04-01 | 2022-04-13 | Lilly Co Eli | Compuestos de neuregulina-4 y métodos de uso |
-
2020
- 2020-03-25 AR ARP200100818A patent/AR121035A1/es unknown
- 2020-03-26 TW TW109110143A patent/TWI787596B/zh active
- 2020-03-31 CN CN202080026858.9A patent/CN113677699A/zh active Pending
- 2020-03-31 CR CR20210474A patent/CR20210474A/es unknown
- 2020-03-31 JP JP2020573148A patent/JP7036953B2/ja active Active
- 2020-03-31 JO JOP/2021/0264A patent/JOP20210264A1/ar unknown
- 2020-03-31 PE PE2021001542A patent/PE20212326A1/es unknown
- 2020-03-31 KR KR1020217031066A patent/KR20210134699A/ko not_active Application Discontinuation
- 2020-03-31 CA CA3132135A patent/CA3132135A1/en active Pending
- 2020-03-31 AU AU2020252184A patent/AU2020252184B2/en active Active
- 2020-03-31 US US16/835,787 patent/US11242370B2/en active Active
- 2020-03-31 CA CA3223554A patent/CA3223554A1/en active Pending
- 2020-03-31 EA EA202192288A patent/EA202192288A1/ru unknown
- 2020-03-31 MX MX2021011983A patent/MX2021011983A/es unknown
- 2020-03-31 MA MA055532A patent/MA55532A/fr unknown
- 2020-03-31 BR BR112021017670A patent/BR112021017670A2/pt unknown
- 2020-03-31 SG SG11202110484VA patent/SG11202110484VA/en unknown
- 2020-03-31 WO PCT/US2020/025921 patent/WO2020205840A1/en active Application Filing
- 2020-03-31 EP EP20722024.5A patent/EP3947428A1/en active Pending
-
2021
- 2021-09-21 CL CL2021002455A patent/CL2021002455A1/es unknown
- 2021-09-21 DO DO2021000194A patent/DOP2021000194A/es unknown
- 2021-09-26 IL IL286697A patent/IL286697A/en unknown
- 2021-09-28 CO CONC2021/0012807A patent/CO2021012807A2/es unknown
- 2021-09-30 EC ECSENADI202172840A patent/ECSP21072840A/es unknown
- 2021-12-22 US US17/559,430 patent/US20220112255A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN113677699A (zh) | 2021-11-19 |
TWI787596B (zh) | 2022-12-21 |
PE20212326A1 (es) | 2021-12-14 |
ECSP21072840A (es) | 2021-11-18 |
TW202104251A (zh) | 2021-02-01 |
SG11202110484VA (en) | 2021-10-28 |
AU2020252184B2 (en) | 2022-12-08 |
AR121035A1 (es) | 2022-04-13 |
MA55532A (fr) | 2022-02-09 |
EP3947428A1 (en) | 2022-02-09 |
CO2021012807A2 (es) | 2021-10-29 |
BR112021017670A2 (pt) | 2021-11-16 |
IL286697A (en) | 2021-10-31 |
CR20210474A (es) | 2021-10-13 |
US20200354421A1 (en) | 2020-11-12 |
JP7036953B2 (ja) | 2022-03-15 |
EA202192288A1 (ru) | 2022-01-21 |
JP2021522314A (ja) | 2021-08-30 |
CL2021002455A1 (es) | 2022-05-27 |
US11242370B2 (en) | 2022-02-08 |
DOP2021000194A (es) | 2021-10-31 |
US20220112255A1 (en) | 2022-04-14 |
CA3132135A1 (en) | 2020-10-08 |
KR20210134699A (ko) | 2021-11-10 |
WO2020205840A1 (en) | 2020-10-08 |
JOP20210264A1 (ar) | 2023-01-30 |
CA3223554A1 (en) | 2020-10-08 |
AU2020252184A1 (en) | 2021-10-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JOP20210264A1 (ar) | مركبات نورجولين-4 وطرق استخدامها | |
MX2020013853A (es) | Compuestos innovadores. | |
MX2022012474A (es) | Compuestos y usos de estos. | |
MX2020006191A (es) | Bacteriocinas terapeuticas. | |
ZA202207804B (en) | Compounds and uses thereof | |
MX2022001004A (es) | Inhibidores de enzimas. | |
MX2022009369A (es) | Compuestos y usos de estos. | |
MX2021012659A (es) | Composiciones de seda para el cuidado del cabello. | |
MX2022009308A (es) | Compuestos y usos de estos. | |
MX2022007841A (es) | Degradadores del regulador dependiente de actina asociado a la matriz relacionado con el complejo switch/sacarosa no fermentable de la subfamilia a de la cromatina (smarca)y usos de los mismos. | |
MX2022003037A (es) | Compuestos antibacterianos. | |
PH12021550122A1 (en) | Solubilized apyrases, methods and use | |
JOP20200291A1 (ar) | معدلات التعبير عن apol1 | |
MX2022009367A (es) | Compuestos y usos de estos. | |
MX2022000811A (es) | Inhibidores de enzimas. | |
MX2021010665A (es) | Metodos de tratamiento de amiloidosis al. | |
MX2021006977A (es) | Anellosomas y metodos de uso. | |
MX2023005436A (es) | Compuestos y usos de estos. | |
AU2020378127A8 (en) | Compounds as CD73 inhibitors | |
PH12020551331A1 (en) | Treatment and prevention of pre-eclampsia | |
MX2022003030A (es) | Tratamiento de afecciones distintas de la esclerosis multiple en pacientes tratados con ofatumumab. | |
WO2021041716A3 (en) | Therapeutic editing to treat cardiomyopathy | |
MX2021014220A (es) | Composiciones para el tratamiento de la perdida del cabello. | |
MX2022003816A (es) | Compuestos antibacterianos. | |
MX2022003814A (es) | Compuestos antibacterianos de 4-quinolinona. |