MX2021011647A - Moduladores del receptor x4 de proteina g relacionado con mas y productos y metodos relacionados. - Google Patents

Moduladores del receptor x4 de proteina g relacionado con mas y productos y metodos relacionados.

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Publication number
MX2021011647A
MX2021011647A MX2021011647A MX2021011647A MX2021011647A MX 2021011647 A MX2021011647 A MX 2021011647A MX 2021011647 A MX2021011647 A MX 2021011647A MX 2021011647 A MX2021011647 A MX 2021011647A MX 2021011647 A MX2021011647 A MX 2021011647A
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MX
Mexico
Prior art keywords
sup
sub
methods
mas
modulators
Prior art date
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MX2021011647A
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English (en)
Inventor
Esther Martinborough
Liming Huang
Adam Yeager
Brandon Selfridge
Marcos Sainz
Marcus Boehm
Original Assignee
Escient Pharmaceuticals Inc
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Application filed by Escient Pharmaceuticals Inc filed Critical Escient Pharmaceuticals Inc
Publication of MX2021011647A publication Critical patent/MX2021011647A/es

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    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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  • Pyridine Compounds (AREA)

Abstract

Se proporcionan métodos para modular MRGPR X4 en general, o para tratar una afección dependiente de MRGPR X4 más específicamente, poniendo en contacto el MRGPR X4 o administrando a un sujeto que lo necesite, respectivamente, una cantidad efectiva de un compuesto que tiene la estructura de Fórmula (I): (I) o un isómero, racemato, hidrato, solvato, isótopo o sal farmacéuticamente aceptable del mismo, en donde n, x, A, Q1, Q2, Z, R, R1, R2, R3, R4 y R5 son como se define en este documento. También se proporcionan composiciones farmacéuticas que contienen los compuestos, así como los propios compuestos.
MX2021011647A 2019-03-28 2020-03-26 Moduladores del receptor x4 de proteina g relacionado con mas y productos y metodos relacionados. MX2021011647A (es)

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