MX2021012903A - Moduladores de la via de respuesta integrada al estres. - Google Patents
Moduladores de la via de respuesta integrada al estres.Info
- Publication number
- MX2021012903A MX2021012903A MX2021012903A MX2021012903A MX2021012903A MX 2021012903 A MX2021012903 A MX 2021012903A MX 2021012903 A MX2021012903 A MX 2021012903A MX 2021012903 A MX2021012903 A MX 2021012903A MX 2021012903 A MX2021012903 A MX 2021012903A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- stress response
- modulators
- integrated stress
- response pathway
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a los compuestos de la fórmula (I) (ver Fórmula) o sales farmacéuticamente aceptables, solvatos, hidratos, tautómeros o estereoisómeros de los mismos, en donde R1, R2, R2a, R3, Ra2, Ra4, Ra5, Ra6, Ra7, X1, X1a, A1 y A2 tienen el significado que se indica en la descripción y en las reivindicaciones. La invención se refiere además a composiciones farmacéuticas que comprenden dichos compuestos, su uso como medicamento y a un método para tratar y prevenir una o más enfermedades o trastornos asociados con la respuesta integrada al estrés.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19170504 | 2019-04-23 | ||
EP19216875 | 2019-12-17 | ||
PCT/EP2020/061150 WO2020216766A1 (en) | 2019-04-23 | 2020-04-22 | Modulators of the integrated stress response pathway |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021012903A true MX2021012903A (es) | 2022-01-18 |
Family
ID=70289816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021012903A MX2021012903A (es) | 2019-04-23 | 2020-04-22 | Moduladores de la via de respuesta integrada al estres. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20220227747A1 (es) |
EP (1) | EP3959198A1 (es) |
JP (1) | JP2022530049A (es) |
KR (1) | KR20220004105A (es) |
CN (1) | CN113993850B (es) |
AU (1) | AU2020261234A1 (es) |
BR (1) | BR112021020402A2 (es) |
CA (1) | CA3137213A1 (es) |
CL (1) | CL2021002772A1 (es) |
CO (1) | CO2021014292A2 (es) |
IL (1) | IL287379A (es) |
MX (1) | MX2021012903A (es) |
PE (1) | PE20220961A1 (es) |
SG (1) | SG11202111119PA (es) |
WO (1) | WO2020216766A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20200110650A (ko) | 2017-12-13 | 2020-09-24 | 프락시스 바이오테크 엘엘씨 | 통합된 스트레스 반응 경로의 억제제 |
EP3801522A4 (en) | 2018-06-05 | 2022-06-01 | Praxis Biotech LLC | INTEGRATED STRESS RESPONSE PATHWAY INHIBITORS |
JP2022536663A (ja) | 2019-06-12 | 2022-08-18 | プラクシス バイオテック エルエルシー | 統合的ストレス応答経路のモジュレーター |
WO2021165927A1 (en) * | 2020-02-21 | 2021-08-26 | Wockhardt Bio Ag | 2-cyanopyrroldines, -piperidines or -dazepines as hyperglycemic agents |
US20230129907A1 (en) | 2020-03-11 | 2023-04-27 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
MX2023004626A (es) | 2020-10-22 | 2023-05-23 | Evotec Int Gmbh | Moduladores de la via de respuesta integrada al estres. |
MX2023004623A (es) | 2020-10-22 | 2023-05-12 | Evotec Int Gmbh | Moduladores de la via integrada de respuesta al estres. |
KR20230110510A (ko) | 2020-10-22 | 2023-07-24 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절제 |
WO2022212902A1 (en) * | 2021-04-02 | 2022-10-06 | Altos Labs, Inc. | Modulators of integrated stress response pathway |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6806562B2 (ja) | 2013-03-15 | 2021-01-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | eIF2α経路の調節因子 |
JP6291601B2 (ja) * | 2014-07-04 | 2018-03-14 | ルピン・リミテッド | Pi3k阻害剤としてのキノリジノン誘導体 |
TW201722957A (zh) * | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產(第二)有限公司 | 化學化合物 |
WO2017046739A1 (en) * | 2015-09-15 | 2017-03-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Imidazolidinone derivatives as inhibitors of perk |
TW201808914A (zh) | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
TW201808888A (zh) | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
TW201808903A (zh) | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
TWI763668B (zh) | 2016-05-05 | 2022-05-11 | 美商嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
AU2017279027A1 (en) * | 2016-06-08 | 2018-12-20 | Glaxosmithkline Intellectual Property Development Limited | Chemical Compounds |
US20190298705A1 (en) * | 2016-06-08 | 2019-10-03 | Glaxosmithkline Intellectual Property Development Limited | Chemical Compounds |
WO2018225093A1 (en) | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
BR112020000086A2 (pt) | 2017-07-03 | 2020-07-07 | Glaxosmithkline Intellectual Property Development Limited | derivados de 2-(4-clorofenóxi)-n-((1-(2-(4-clorofenóxi) etinazetidin-3-il) metil) acetamida e compostos relacionados como inibidores de atf4 para tratamento de câncer e outras doenças |
JP2020525513A (ja) | 2017-07-03 | 2020-08-27 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 癌および他の疾患を治療するためのatf4阻害剤としてのn−(3−(2−(4−クロロフェノキシ)アセトアミドビシクロ[1.1.1]ペンタン−1−イル)−2−シクロブタン−1−カルボキサミド誘導体および関連化合物 |
SG11202000532SA (en) | 2017-08-09 | 2020-02-27 | Denali Therapeutics Inc | Compounds, compositions and methods |
JP7382308B2 (ja) * | 2017-09-01 | 2023-11-16 | デナリ セラピューティクス インコーポレイテッド | 化合物、組成物、及び、方法 |
BR112020008833A2 (pt) | 2017-11-02 | 2020-10-20 | Calico Life Sciences Llc | moduladores da via de estresse integrada |
UY37958A (es) | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
UY37956A (es) | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
MX2020004557A (es) | 2017-11-02 | 2020-10-05 | Calico Life Sciences Llc | Moduladores de la vía de estrés integrada. |
CA3080808A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
UY37957A (es) | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
EP3704089B1 (en) | 2017-11-02 | 2023-07-19 | Calico Life Sciences LLC | Modulators of the integrated stress pathway |
WO2019090082A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
WO2019090090A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
KR20200110650A (ko) | 2017-12-13 | 2020-09-24 | 프락시스 바이오테크 엘엘씨 | 통합된 스트레스 반응 경로의 억제제 |
WO2019183589A1 (en) * | 2018-03-23 | 2019-09-26 | Denali Therapeutics Inc. | Modulators of eukaryotic initiation factor 2 |
WO2019193541A1 (en) | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
WO2019193540A1 (en) | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Heteroaryl derivatives of formula (i) as atf4 inhibitors |
-
2020
- 2020-04-22 BR BR112021020402A patent/BR112021020402A2/pt unknown
- 2020-04-22 MX MX2021012903A patent/MX2021012903A/es unknown
- 2020-04-22 PE PE2021001762A patent/PE20220961A1/es unknown
- 2020-04-22 EP EP20719452.3A patent/EP3959198A1/en active Pending
- 2020-04-22 US US17/605,037 patent/US20220227747A1/en active Pending
- 2020-04-22 AU AU2020261234A patent/AU2020261234A1/en active Pending
- 2020-04-22 SG SG11202111119PA patent/SG11202111119PA/en unknown
- 2020-04-22 JP JP2021562988A patent/JP2022530049A/ja active Pending
- 2020-04-22 WO PCT/EP2020/061150 patent/WO2020216766A1/en unknown
- 2020-04-22 KR KR1020217037824A patent/KR20220004105A/ko unknown
- 2020-04-22 CA CA3137213A patent/CA3137213A1/en active Pending
- 2020-04-22 CN CN202080045788.1A patent/CN113993850B/zh active Active
-
2021
- 2021-10-19 IL IL287379A patent/IL287379A/en unknown
- 2021-10-22 CL CL2021002772A patent/CL2021002772A1/es unknown
- 2021-10-26 CO CONC2021/0014292A patent/CO2021014292A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN113993850B (zh) | 2024-03-29 |
US20220227747A1 (en) | 2022-07-21 |
CO2021014292A2 (es) | 2022-04-29 |
IL287379A (en) | 2021-12-01 |
EP3959198A1 (en) | 2022-03-02 |
CN113993850A (zh) | 2022-01-28 |
BR112021020402A2 (pt) | 2021-12-07 |
JP2022530049A (ja) | 2022-06-27 |
WO2020216766A1 (en) | 2020-10-29 |
PE20220961A1 (es) | 2022-06-10 |
AU2020261234A1 (en) | 2021-11-11 |
CA3137213A1 (en) | 2020-10-29 |
CL2021002772A1 (es) | 2022-07-29 |
SG11202111119PA (en) | 2021-11-29 |
KR20220004105A (ko) | 2022-01-11 |
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