MX2021010834A - Compuesto y metodo para la prevencion de transmision del virus de influenza. - Google Patents

Compuesto y metodo para la prevencion de transmision del virus de influenza.

Info

Publication number
MX2021010834A
MX2021010834A MX2021010834A MX2021010834A MX2021010834A MX 2021010834 A MX2021010834 A MX 2021010834A MX 2021010834 A MX2021010834 A MX 2021010834A MX 2021010834 A MX2021010834 A MX 2021010834A MX 2021010834 A MX2021010834 A MX 2021010834A
Authority
MX
Mexico
Prior art keywords
compound
influenza
patient
influenza virus
index
Prior art date
Application number
MX2021010834A
Other languages
English (en)
Inventor
Steffen Wildum
Takao Shishido
Takeshi Noshi
Yoshinori Ando
Takahiro Noda
Ryu Yoshida
Kaoru Baba
Aeron C Hurt
Leo Yi Yang Lee
Klaus Kuhlbusch
Barry Clinch
Michael J Nebesky
Annabelle Lemenuel-Diot
Wendy S Barclay
Jean-Eric Charoin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2021010834A publication Critical patent/MX2021010834A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se relaciona con un método para evitar la transmisión de influenza, en donde el método comprende administrar una cantidad eficaz de un compuesto a un paciente que tiene infección por virus de influenza, en la presente denominado como "paciente índice", en donde el compuesto tiene una de las fórmulas (I) y (II), o su sal farmacéuticamente aceptable. El compuesto que va a ser usado en la presente invención reduce la infectividad del virus de la influenza del paciente índice, y por lo tanto reduce el riesgo de que el paciente índice active una epidemia de influenza o una pandemia de influenza en comparación con un paciente control. Por lo tanto, un aspecto de la presente invención se relaciona con un método para evitar una epidemia de influenza o una pandemia de influenza, en donde el método comprende administrar una cantidad eficaz de un compuesto a pacientes que presentan infección por virus de influenza (pacientes índice), en donde el compuesto se administra a por lo menos 10% de todas las personas infectadas con influenza de una ciudad o la población de un país, y en donde el compuesto tiene una de las fórmulas (I) y (II) o es una sal farmacéuticamente aceptable del mismo.
MX2021010834A 2019-03-29 2020-03-26 Compuesto y metodo para la prevencion de transmision del virus de influenza. MX2021010834A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19166228.7A EP3714889A1 (en) 2019-03-29 2019-03-29 Baloxavir for the prevention of transmission of influenza virus
PCT/EP2020/058573 WO2020201019A1 (en) 2019-03-29 2020-03-26 Compound and method for the prevention of transmission of influenza virus

Publications (1)

Publication Number Publication Date
MX2021010834A true MX2021010834A (es) 2021-10-14

Family

ID=66041247

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021010834A MX2021010834A (es) 2019-03-29 2020-03-26 Compuesto y metodo para la prevencion de transmision del virus de influenza.

Country Status (12)

Country Link
US (2) US11389457B2 (es)
EP (2) EP3714889A1 (es)
JP (1) JP2022526366A (es)
KR (1) KR20210146992A (es)
CN (1) CN113784719A (es)
AU (1) AU2020254906A1 (es)
BR (1) BR112021014421A2 (es)
CA (1) CA3129668A1 (es)
IL (1) IL284990A (es)
MX (1) MX2021010834A (es)
TW (1) TW202102227A (es)
WO (1) WO2020201019A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112542250A (zh) * 2020-11-04 2021-03-23 温州大学 基于优化seird模型的全球新冠病毒传播预测方法
CN114601803B (zh) * 2020-12-07 2023-08-01 谢斌 一种巴洛沙韦酯干混悬剂及其制备方法和应用
KR20230062080A (ko) 2021-10-29 2023-05-09 코웨이 주식회사 냉수 탱크

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166435B2 (en) * 2001-08-06 2007-01-23 The Quigley Corporation Compositions and methods for reducing the transmissivity of illnesses
WO2010147068A1 (ja) 2009-06-15 2010-12-23 塩野義製薬株式会社 置換された多環性カルバモイルピリドン誘導体
DK2620436T3 (en) 2010-09-24 2018-07-30 Shionogi & Co Substituted polycyclic carbamoylpyridone derivative prodrug
DK3428170T3 (da) 2015-04-28 2021-03-01 Shionogi & Co Anti-influenza polycyklisk pyridonderivat og prodrug deraf
JP6323860B2 (ja) 2015-12-15 2018-05-16 塩野義製薬株式会社 キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬
NZ750052A (en) 2016-08-10 2024-08-30 Shionogi & Co Ltd Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof
TWI795462B (zh) * 2017-11-17 2023-03-11 日商鹽野義製藥股份有限公司 光安定性及溶出性優異的醫藥製劑
WO2020058745A1 (en) 2018-09-18 2020-03-26 Shionogi & Co., Ltd. Treating influenza using substituted polycyclic pyridone derivatives and prodrugs thereof
AU2019433734A1 (en) * 2019-03-12 2021-09-30 Shionogi & Co., Ltd. Treating influenza using substituted polycyclic pyridone derivatives and prodrugs thereof in a subject having influenza and a complication risk factor
US20220008429A2 (en) 2019-03-22 2022-01-13 Shionogi & Co., Ltd. Treating influenza using substituted polycyclic pyridone derivatives and prodrugs thereof in a subject having influenza and a severe influenza condition
US20210069204A1 (en) 2019-08-13 2021-03-11 F. Hoffmann-La Roche Ag Dosage of baloxavir marboxil for pediatric patients
KR20220045199A (ko) 2019-08-13 2022-04-12 에프. 호프만-라 로슈 아게 소아 환자를 위한 발록사비르 마르복실의 개선된 투여량

Also Published As

Publication number Publication date
US11911394B2 (en) 2024-02-27
KR20210146992A (ko) 2021-12-06
IL284990A (en) 2021-09-30
CN113784719A (zh) 2021-12-10
JP2022526366A (ja) 2022-05-24
BR112021014421A2 (pt) 2021-10-05
EP3714889A1 (en) 2020-09-30
AU2020254906A1 (en) 2021-08-19
CA3129668A1 (en) 2020-10-08
WO2020201019A1 (en) 2020-10-08
EP3946356A1 (en) 2022-02-09
US11389457B2 (en) 2022-07-19
US20220331331A1 (en) 2022-10-20
US20200330473A1 (en) 2020-10-22
TW202102227A (zh) 2021-01-16

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