MX2021009352A - Compuestos de fijacion al receptor de il -2. - Google Patents

Compuestos de fijacion al receptor de il -2.

Info

Publication number
MX2021009352A
MX2021009352A MX2021009352A MX2021009352A MX2021009352A MX 2021009352 A MX2021009352 A MX 2021009352A MX 2021009352 A MX2021009352 A MX 2021009352A MX 2021009352 A MX2021009352 A MX 2021009352A MX 2021009352 A MX2021009352 A MX 2021009352A
Authority
MX
Mexico
Prior art keywords
ligands
receptor binding
binding compounds
compounds
2ryc
Prior art date
Application number
MX2021009352A
Other languages
English (en)
Inventor
William J Dower
Michael C Needels
Ronald W Barrett
Alice V Bakker
Steven E Cwirla
Original Assignee
Medikine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medikine Inc filed Critical Medikine Inc
Publication of MX2021009352A publication Critical patent/MX2021009352A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se divulgan ligandos de IL-2Rß y ligandos de IL-2R?c y compuestos que comprenden los ligandos. Los ligandos y los compuestos tales como heterodímeros y proteínas de fusión que comprenden los ligandos de IL-2Rß y/o los ligandos de IL-2R?c pueden ser agonistas del receptor de IL-2.
MX2021009352A 2018-08-06 2021-02-05 Compuestos de fijacion al receptor de il -2. MX2021009352A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862715097P 2018-08-06 2018-08-06
US201862785754P 2018-12-28 2018-12-28

Publications (1)

Publication Number Publication Date
MX2021009352A true MX2021009352A (es) 2021-09-10

Family

ID=67777396

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2021001493A MX2021001493A (es) 2018-08-06 2019-08-05 Compuestos de fijación al receptor de il-2.
MX2021009352A MX2021009352A (es) 2018-08-06 2021-02-05 Compuestos de fijacion al receptor de il -2.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2021001493A MX2021001493A (es) 2018-08-06 2019-08-05 Compuestos de fijación al receptor de il-2.

Country Status (13)

Country Link
US (6) US10703776B2 (es)
EP (2) EP4023667A1 (es)
JP (1) JP7289158B2 (es)
KR (2) KR20210055694A (es)
CN (2) CN112585160A (es)
AU (2) AU2019317353B2 (es)
BR (2) BR112021002250A2 (es)
CA (2) CA3172359A1 (es)
IL (1) IL280670A (es)
MX (2) MX2021001493A (es)
RU (1) RU2021105821A (es)
TW (3) TWI822827B (es)
WO (1) WO2020033312A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10703776B2 (en) 2018-08-06 2020-07-07 Medikine, Inc. IL-2RBeta binding compounds
US11248025B2 (en) 2019-06-03 2022-02-15 Medikine, Inc. IL-2alpha receptor subunit binding compounds
EP4055037A1 (en) * 2019-11-05 2022-09-14 Medikine, Inc. Il-2r beta gamma c binding compounds
KR20220110209A (ko) 2019-11-05 2022-08-05 메디카인 인코포레이티드 이중 il-2r 및 il-7r 결합 화합물
EP4100046A4 (en) 2020-02-03 2024-03-06 Medikine, Inc. IL-7R-ALPHA BINDING COMPOUNDS
TW202342505A (zh) 2020-02-03 2023-11-01 美商麥地金公司 IL-7Rαγc結合化合物
IL302575A (en) * 2020-11-04 2023-07-01 Medikine Inc IL-2R beta gamma c binding compounds and uses thereof
CN112451662A (zh) * 2020-12-22 2021-03-09 中山大学孙逸仙纪念医院 一种gli蛋白抑制剂及其应用
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
US11999771B2 (en) 2022-04-07 2024-06-04 Medikine, Inc. IL-7Rαγc ligand immunoglobulin fusion proteins
US20230381277A1 (en) * 2022-04-08 2023-11-30 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and immunosuppressants to enhance immune tolerance
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
WO2024054870A1 (en) 2022-09-06 2024-03-14 Medikine, Inc. Use of il-7r-alpha-gamma agonist peptides in cell manufacturing
WO2024054874A1 (en) 2022-09-06 2024-03-14 Medikine, Inc. Use of il-2r-beta-gamma agonist peptides in cell manufacturing
CN115532290B (zh) * 2022-10-13 2024-04-30 浙江昌海制药有限公司 一种特定晶面选择性氢化催化剂及其制备方法和应用

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US5635597A (en) * 1994-05-27 1997-06-03 Affymax Technologies, N.V. Peptides that bind IL-2 receptors
EP2354791A1 (en) 2001-12-04 2011-08-10 Merck Patent GmbH Immunocytokines with modulated selectivity
RU2369616C2 (ru) 2003-12-30 2009-10-10 Мерк Патент Гмбх Слитые белки il-7
CA2591510A1 (en) 2004-12-22 2006-06-29 Novartis Vaccines And Diagnostics, Inc. Group b streptococcus
WO2010099084A2 (en) 2009-02-27 2010-09-02 Monsanto Technology Llc Isolated novel nucleic acid and protein molecules from corn and methods of using those molecules
HUE054318T2 (hu) 2010-11-12 2021-08-30 Nektar Therapeutics IL-2 molekularész konjugátumai és polimer
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SI3180020T1 (sl) 2014-08-11 2019-04-30 Delinia, Inc. Modificirane variante IL-2, ki selektivno aktivirajo regulatorne celice T, za zdravljenje avtoimunih bolezni
KR20180037239A (ko) 2015-08-06 2018-04-11 에이전시 포 사이언스, 테크놀로지 앤드 리서치 Il2r 베타/공통 감마 체인 항체
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US10703776B2 (en) 2018-08-06 2020-07-07 Medikine, Inc. IL-2RBeta binding compounds
EP4055037A1 (en) 2019-11-05 2022-09-14 Medikine, Inc. Il-2r beta gamma c binding compounds
KR20220110209A (ko) * 2019-11-05 2022-08-05 메디카인 인코포레이티드 이중 il-2r 및 il-7r 결합 화합물
TW202342505A (zh) 2020-02-03 2023-11-01 美商麥地金公司 IL-7Rαγc結合化合物
EP4100046A4 (en) 2020-02-03 2024-03-06 Medikine, Inc. IL-7R-ALPHA BINDING COMPOUNDS

Also Published As

Publication number Publication date
CA3108865A1 (en) 2020-02-13
AU2019317353B2 (en) 2022-02-17
AU2022202577A1 (en) 2022-05-12
RU2021105821A (ru) 2021-05-27
CN113651880A (zh) 2021-11-16
CA3172359A1 (en) 2020-02-13
US20220275026A1 (en) 2022-09-01
BR122021012517A2 (pt) 2021-08-10
JP2021535196A (ja) 2021-12-16
US11548914B2 (en) 2023-01-10
AU2022202577B2 (en) 2024-03-07
IL280670A (en) 2021-03-25
US11358986B2 (en) 2022-06-14
US10703776B2 (en) 2020-07-07
TW202026306A (zh) 2020-07-16
TWI743528B (zh) 2021-10-21
KR20210055070A (ko) 2021-05-14
US20200291067A1 (en) 2020-09-17
AU2019317353A1 (en) 2021-03-11
KR20210055694A (ko) 2021-05-17
US20200040036A1 (en) 2020-02-06
JP7289158B2 (ja) 2023-06-09
TW202033543A (zh) 2020-09-16
US10689417B2 (en) 2020-06-23
TW202200604A (zh) 2022-01-01
US20230192767A1 (en) 2023-06-22
US20200291066A1 (en) 2020-09-17
EP4023667A1 (en) 2022-07-06
EP3833679A1 (en) 2021-06-16
CN112585160A (zh) 2021-03-30
WO2020033312A1 (en) 2020-02-13
BR112021002250A2 (pt) 2021-07-20
MX2021001493A (es) 2021-07-15
US20200040034A1 (en) 2020-02-06
TWI822827B (zh) 2023-11-21

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