MX2021002333A - Metodo basado en proteogenomica para identificar antigenos especificos de tumores. - Google Patents

Metodo basado en proteogenomica para identificar antigenos especificos de tumores.

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Publication number
MX2021002333A
MX2021002333A MX2021002333A MX2021002333A MX2021002333A MX 2021002333 A MX2021002333 A MX 2021002333A MX 2021002333 A MX2021002333 A MX 2021002333A MX 2021002333 A MX2021002333 A MX 2021002333A MX 2021002333 A MX2021002333 A MX 2021002333A
Authority
MX
Mexico
Prior art keywords
cells
tumor
sup
specific antigens
normal
Prior art date
Application number
MX2021002333A
Other languages
English (en)
Spanish (es)
Inventor
Céline Laumont
Pierre Thibault
Sébastien Lemieux
Claude Perreault
Original Assignee
Univ Montreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Montreal filed Critical Univ Montreal
Publication of MX2021002333A publication Critical patent/MX2021002333A/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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MX2021002333A 2018-08-30 2019-08-28 Metodo basado en proteogenomica para identificar antigenos especificos de tumores. MX2021002333A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862724760P 2018-08-30 2018-08-30
PCT/CA2019/051186 WO2020041876A1 (en) 2018-08-30 2019-08-28 Proteogenomic-based method for identifying tumor-specific antigens

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MX2021002333A true MX2021002333A (es) 2021-04-28

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MX2021002333A MX2021002333A (es) 2018-08-30 2019-08-28 Metodo basado en proteogenomica para identificar antigenos especificos de tumores.

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US (2) US11702450B2 (https=)
EP (1) EP3844172A4 (https=)
JP (3) JP7468911B2 (https=)
KR (1) KR102944795B1 (https=)
CN (2) CN112639136B (https=)
AU (1) AU2019330487B2 (https=)
BR (1) BR112021002394A2 (https=)
CA (1) CA3109716A1 (https=)
IL (1) IL280651B2 (https=)
MX (1) MX2021002333A (https=)
SG (1) SG11202100528YA (https=)
WO (1) WO2020041876A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111477274B (zh) * 2020-04-02 2020-11-24 上海之江生物科技股份有限公司 微生物目标片段中特异性区域的识别方法、装置及应用
US20230158132A1 (en) * 2020-04-14 2023-05-25 Universite De Montreal Novel tumor-specific antigens for acute lymphoblastic leukemia (all) and uses thereof
AU2021256477A1 (en) * 2020-04-14 2022-11-10 Université de Montréal Novel tumor-specific antigens for acute myeloid leukemia (AML) and uses thereof
JP2023540904A (ja) 2020-08-25 2023-09-27 シアー， インコーポレイテッド タンパク質および核酸をアッセイするための組成物および方法
CN112331267A (zh) * 2020-09-25 2021-02-05 浙江大学 一种基于质谱的不动杆菌数据库的构建方法及不动杆菌数据库
US20240382590A1 (en) * 2021-07-16 2024-11-21 Université de Montréal Novel tumor-specific antigens for cancer stem cells and uses thereof
CN113593649B (zh) * 2021-08-02 2022-09-09 中国人民解放军陆军军医大学第一附属医院 一种利用hla-i候选肽库鉴定组织中提取的天然抗原肽的方法
KR102694155B1 (ko) * 2021-09-14 2024-08-13 한국과학기술원 막 단백질 정보를 이용한 치료 타깃 유전자 발굴 방법 및 분석장치
MX2024003142A (es) * 2021-09-17 2024-04-10 Univ Montreal Antigenos especificos de tumores novedosos para el cancer colorrectal y usos de estos.
US20260048105A1 (en) * 2022-08-08 2026-02-19 Université de Montréal Novel antigens for cancer and uses thereof
AU2024287610A1 (en) * 2023-07-12 2026-01-29 Anda Biology Medicine Development (Shenzhen) Co., Ltd Novel markers for tumor neoantigen vaccines
JP7599641B1 (ja) 2023-08-22 2024-12-16 ｃＢｉｏｉｎｆｏｒｍａｔｉｃｓ株式会社 ネオアンチゲン予測装置、ネオアンチゲン予測方法、およびプログラム

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020519A1 (en) 1999-01-15 2000-07-19 Introgene B.V. Minor histocompatibility antigens and their use in the diagnosis and treatment of tumors
JP2006129832A (ja) * 2004-11-09 2006-05-25 Aichi Prefecture ＣａｔｈｅｐｓｉｎＨタンパク質由来のＣＤ８＋細胞傷害性Ｔリンパ球ｍＨＡエピトープペプチド及びその用途
EP1748067A1 (en) * 2005-07-29 2007-01-31 Institut Pasteur Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes
WO2007119515A1 (ja) * 2006-03-28 2007-10-25 Dainippon Sumitomo Pharma Co., Ltd. 新規腫瘍抗原ペプチド
CN102268089A (zh) 2011-07-05 2011-12-07 上海交通大学 Agr2阻断抗体及其用途
CA2988388C (en) * 2015-04-23 2022-11-22 Nantomics, Llc Cancer neoepitopes
GB201511191D0 (en) * 2015-06-25 2015-08-12 Immatics Biotechnologies Gmbh T-cell epitopes for the immunotherapy of myeloma
RU2729116C2 (ru) * 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов
CN109416925A (zh) * 2016-05-05 2019-03-01 南托米克斯有限责任公司 检查点失效和使检查点失效的方法
US10350280B2 (en) * 2016-08-31 2019-07-16 Medgenome Inc. Methods to analyze genetic alterations in cancer to identify therapeutic peptide vaccines and kits therefore
PE20191345A1 (es) * 2016-11-23 2019-09-30 Gritstone Oncology Inc Administracion viral de neoantigenos
JP7197481B2 (ja) * 2016-11-30 2022-12-27 アドバクシス， インコーポレイテッド 反復性がん突然変異を標的とする免疫原性組成物およびその使用の方法
CN118666956A (zh) 2019-06-25 2024-09-20 蒙特利尔大学 肿瘤抗原肽、肽组合、核酸、负载体、疫苗及其用途

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