MX2021002333A - Metodo basado en proteogenomica para identificar antigenos especificos de tumores. - Google Patents

Metodo basado en proteogenomica para identificar antigenos especificos de tumores.

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Publication number
MX2021002333A
MX2021002333A MX2021002333A MX2021002333A MX2021002333A MX 2021002333 A MX2021002333 A MX 2021002333A MX 2021002333 A MX2021002333 A MX 2021002333A MX 2021002333 A MX2021002333 A MX 2021002333A MX 2021002333 A MX2021002333 A MX 2021002333A
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MX
Mexico
Prior art keywords
tumor
cells
proteogenomic
sup
specific antigens
Prior art date
Application number
MX2021002333A
Other languages
English (en)
Inventor
Céline Laumont
Pierre Thibault
Sébastien Lemieux
Claude Perreault
Original Assignee
Univ Montreal
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Publication date
Application filed by Univ Montreal filed Critical Univ Montreal
Publication of MX2021002333A publication Critical patent/MX2021002333A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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Abstract

Se sabe que las células T, en particular las células T CD8, son actores esenciales en la erradicación de tumores, ya que la presencia de linfocitos infiltrantes de tumores (TIL) en varios cánceres se correlaciona positivamente con un buen pronóstico. Para eliminar las células tumorales, las células T CD8 reconocen los antígenos tumorales, que son péptidos asociados al MHC I presente en la superficie de las células tumorales, con una expresión muy baja o nula en las células normales. En la presente descripción se describe un enfoque proteogenómico mediante el uso de datos de secuenciación de ARN de muestras mTEChi cancerosas y normales equivalentes con el fin de identificar antígenos específicos de tumores no tolerogénicos derivados de (i) regiones codificantes y no codificantes del genoma, (ii) mutaciones de base única no sinónimas o inserciones/deleciones cortas y reordenamientos más complejos, así como también (iii) retroelementos endógenos, que funcionan independientemente de la carga mutacional o la complejidad de la muestra.
MX2021002333A 2018-08-30 2019-08-28 Metodo basado en proteogenomica para identificar antigenos especificos de tumores. MX2021002333A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862724760P 2018-08-30 2018-08-30
PCT/CA2019/051186 WO2020041876A1 (en) 2018-08-30 2019-08-28 Proteogenomic-based method for identifying tumor-specific antigens

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MX2021002333A true MX2021002333A (es) 2021-04-28

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EP (1) EP3844172A4 (es)
JP (2) JP7468911B2 (es)
KR (1) KR20210049150A (es)
CN (2) CN112639136B (es)
AU (1) AU2019330487A1 (es)
BR (1) BR112021002394A2 (es)
CA (1) CA3109716A1 (es)
IL (1) IL280651B2 (es)
MX (1) MX2021002333A (es)
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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111477274B (zh) * 2020-04-02 2020-11-24 上海之江生物科技股份有限公司 微生物目标片段中特异性区域的识别方法、装置及应用
CA3173664A1 (en) * 2020-04-14 2021-10-21 Claude Perreault Novel tumor-specific antigens for acute lymphoblastic leukemia (all) and uses thereof
CN112331267A (zh) * 2020-09-25 2021-02-05 浙江大学 一种基于质谱的不动杆菌数据库的构建方法及不动杆菌数据库
WO2023023840A1 (en) * 2021-07-16 2023-03-02 Université de Montréal Novel tumor-specific antigens for cancer stem cells and uses thereof
CN113593649B (zh) * 2021-08-02 2022-09-09 中国人民解放军陆军军医大学第一附属医院 一种利用hla-i候选肽库鉴定组织中提取的天然抗原肽的方法
KR102694155B1 (ko) * 2021-09-14 2024-08-13 한국과학기술원 막 단백질 정보를 이용한 치료 타깃 유전자 발굴 방법 및 분석장치
JP2024535853A (ja) * 2021-09-17 2024-10-02 ウニヴェルシテ ド モントリオール 結腸直腸がんに対する新規の腫瘍特異的抗原及びそれらの使用
WO2024031181A1 (en) * 2022-08-08 2024-02-15 Université de Montréal Novel antigens for cancer and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020519A1 (en) 1999-01-15 2000-07-19 Introgene B.V. Minor histocompatibility antigens and their use in the diagnosis and treatment of tumors
JP2006129832A (ja) * 2004-11-09 2006-05-25 Aichi Prefecture ＣａｔｈｅｐｓｉｎＨタンパク質由来のＣＤ８＋細胞傷害性Ｔリンパ球ｍＨＡエピトープペプチド及びその用途
CN102268089A (zh) * 2011-07-05 2011-12-07 上海交通大学 Agr2阻断抗体及其用途
GB201511191D0 (en) * 2015-06-25 2015-08-12 Immatics Biotechnologies Gmbh T-cell epitopes for the immunotherapy of myeloma
WO2017106638A1 (en) * 2015-12-16 2017-06-22 Gritstone Oncology, Inc. Neoantigen identification, manufacture, and use
AU2017261353A1 (en) * 2016-05-05 2018-11-08 Nantomics, Llc Checkpoint failure and methods therefor
US10350280B2 (en) * 2016-08-31 2019-07-16 Medgenome Inc. Methods to analyze genetic alterations in cancer to identify therapeutic peptide vaccines and kits therefore
EP3548623A4 (en) * 2016-11-30 2020-11-25 Advaxis, Inc. IMMUNOGENIC COMPOSITIONS TARGETING RECURRENT CANCER MUTATIONS AND THEIR USE PROCEDURES
BR112021025943A2 (pt) 2019-06-25 2022-02-08 Univ Montreal Antígenos específicos de tumor inovadores para câncer de ovário e usos dos mesmos

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AU2019330487A1 (en) 2021-02-04
IL280651B1 (en) 2024-01-01
WO2020041876A1 (en) 2020-03-05
KR20210049150A (ko) 2021-05-04
CA3109716A1 (en) 2020-03-05
SG11202100528YA (en) 2021-02-25
CN118755835A (zh) 2024-10-11
EP3844172A1 (en) 2021-07-07
US11702450B2 (en) 2023-07-18
CN112639136A (zh) 2021-04-09
JP2021534830A (ja) 2021-12-16
CN112639136B (zh) 2024-08-02
IL280651A (en) 2021-03-25
EP3844172A4 (en) 2022-08-10
US20230242583A1 (en) 2023-08-03
JP2024112795A (ja) 2024-08-21
US20210253638A1 (en) 2021-08-19
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JP7468911B2 (ja) 2024-04-16
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